Publications by authors named "Ling Xia"

Background: Recent advances in deep learning have sparked new research interests in dynamic magnetic resonance imaging (MRI) reconstruction. However, existing deep learning-based approaches suffer from insufficient reconstruction efficiency and accuracy due to the lack of time correlation modeling during the reconstruction procedure.

Purpose: Inappropriate tensor processing steps and deep learning models may lead to not only a lack of modeling in the time dimension but also an increase in the overall size of the network.

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Gold-grafted melamine sponge (AuSp) was fabricated and applied as surface-enhanced Raman spectroscopy (SERS) substrate for enzyme-linked immunoassay of 2 typical mycotoxins, zearalenone (ZEN) and T-2 toxin. The gold nanoparticles were in situ grown on the sponge, and the product showed good effect in enhancing Raman signal and good stability. COMSOL and Gaussian simulations were used to analyze the enhancing effect.

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Article Synopsis
  • - The text discusses how surface-enhanced Raman spectroscopy (SERS) is used to analyze complex natural products, helping in identifying components, ensuring quality control, and understanding action mechanisms.
  • - SERS is highlighted for its effectiveness in identifying active ingredients within complicated mixtures and monitoring production quality, but faces challenges like standardizing substrates and processing data.
  • - Future advancements in SERS will revolve around innovation, automation, and collaborative efforts, aiming to enhance the natural product industry and aid in drug development and quality assurance.
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  • Cardiac conduction velocity (CV) measures how quickly electrical impulses travel through the heart muscle, broken down into longitudinal, transverse, and normal components.
  • * The study reviews CV values from both clinical and experimental investigations of human hearts that have suffered infarcts, as well as data from animal studies.
  • * It aims to provide guidance on CV and conductivity selection for cardiac modeling, with a focus on applications in personalized models for heart rhythm disorders.
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  • Previous studies indicate that both rTMS (repetitive transcranial magnetic stimulation) and tDCS (transcranial direct current stimulation) may effectively treat cognitive impairment in stroke patients, but results have been mixed, prompting this study to conduct a meta-analysis.
  • The meta-analysis used data from various studies published until February 2024 and analyzed it using STATA software, aiming to identify the overall impact of rTMS and tDCS on cognitive function in post-stroke cognitive impairment (PSCI) patients.
  • Results showed that both therapies had a positive effect on cognitive function, with rTMS significantly improving attention, language, and memory, while tDCS notably enhanced executive and visuospatial functions, though
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  • Desertification and wastewater discharge are critical global challenges that impact the sustainable use of natural resources.
  • The study found that using municipal wastewater to cultivate the cyanobacterium Scytonema javanicum initiated the formation of artificial biocrusts in dryland areas, showing promising nutrient retention and photosynthetic activity.
  • The low ecological risk associated with this method indicates its potential for improving soil stability while recycling wastewater, marking an important advancement in sustainable resource management.
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  • Frailty and self-management are critical for quality of life in cancer patients, but their combined effects in older postoperative gynecologic malignancy patients haven't been thoroughly examined.
  • A study conducted on 177 patients over 45 years old revealed a frailty prevalence of 39.5%, with notable scores for self-management and quality of life.
  • Results indicated that self-management acts as a mediator between frailty and quality of life, highlighting the importance of enhancing self-management skills to improve patients' well-being.
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Chiral compounds are abundantly distributed in both the natural world and biological systems. It is crucial to identify and detect chiral compounds in living systems or to separate and determine them in the natural environment. Many researchers have developed a range of chiral materials with different functionalizations to separate and detect chiral substances.

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Objective: Reminiscence therapy is increasingly being utilized for cancer patients to address psychological pressure and enhance their quality of life. This meta-analysis aimed to comprehensively evaluate the effect of a reminiscence therapy-involved program (RTIP) on anxiety, depression, and quality of life in cancer patients.

Methods: A systematic literature search was conducted in the Web of Science, PubMed, Embase, and Cochrane Library databases until December 2023 to screen randomized control trials (RCTs) comparing the effect of RTIP and control care.

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Background: In magnetic resonance imaging (MRI), maintaining a highly uniform main magnetic field (B) is essential for producing detailed images of human anatomy. Passive shimming (PS) is a technique used to enhance B uniformity by strategically arranging shimming iron pieces inside the magnet bore. Traditionally, PS optimization has been implemented using linear programming (LP), posing challenges in balancing field quality with the quantity of iron used for shimming.

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Biomarkers and their concentration levels are critical indicators of metabolomics for clinical applications. Rapid and sensitive analysis methods are essential for realizing timely and efficient quantitation of those significant biomarkers. In this work, a self-driven microfluidic immunosensor was developed for rapid all-in-one separation, enrichment, and detection of biomarkers.

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Soil reconstruction is a critical step in the restoration of environments affected by mining activities. This paper provides a comprehensive review of the significant role that microbial processes play in expediting soil structure formation, particularly within the context of mining environment restoration. Coal gangue and flotation tailings, despite their low carbon content and large production volumes, present potential substrates for soil reclamation.

