Publications by authors named "Ling-Jin Tuo"
Various dyes are used to visualize DNA bands in agarose gel electrophoresis (AGE) by the methods of pre- or post-staining. The DNA dye user's guides generally state that the binding of the dye to DNA will affect DNA mobility in electrophoresis, thus recommending post-staining for accurate measurement of DNA size. However, many AGE performers prefer pre-staining procedures for reasons such as convenience, real-time observation of DNA bands, and/or the use of a minimal amount of dye.
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- - This study investigates how maternal vitamin D deficiency (VDD) during pregnancy leads to depression-like behaviors in adult offspring, focusing on changes in DNA methylation in the cortex.
- - Results indicated that offspring from VDD-fed female mice exhibited depression-like behaviors and showed decreased levels of cortical DNA methylation and specific gene expression changes related to depression.
- - Folic acid supplementation during pregnancy was found to counteract the negative effects of VDD by restoring DNA methylation and reducing depression-related gene expression in the adult offspring.