Potential of Klotho as a Biomarker for Overwork: A Study of Frontline Medical Workers.

Objective: This study evaluates the utility of serum s-αKlotho levels as a quantifiable biomarker for overwork.

Methods: Frontline medical workers aged 20-55 from Yiling People's Hospital of Yichang were recruited. Criteria included non-smokers, non-heavy drinkers, no chronic medication use, and no acute illnesses recently.

Bilateral sensorineural hearing loss induced by regorafenib.

What Is Known And Objective: Regorafenib is a novel multi-targeted tyrosine kinase inhibitor approved for use in refractory metastatic colorectal cancer, advanced gastrointestinal stromal tumours and hepatocellular carcinoma. We report a case of bilateral sensorineural hearing loss caused by regorafenib.

Case Summary: A 48-year-old woman was diagnosed with colon cancer that had metastasized to the liver, ureter and left ovary.

Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy.

Diabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients. Effective therapies to prevent the development of this disease and to improve advanced kidney injury are required. Berberine (BBR) has preventive effects on diabetes and its complications.

Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathy.

Diabetic nephropathy (DN) is a progressive kidney disease that is caused by injury to glomerulus and glomerular mesangial cells (MCs) proliferation play a critical role in the pathogenesis of DN. The current studies were undertaken to investigate the protective effects and the possible molecular mechanism of berberine on streptozotocin (STZ)-induced DN rats. Male Wistar rats were randomly assigned to normal control and DN groups of comparable age.

Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats.

Berberine (BBR), an effective compound of Chinese traditional herbal medicine, has preventive effects on diabetes and its complications. In this study, we investigated the therapeutic effects and underlying molecular mechanisms of BBR in rats with high-fat diet and streptozotocin (STZ)-induced diabetic nephropathy model. BBR (50, 100, 200 mg/kg/d) were orally administered to male Sprague-Dawley rats after STZ injection and conducted for 8 weeks.