Publications by authors named "Ling-Na Fei"
RNA interference (RNAi) has been proved as a novel approach for gene therapy. However, RNAi mono-therapy only aims at single gene, it therefore may ultimately fail to cure cancers caused by polygene variation. To overcome the deficiency of RNAi mono-therapy, "combinatorial RNA interference" (coRNAi) was put forward as a new strategy.
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- High mobility group A2 protein (HMGA2) is significantly linked to various cancers, especially lung cancer, making it a potential target for treatment.
- RNA interference (RNAi) is a cost-effective and efficient method for gene silencing, which can be harnessed for therapy.
- Five specific siRNAs targeting the HMGA2 gene were tested, with HMGA2 siRNA5 showing the strongest effects on cell growth, migration, and apoptosis in lung cancer cell lines, indicating its potential in gene therapy.