Publications by authors named "Ling Ting"

Glutamine synthetase (GS), the only enzyme responsible for de novo glutamine synthesis, plays a significant role in cancer progression. As an example of the consequences of GS mutations, the R324C variant causes congenital glutamine deficiency, which results in brain abnormalities and neonatal death. However, the influence of GS-deficient mutations on cancer cells remains relatively unexplored.

View Article and Find Full Text PDF
Article Synopsis
  • Current methods for measuring bioavailable phosphorus (BAP) in rivers are time-consuming due to sediment separation, which hinders routine analysis.
  • The study proposes a new method using simultaneous multisample ultrasonic extraction to directly measure total BAP in river water without separating sediment.
  • Results showed this new method produced comparable BAP concentrations to traditional methods but significantly reduced analysis time, making it practical for routine river water testing.
View Article and Find Full Text PDF

Glutamine synthetase (GS) is a crucial enzyme involved in de novo synthesis of glutamine and participates in several biological processes, including nitrogen metabolism, nucleotide synthesis, and amino acid synthesis. Post-translational modification makes GS more adaptable to the needs of cells, and acetylation modification of GS at double sites has attracted considerable attention. Despite very intensive research, how SUMOylation affects GS activity at a molecular level remains unclear.

View Article and Find Full Text PDF

Background: The role of environmental contamination in COVID-19 transmission within hospitals is still of interest due to the significant impact of outbreaks globally. However, there is a scarcity of data regarding the utilization of environmental sampling for informing infection control measures during SARS-CoV-2 outbreaks.

Methods: This retrospective study analyzed incident event investigations conducted at a single center from May 1, 2021, to August 31, 2021.

View Article and Find Full Text PDF

Retinoic acid-inducible gene I (RIG-I) is a cytosolic viral RNA receptor. Upon viral infection, the protein recognizes and then recruits adapter protein mitochondrial antiviral signaling (MAVS) protein, initiating the production of interferons and proinflammatory cytokines to establish an antiviral state. In the present study, we identify zinc finger protein 205 (ZNF205) which associates with RIG-I and promotes the Sendai virus (SeV)-induced antiviral innate immune response.

View Article and Find Full Text PDF

GPR35, a member of the orphan G-protein-coupled receptor, was recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by antagonists can inhibit its pro-cancer role has yet to be answered. We applied antagonist CID-2745687 (CID) in established GPR35 overexpressing and knock-down CRC cell lines to understand its anti-cell proliferation property and the underlying mechanism.

View Article and Find Full Text PDF

Background: Melioidosis is a systemic and suppurative disease endemic in the Southeast Asia. In Taiwan, most cases are reported in the southern region and no relevant profiles have been reported in central region. In this study, we performed the epidemiologic and clinical analyses from the melioidosis cases in central Taiwan.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzed the trophic niches of three rockfish species in the Zhongjieshan Islands during summer 2020, using carbon and nitrogen stable isotopes to understand their dietary relationships.
  • Significant differences were found in δC and δN values among the species, with one species showing the highest ecological diversity and generalized diet.
  • The primary carbon source for these fish was identified as suspended particulate organic matter (POM), which accounted for over 57% of their total dietary intake, highlighting the species' roles in the local marine food web.
View Article and Find Full Text PDF

Human epidermal growth factor receptor (EGFR) is involved in strong association with malignant proliferation, which has been shown to play a central role in the development and progression of non-small cell lung cancer and other solid tumors. The tumor-suppressor protein MIG6 is a negative regulator of EGFR kinase activity by binding at the activation interface of asymmetric dimer of EGFR kinase domain to disrupt EGFR dimerization and then inactivate the kinase. The protein adopts two discrete fragments 1 and 2 to directly interact with EGFR.

View Article and Find Full Text PDF

PLIN2 has been found to be dysregulated in several human malignancies, which influences cancer progression. However, the roles of PLIN2 in regulating hepatocellular carcinoma (HCC) progression are still unclear. Here, we revealed that PLIN2 was frequently upregulated in HCC cells and tissues, and increased PLIN2 expression was associated with poor prognosis outcomes in HCC.

View Article and Find Full Text PDF

Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regulation remain unclear. Here, we show that intracellular MDK interacts with LKB1 and STRAD to disrupt the LKB1-STRAD-Mo25 complex.

View Article and Find Full Text PDF

Mitochondrial antiviral signaling protein (MAVS), an adaptor protein, is activated by RIG-I, which is critical for an effective innate immune response to infection by various RNA viruses. Viral infection causes the RIG-I-like receptor (RLR) to recognize pathogen-derived dsRNA and then becomes activated to promote prion-like aggregation and activation of MAVS. Subsequently, through the recruitment of TRAF proteins, MAVS activates two signaling pathways mediated by TBK1-IRF3 and IKK- NF-κb, respectively, and turns on type I interferon and proinflammatory cytokines.

