Botryorhodine J, a new anti-MRSA depsidone isolated from endophytic fungus Pas11.

A new depsidone derivative botryorhodine J (), along with six known compounds (-) were obtained from solid rice cultures of Pas11 that was isolated from leaves of . The structure of the new compound was elucidated on the basis of combination of NMR spectroscopic data and high resolution mass spectrometry (HRMS). All the isolated compounds were evaluated for their antibacterial activities against a panel of Gram-positive bacterial strains (methicillin-resistant [MRSA], and ).

[Research progress on antitumor activity of quercetin derivatives].

Quercetin is a kind of typical flavonoid, mainly found in various vegetables, fruits and Chinese herbs that are consumed daily, with the functions of anti-oxidation, anti-tumor, prevention and treatment of cardiovascular and cerebrovascular diseases. Quercetin is a natural compound with defined anti-tumor activity. Due to its low bioavailability and poor water solubility, quercetin has limitations in clinical application.

Synthesis and biological evaluation of vanadium complexes as novel anti-tumor agents.

A class of vanadium complexes were prepared and investigated for their antiproliferative effects by MTT assay. The structure-activity relationship was extensively studied through the ligand variation. The results showed that the synthetic vanadium complexes demonstrated moderate to good antiproliferative activities against the four cancer cell lines including MGC803, EC109, MCF7 and HepG2, respectively.

Discovery of vanadium complexes bearing tridentate schiff base ligands as novel LSD1 inhibitors.

Lysine specific demethylase (LSD1) plays a pivotal role in epigenetic modulation of gene expression. Abberrant expression of LSD1 was associated with the progress and oncogenesis of multiple human cancers. Herein, we report the preliminary anti-LSD1 evaluation of the synthetic vanadium (V) complexes.

[ONN]-type amine pyridine(s) phenolate-based oxovanadium(V) catalysts for ethylene homo- and copolymerization.

A series of oxovanadium(V) complexes containing amine pyridine(s) phenolate ligands [ONN] (2a-f) have been synthesized in high yields (68-83%) by reacting VO(O(n)Pr)3 with 1.0 equiv. of the ligands in CH2Cl2.