Mechanisms of ammonium detoxification in submerged macrophytes under shade conditions.

Excessive ammonium disrupts the biological and physical characteristics of aquatic freshwater ecosystems, causing nutrient imbalances and toxicity. Different macrophytes exhibit varying tolerance levels to ammonium stress, influenced by species-specific adaptations. However, eutrophic water bodies not only have high nutrient loads but also exhibit low light transparency, necessitating an understanding of how submerged macrophytes cope with both high ammonium concentrations and low light conditions.

Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells.

Aims: Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage is a main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role in FAO dysregulation in tubular cells is not clarified.

Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.

Renal tubular epithelial cell senescence plays a critical role in promoting and accelerating kidney aging and age-related renal fibrosis. Senescent cells not only lose their self-repair ability, but also can transform into senescence-associated secretory phenotype (SASP) to trigger inflammation and fibrogenesis. Recent studies show that mitochondrial dysfunction is critical for renal tubular cell senescence and kidney aging, and calcium overload and abnormal calcium-dependent kinase activities are involved in mitochondrial dysfunction-associated senescence.

Germination Requirement and Suitable Storage Method of Seeds.

Understanding of seed germination requirements and storage methods is very important to successfully conserve and restore aquatic vegetation. The main question addressed by the research was germination requirements and suitable seed storage methods of seeds. Furthermore, the water content and respiration rate of seeds were studied under different storage conditions.

Which Has a Greater Impact on Plant Functional Traits: Plant Source or Environment?

The deterioration of water quality caused by human activities has triggered significant impacts on aquatic ecosystems. Submerged macrophytes play an important role in freshwater ecosystem restoration. Understanding the relative contributions of the sources and environment to the adaptive strategies of submerged macrophytes is crucial for freshwater restoration and protection.

MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity.

Renal fibrosis, with no therapeutic approaches, is a common pathological feature in various chronic kidney diseases (CKD). Tubular cell injury plays a pivotal role in renal fibrosis. Commonly, injured tubular cells exhibit significant lipid accumulation.

The distinctive level of interaction between carbon and nitrogen metabolisms in the leaves of submerged macrophytes plays a key role in ammonium detoxification.

Possible ammonium detoxification mechanisms have been proposed recently, on submerged macrophytes, evidently illustrating that glutamate dehydrogenase (GDH) plays a greater role in ammonium detoxification compared to the primary glutamine synthetase/glutamate oxaloacetate transaminase (GS/GOGAT) pathway. In the current investigation, we cultured three submerged macrophytes to extreme concentrations of [NH-N] of up to 50 mg/L with the aim of clarifying the interaction between carbon and nitrogen metabolisms. The activities of carboxylation enzymes pyruvate orthophosphate dikinase (PPDK) and phosphoenolpyruvate carboxylase (PEPC), in lieu of Rubisco, increased almost two-fold for ammonium tolerant species P.

Negative Effects of Butachlor on the Growth and Physiology of Four Aquatic Plants.

The increasing use of herbicides in intelligent agricultural production is driven by the time-consuming nature of manual weeding, as well as its ephemeral effectiveness. However, herbicides like butachlor degrade slowly and can be washed away by rainwater, ultimately flowing into the farm ponds and posing risks to aquatic plants. To identify and recommend superior restoration strategies that effectively address the challenges posed by butachlor, we investigated the impacts of butachlor on the growth and physiology of four common aquatic plants (i.

Transcriptome Analysis of Macrophytes' Response to Ammonium Nitrogen Stress Using the Whole Plant Individual.

Ammonium toxicity in macrophytes reduces growth and development due to a disrupted metabolism and high carbon requirements for internal ammonium detoxification. To provide more molecular support for ammonium detoxification in the above-ground and below-ground parts of , we separated (using hermetic bags) the aqueous medium surrounding the below-ground from that surrounding the above-ground and explored the genes in these two regions. The results showed an upregulation of asparagine synthetase genes under high ammonium concentrations.

Pentraxin 3 plays a key role in tubular cell senescence and renal fibrosis through inducing β-catenin signaling.

Renal fibrosis is the common pathological feature of various chronic kidney diseases (CKD). Tubular cell senescence plays a key role in the progression of renal fibrosis. However, the underlying mechanisms are still in mystery.

KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging.

Introduction: Aged kidney is characterized by mitochondrial dysfunction, cellular senescence, and fibrogenesis. The activation of Wnt/β-catenin signaling plays an important role in the initiation of kidney aging. However, the inhibiting strategies have not been discovered in detail.

Annexin A2 plays a key role in protecting against cisplatin-induced AKI through β-catenin/TFEB pathway.