View Article and Find Full Text PDF
Article Synopsis
  • Phycospheric bacteria play a crucial role in enhancing the growth of algae, but research on their interactions is limited.
  • A marine heterotrophic bacterium has been shown to boost algal growth while reducing stress-related activities, such as superoxide dismutase (SOD) and non-photochemical quenching (NPQ).
  • The study reveals that co-culturing with this bacterium leads to a significant increase in algae's photosynthesis and biosynthesis processes, suggesting potential benefits for aquaculture systems through mutualistic relationships.
View Article and Find Full Text PDF

Placenta growth factor (PlGF) is a pro-inflammatory angiogenic mediator that promotes many pathologies including diabetic complications and atherosclerosis. Widespread endothelial dysfunction precedes the onset of these conditions. As very little is known of the mechanism(s) controlling PlGF expression in pathology we investigated the role of hyperglycaemia in the regulation of PlGF production in endothelial cells.

View Article and Find Full Text PDF

Metabolite-protein interactions (MPIs) play key roles in cancer metabolism. However, our current knowledge about MPIs in cancers remains limited due to the complexity of cancer cells. Herein, the authors construct an integrative MPI network and propose a MPI network based hepatocellular carcinoma (HCC) subtyping and mechanism exploration workflow.

View Article and Find Full Text PDF

Retinoic acid-inducible gene I (RIG-I) plays a critical role in the recognition of intracytoplasmic viral RNA. Upon binding to the RNA of invading viruses, the activated RIG-I translocates to mitochondria, where it recruits adapter protein MAVS, causing a series of signaling cascades. In this study, we demonstrated that Hsp70 binding protein 1 (HSPBP1) promotes RIG-I-mediated signal transduction.

View Article and Find Full Text PDF
Article Synopsis
  • Activated RIG-I detects viral RNA and recruits the adaptor protein VISA, which connects RIG-I to downstream signaling proteins for immune response.
  • The process activates key kinases like TBK1 and IKK, resulting in the phosphorylation of transcription factors IRF3/7 and NF-κB, which trigger antiviral gene expression.
  • The mitochondrial isoform DUT-M enhances this signaling by promoting the interaction between RIG-I and VISA, leading to improved immune responses against RNA viruses.
View Article and Find Full Text PDF

Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple-negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency. Studies have shown that the use of alternative energy sources, such as fatty acids, enables tumor cells to continue to proliferate rapidly in a glutamine-deficient microenvironment.

View Article and Find Full Text PDF

E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase and directly binds to substrates by various specific domains. According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with uncharacterized domains (FBXO).

View Article and Find Full Text PDF

Background: Inadequate hospital cleaning may contribute to cross-transmission of pathogens. It is important to implement effective cleaning for the safe hospital environment. We conducted a three-phase study using human factors engineering (HFE) approach to enhance environmental cleanliness.

View Article and Find Full Text PDF
Article Synopsis
  • Ubiquitin-specific-processing proteases (USPs) are important enzymes in cancer, yet their potential in clinical settings is limited due to insufficient understanding of their functions and interactions.
  • A comprehensive study analyzed 54 USPs across 29 cancer types using multi-omics data, revealing that while mutations are rare, many USPs show notable expression changes and have significant links to cancer prognosis and key biological pathways.
  • The research also identified new interactions between USPs and their substrates, illustrating how these interactions can lead to distinct cancer subtypes with varying prognoses, ultimately enhancing our understanding of USPs in cancer mechanisms.
View Article and Find Full Text PDF

Algal cultures are generally co-cultures of algae and bacteria, especially when considering outdoor cultivation. However, the effects of associated bacteria on algal growth remain largely unexplored, particularly in the context of . In the present study, we investigated the effects of antibiotic on the growth of and its associated bacterial community.

View Article and Find Full Text PDF

Retinoic acid-inducible gene-I (RIG-I) belongs to the RIGI-like receptors (RLRs), a class of primary pattern recognition receptors. It senses viral double-strand RNA in the cytoplasm and delivers the activated signal to its adaptor virus-induced signaling adapter (VISA), which then recruits the downstream TNF receptor-associated factors and kinases, triggering a downstream signal cascade that leads to the production of proinflammatory cytokines and antiviral interferons (IFNs). However, the mechanism of RIG-I-mediated antiviral signaling is not fully understood.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionv81g9sg4qp0c2d917g0afqrgb3sv3nnr): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once