Publications by authors named "Ling-Li He"
Article Synopsis
- The study focuses on the efficient biological nitrogen removal in wastewater treatment using a continuous-flow process with hybrid-inoculated granular sludge.
- Compared to PN/A granular sludge, PN granular sludge has a shorter incubation period and is effective for enriching ANAMMOX bacteria, which enhances nitrogen removal.
- The research showed that while the mix with a different ratio of granular sludges (3:1, 1:1, 1:3) had varying start-up times, they all achieved strong nitrogen removal performance, indicating a successful strategy for developing a continuous-flow nitrogen removal system.
Introduction: We have previously demonstrated the antagonistic role of hydrogen sulfide (H2S) in the cognitive dysfunction of streptozotocin (STZ)-induced diabetic rats. It has been confirmed that the impaired hippocampal autophagic flux has a key role in the pathogenesis of cognitive impairment and that ornithine decarboxylase (ODC)/spermidine (Spd) pathway plays an important role in the formation of memory by promoting autophagic flux.
Objectives: To investigate the roles of hippocampal ODC/Spd pathway and autophagic flux in H2S-attenuated cognitive impairment in STZ-induced diabetic rats.
Bcl-2 inhibitors display an effective activity in acute myeloid leukemia (AML), but its clinical efficacy as a monotherapy was limited in part owing to failure to target other antiapoptotic Bcl-2 family proteins, such as Mcl-1. In this context, the combination strategy may be a promising approach to overcome this barrier. Here, we report the preclinical efficacy of a novel strategy combining ABT-199 with triptolide (TPL), a natural product extracted from a traditional Chinese medicine, in AML.
View Article and Find Full Text PDFChondrocyte apoptosis has been implicated as a major pathological osteoarthritis (OA) change in humans and experimental animals. We evaluate the ability of miR-186 on chondrocyte apoptosis and proliferation in OA and elucidate the underlying mechanism concerning the regulation of miR-186 in OA. Gene expression microarray analysis was performed to screen differentially expressed messenger RNAs (mRNAs) in OA.
View Article and Find Full Text PDFArticle Synopsis
- Methyl tortuoate D was isolated from the soft coral Sarcophyton tortuosum along with five other related bis-cembranoids.
- The structure of methyl tortuoate D was revised based on detailed nuclear magnetic resonance analysis and literature comparison.
- Lobophytone K, isolated from another coral species, was identified as the same compound as methyl tortuoate D, and its absolute configuration was determined using electronic circular dichroism.
[Association of interleukin 28B polymorphisms with response to pegylatedinterferon plus ribavirin therapy for chronic hepatitis C].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2012
Article Synopsis
- The study explored the link between the IL28B rs12979860 gene polymorphism and the effectiveness of antiviral therapy in chronic hepatitis C patients in Sichuan, China, finding a significant association between the IL28B CC genotype and higher treatment success rates.
- Among 56 patients, the majority had the CC genotype (76.8%), with a high sustained virological response (SVR) rate of 82.1%, notably higher in those with the CC genotype compared to the CT genotype (90.7% vs. 53.8%).
- The research indicated that the therapeutic efficacy of PEG-IFN alpha-2a plus RBV was enhanced in patients with the CC genotype, especially those with higher baseline
[Lamivudine-resistant analysis and management for chronic hepatitis B patients with initial lamivudine therapy].
Zhonghua Gan Zang Bing Za Zhi
June 2011
Article Synopsis
- The study examined long-term lamivudine use in chronic hepatitis B patients, focusing on factors influencing its effectiveness and resistance management.
- A total of 383 patients were treated and tracked over 10 years, with 129 developing lamivudine resistance, divided into two treatment groups for further analysis.
- Key findings revealed that a significant proportion achieved HBV DNA negativity and seroconversion after treatment, but high initial viral loads and low ALT levels were linked to higher rates of viral rebound, highlighting the different effectiveness of alternative therapies post-resistance.
Article Synopsis
- The study investigates the relationship between treatment duration and cumulative doses of pegylated interferon alpha-2a (PegIFN alpha-2a) plus ribavirin (RBV) on antiviral therapy effectiveness in 117 patients with hepatitis C.
- Patients were grouped by age, weight, and other factors, with significant findings indicating younger patients and those with shorter infections had higher sustained virological response (SVR) rates.
- Results showed that both treatment length and total cumulative doses of PegIFN and RBV positively correlated with improved SVR rates, with longer treatment periods and higher doses leading to better outcomes.
Article Synopsis
- The study questions the effectiveness of ALT as a predictor of liver injury in chronic hepatitis B patients with ALT levels below twice the upper limit of normal.
- Nearly half of the patients showed significant inflammation and a third showed significant fibrosis, regardless of their ALT levels.
- Advanced age emerged as a key predictor for more severe liver damage, highlighting the importance of liver biopsy for assessing liver health and determining the need for antiviral treatment.
[Analysis of genomic DNA methylation level in radish under cadmium stress by methylation-sensitive amplified polymorphism technique].
Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao
June 2007
Article Synopsis
- The study analyzed how cadmium affects cytosine methylation in radish plants using a technique called methylation-sensitive amplified polymorphism (MSAP).
- Results showed a significant increase in methylation levels with higher cadmium chloride concentrations (50, 250, and 500 mg/L) compared to the control, indicating that new methylation was occurring under cadmium stress.
- Four different methylation patterns were observed in the plants exposed to cadmium, with the primary change being de novo methylation at specific DNA sites.