Acute kidney injury (AKI) is in high prevalence in the world. However, the therapeutic strategies for AKI are still in mystery. Studies have shown to improve autophagy and lysosomal function could inhibit AKI.

The Above-Ground Part of Submerged Macrophytes Plays an Important Role in Ammonium Utilization.

As a paradoxical nutrient in water ecosystems, ammonium can promote plants growth under moderate concentration, but excess of it causes phytotoxic effects. Previous research has revealed that glutamate dehydrogenase in the above-ground part of submerged macrophytes plays an important role in ammonium detoxification. However, the strategies of ammonium utilization at the whole plant level of submerged macrophytes are still unclear and the role of the above-ground part in nutrient utilization has not been clearly elucidated in previous studies, hence, directly influencing the application of previous theory to practice.

CXC Chemokine Receptor 2 Accelerates Tubular Cell Senescence and Renal Fibrosis β-Catenin-Induced Mitochondrial Dysfunction.

Renal fibrosis is a common feature of various chronic kidney diseases (CKD). However, its underlying mechanism has not been totally clarified. C-X-C motif chemokine receptor (CXCR) family plays a role in renal fibrosis, however, detailed mechanisms have not been elucidated.

Cannabinoid receptor 2 plays a central role in renal tubular mitochondrial dysfunction and kidney ageing.

Kidney is one of the most important organs in maintaining the normal life activities. With the high abundance of mitochondria, renal tubular cell plays the vital role in functioning in the reabsorption and secretion of kidney. Reports have shown that mitochondrial dysfunction is of great importance to renal tubular cell senescence and subsequent kidney ageing.

Exploring the ammonium detoxification mechanism of young and mature leaves of the macrophyte Potamogeton lucens.

Toxicity in aquatic plants, caused by excess ammonium in the environment, is an important ecological problem and active research topic. Recent studies showed the importance of the enzyme Glutamate Dehydrogenase (GDH) in detoxifying ammonium. However, these results mainly derived from species comparisons, hence some mechanisms may have been obscured due to species differences.

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells.

Chronic kidney disease (CKD) has a high prevalence worldwide and is an intricate issue to whole medical society. Renal fibrosis is the common pathological feature for various kinds of CKD. As an anti-aging protein, Klotho is predominantly expressed in renal tubular epithelial cells.

Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating β-catenin signaling.

The endocannabinoid system has multiple effects. Through interacting with cannabinoid receptor type 1 and type 2, this system can greatly affect disease progression. Previously, we showed that activated cannabinoid receptor type 2 (CB2) mediated kidney fibrosis.

Advancements in therapeutic drugs targeting of senescence.

Aging leads to a high burden on society, both medically and economically. Cellular senescence plays an essential role in the initiation of aging and age-related diseases. Recent studies have highlighted the therapeutic value of senescent cell deletion in natural aging and many age-related disorders.

Wnt signaling in kidney: the initiator or terminator?

The kidney is a key organ in the human body that excretes toxins and sustains the water-electrolyte balance. During embryonic development and disease progression, the kidney undergoes enormous changes in macrostructure, accompanied by a variety of microstructural histological changes, such as glomerular formation and sclerosis, tubule elongation and atrophy, interstitial establishment, and fibrosis progression. All of these rely on the frequent occurrence of cell death and growth.

Structural Variability and Functional Prediction in the Epiphytic Bacteria Assemblies of Myriophyllum spicatum.

The underlying principles influencing bacteria community assembly have long been of interest in the field of microbial ecology. Environmental heterogeneity is believed to be important in controlling the uniqueness and variability of communities. However, little is known about the influence of the host macrophytes on epiphytic bacteria assembly.

Glutamate dehydrogenase plays an important role in ammonium detoxification by submerged macrophytes.

Ammonium is a paradoxical chemical because it is a nutrient but also damages ecosystems at high concentration. As the most eco-friendly method of water restoration, phytoremediation technology still faces great challenges. To provide more theoretical support, we exploited six common submerged macrophytes and selected the most ammonium-tolerant and -sensitive species; then further explored and compared the mechanisms underlying ammonium detoxification.

The Analysis of Leaf Traits of Eight Populations and Their Potential Ecosystem Functions in Karst Freshwaters in China.

Submerged macrophytes play a structuring role in the shallow freshwater ecosystem by increasing the heterogeneous state in freshwaters. The macrophytes in genus were featured for their broad leaves, which might consequently produce specialized functions that differed from other submerged species. To explore the potential ecological role of , a field investigation was conducted on leaf traits in eight populations of ranging from the southwestern Yunnan-Guizhou plateau to the southern Hainan island in China covering a distance of >1,700 km.