Publications by authors named "Ling-Huan Gao"
Article Synopsis
- - The study focuses on E2F transcription factor 8 (E2F8), highlighting its increased expression in bladder cancer tissues, which correlates with more advanced stages of the disease.
- - Silencing E2F8 in bladder cancer cell lines leads to reduced cell proliferation and invasion, enhances apoptosis in response to cisplatin treatment, and affects the cell cycle by causing G1 phase arrest.
- - E2F8 regulates the expression of MCM7, a factor involved in bladder cancer progression, and their interaction suggests that E2F8’s oncogenic effects may be mediated through MCM7.
Article Synopsis
- Six new grayanane diterpenoids (neopierisoids G-L) were discovered in Pieris japonica flowers, along with ten known compounds.
- The structures of the new compounds were determined using advanced techniques like NMR spectroscopy and mass analysis, with absolute configurations established through X-ray diffraction and CD spectrum comparison.
- The new compounds exhibited significant antifeedant activity against the pest Pieris brassicae, with the study analyzing the relationship between their structures and effectiveness as deterrents.
Objective: To investigate the preventive and therapeutic effect and mechanism of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage.
Methods: Sixty SD rat aged 9-12 weeks were chosen and divided into the control group, model group and simvastatin-treated group randomly with 20 rats in each group. Rats in the model group and simvastatin-treated group were infused with autologous fresh uncoagulated blood to the right brain tissue of the basal ganglia to build the cerebral hemorrhage model, while rats in the control group were treated with the same amount of normal saline.
Antioxidant lignans from the seeds of Vitex negundo var. cannabifolia.
J Asian Nat Prod Res
November 2014
A new phenyldihydronaphthalene-type lignan, vitexdoin F (1), along with 22 known lignan derivatives (2-23) was isolated from the seeds of Vitex negundo var. cannabifolia. Their structures were established by comprehensive 1D and 2D NMR spectroscopic analyses.
View Article and Find Full Text PDFTwo new chlorinated multiacylated 3,4-seco-grayanane diterpenoids, neopierisoids A and B (1 and 2), were isolated from flowers of the poisonous plant Pieris japonica and were identified from spectroscopic analysis and X-ray diffraction data. Both compounds showed obvious antifeedant activity against Pieris brassicae with an EC50 of 10.07 μg/cm(2) for 1 and 5.
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