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Porous cage materials with certain dimensions, sizes, shapes, and functions have been regarded as promising materials for sample preparation, chromatographic separation, and detection process. In contrast to infinite frameworks such as metal-organic frameworks or covalent organic frameworks, porous cage materials are constructed from discrete molecules containing at least one internal cavity. The well-defined cavities in porous cage materials provide opportunities for non-covalent interactions.

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  • Ventricular tachycardia (VT) is a dangerous heart condition often seen in patients with heart attacks, and this study focuses on optimizing computational modeling to analyze it more effectively and efficiently.
  • Researchers created various heart models based on MRI data from six patients and tested these models to see how different mesh sizes affected the accuracy of VT predictions.
  • Results showed that a mesh size of 350 µm provided over 85% accuracy for predicting clinically relevant VT, while larger mesh sizes decreased prediction accuracy, emphasizing the importance of balancing computational resources with model precision.
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Understanding the vascular formation and distribution in metastatic lung tumors is a significant challenge due to autofluorescence, antibody/dye diffusion in dense tumor, and fluorophore stability when exposed to solvent-based clearing agents. Here, an approach is presented that redefines 3D vasculature imaging within metastatic tumor, peritumoral lung tissue, and normal lung. Specifically, a far-red aggregation-induced emission nanoparticle with surface amino groups (termed as TSCN nanoparticle, TSCNNP) is designed for in situ formation of hydrogel (TSCNNP@Gel) inside vasculatures to provide structural support and enhance the fluorescence in solvent-based tissue clearing method.

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Objectives: Previous studies have shown that microstructural alterations in white matter (WM) could contribute to the symptom manifestation and support the dysconnectivity hypothesis in schizophrenia patients. These alterations were pervasive, non-specific, and reported inconsistently across the literature. This study aimed to specifically investigate the microstructure alterations of the posterior limb of the internal capsule (PLIC) in first-episode, drug-naive schizophrenia patients.

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O157:H7 is one of the most susceptible foodborne pathogens, easily causing food poisoning and other health risks. It is of great significance to establish a quantitative method with higher sensitivity and less time consumption for foodborne pathogens analysis. The Raman-silent signal has a good performance for avoiding interference from the food matrix so as to achieve accurate signal differentiation.

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Early diagnosis of abnormal electrocardiogram (ECG) signals can provide useful information for the prevention and detection of arrhythmia diseases. Due to the similarities in Normal beat (N) and Supraventricular Premature Beat (S) categories and imbalance of ECG categories, arrhythmia classification cannot achieve satisfactory classification results under the inter-patient assessment paradigm. In this paper, a multi-path parallel deep convolutional neural network was proposed for arrhythmia classification.

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Soil formation is a complex process that starts from the biological development. The ecological principles and biological function in soil are of great importance, whereas their response to anthropogenic intervention has been poorly understood. In this study, a 150-day microcosmic experiment was conducted with the addition of sludge and/or fermented wood chips (FWC) to promote the soil maturation.

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Article Synopsis
  • * A novel hollow core-shell structure was developed to enhance the performance of FeO nanozymes, resulting in a nanocomposite (p-FeO@PDA@ZIF-67) that effectively improves sensor sensitivity.
  • * This study represents a breakthrough in nanozyme technology, showcasing how structural design can lead to enhanced catalytic activity and better detection capabilities in complex environments.
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Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance to ferroptosis, while enhanced IRE1α expression promotes sensitivity to ferroptosis.

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Myocardial infarction (MI) is one of the most threatening cardiovascular diseases. This paper aims to explore a method for using an algorithm to autonomously classify MI based on the electrocardiogram (ECG).A detection method of MI that fuses continuous T-wave area (C_TWA) feature and ECG deep features is proposed.

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  • * The paper categorizes COF nanozymes into three types and highlights their benefits, such as more active sites and better stability compared to traditional methods.
  • * It also covers the synthesis methods for COF nanozymes, compares their performances, and explores their applications in areas like environmental analysis, food safety, and medical diagnostics, while addressing future prospects and challenges.
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  • This paper introduces a new approach using physics-informed neural networks for magnetic resonance electrical property tomography (MREPT), which is a noninvasive way to assess the electrical properties of tissues during MRI scans.
  • The proposed method aims to overcome issues faced by traditional MREPT methods, like artifacts from simplifying assumptions and errors from numerical differentiation, by applying a model-driven technique based on fully connected neural networks (FCNNs).
  • To improve results, the approach includes additional constraints to ensure the consistency of electrical properties, and it has been tested using realistic simulations and experiments with a high-field animal MRI system.
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Synopsis of recent research by authors named "Ling Xia"

  • - Ling Xia's recent research spans multiple interdisciplinary fields, including environmental science, cancer care, and advanced materials, highlighting innovative approaches to pressing global challenges such as desertification, wastewater treatment, and healthcare quality.
  • - Notable findings include the induction of artificial biocrusts using municipal wastewater to enhance dryland soils, revealing a potential solution for nutrient transfer and land restoration, and a significant meta-analysis that corroborates the effectiveness of reminiscence therapy in alleviating anxiety and depression among cancer patients.
  • - Xia's work also delves into the development of advanced analytical tools, such as microfluidic immunosensors and hybrid modeling techniques for medical imaging, contributing to improvements in early disease detection and enhancing diagnostic capabilities in various medical fields.

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