Publications by authors named "Ling-Feng Zha"
Among the more than 170 known RNA modifications, methylation modification is the most frequent and well-studied. Depending on where the methylation occurs, RNA methylation can be classified as N -methyladenosine, N -methyladenosine, 5-methylcytosine, N -methylguanosine, and others. The methylation of RNA is constantly and dynamically modified in the complex microenvironment by methyltransferases, demethylases, and methylation reading proteins.
View Article and Find Full Text PDFEffects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.
Oxid Med Cell Longev
February 2022
Objectives: Observational studies indicate that insomnia may increase risk of peptic ulcer disease (PUD). Our purpose is to clarify the possible causal relationship between insomnia and PUD by Mendelian randomization analyses.
Methods: We carried out analyses using summary statistics data for genetic variants reported from a GWAS of insomnia ( = up to 1,331,010 individuals) and from a GWAS of PUD ( = up to 456,327 individuals).
Article Synopsis
- The TSLP/TSLPR axis plays a significant role in inflammatory diseases, including coronary artery disease (CAD), with a study analyzing genetic variants in this axis among a large population of CAD patients and controls.
- Three specific genetic variants were found to have a strong association with CAD, with rs3806933 and rs6897932 notably affecting the expression of related genes and potentially increasing plasma TSLP levels.
- The research indicates that these genetic variants, both individually and in combination (particularly with IL-33 signaling), contribute to a heightened risk of developing CAD, suggesting a complex genetic influence on the disease.
Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e.
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