Publications by authors named "Ling Su"

Objective: In today's fast-paced society, stress has become a widespread phenomenon, garnering increasing attention for its impact on cancer. This study aims to investigate the current status and research hotspots of chronic stress in cancer research from 2014 to 2024, with the goal of providing valuable insights for future studies.

Methods: We retrieved 618 articles published between 2014 and 2024 from the Web of Science database and analyzed them using R software, VOSviewer, and CiteSpace.

View Article and Find Full Text PDF
Article Synopsis
  • The study examines the adverse events (AEs) linked to clarithromycin, an antibiotic, across different age groups using data from the FDA Adverse Event Reporting System (FAERS).
  • Common AEs include vomiting and diarrhea in younger age groups, while older adults experience issues like abnormal taste and drug interactions.
  • Eighteen age-specific signals were identified, highlighting the need for tailored monitoring and management of clarithromycin's safety profile in different age demographics.
View Article and Find Full Text PDF

Purpose: This study investigates the potential association between commonly prescribed psychotropic medications, such as Atypical Antipsychotics (AAs), Selective Serotonin Reuptake Inhibitors (SSRIs), and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), and congenital anomalies in newborns. The analysis uses data from the Food and Drug Administration Adverse Event Reporting System (FAERS).

Methods: Spontaneously reported cases of congenital anomalies in newborns (under 28 days old) were extracted from the FAERS database, covering January 2004 to June 2023.

View Article and Find Full Text PDF

polysaccharides (FLP1s) have potential biological activities. Our previous study showed that FLP1s positively regulated gut immunity and microbiota. However, it is still unclear whether FLP1s mediate gut microbiota in immunosuppressed mice.

View Article and Find Full Text PDF

Background: Cardiovascular drugs can cross the placenta during pregnancy, potentially exposing the fetus to teratogenic effects. However, ethical constraints on clinical trials with pregnant women limit safety data and result in inadequate drug labeling.

Research Design And Methods: Using the FAERS database (2004-2023), we conducted a retrospective pharmacovigilance study analyzing adverse event reports involving congenital anomalies in newborns (<28 days).

View Article and Find Full Text PDF

In this study, a novel polysaccharide (AHP) from Auricularia auricula was isolated and purified, showing protective effects against CTX-induced liver injury in mice. To study the action mechanism of AHP, a liver injury model was established by intraperitoneally injection 80 mg/kg of CTX for 3 consecutive days. The focus was on how AHP regulated the gut bacteriome and mycobiome to help alleviate metabolic disorders associated with liver injury.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate the connection between incretin therapies (DPP-4 inhibitors and GLP-1 receptor agonists) and hepatobiliary adverse events (hAEs) using data from the FDA's Adverse Event Reporting System (FAERS).
  • It analyzed 68,351 case reports, revealing that 1,327 cases (about 1.94%) reported hepatobiliary issues, with DPP-4 inhibitors linked to significant events like cholelithiasis and cholecystitis, while GLP-1 agonists showed weaker associations.
  • The findings suggest a positive correlation between the use of incretin therapies and hepatobiliary complications, with stronger correlations observed for specific drugs like lirag
View Article and Find Full Text PDF
Article Synopsis
  • Azithromycin and clarithromycin, used for treating pneumonia in older adults (≥65), have been analyzed for associated adverse events (AEs) through the FDA's FAERS database to enhance clinical management.
  • Over 4,400 reports of AEs were reviewed; notable concerns included off-label use and drug interactions, with azithromycin showing significant cardiac risks, while clarithromycin was linked more to drug interactions and psychiatric symptoms.
  • The study highlights the importance of recognizing AEs not mentioned in drug package inserts, aiming to improve treatment decisions for older patients.
View Article and Find Full Text PDF

Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertain. In this multicentre, randomised, double-blind, placebo-controlled trial, we randomly assigned 968 patients with mild-to-moderate COPD to treatment with N-acetylcysteine (600 mg, twice daily) or matched placebo for two years.

View Article and Find Full Text PDF

This study investigated the structure of polysaccharide (POP-1) and its effect on immunocompromised mice induced by cyclophosphamide (CY). Novel POP-1 was α- and β-glucopyranose, its molecular weight was 4.78 × 104 Da, it was mainly composed of glucose (88.

View Article and Find Full Text PDF

This study explores the novel immunomodulatory effects of polysaccharides from the rare Floccularia luteovirens, a fungus with significant potential yet unexplored bioactive components, traditionally used in Tibetan medicine. This study employs a wide array of analytical techniques, including HPGPC, HPLC, western blotting, ELISA, and 16S rRNA gene sequencing, to comprehensively investigate FLP1's effects. The main structure of FLP1 was characterized by IF-TR and NMR spectrometry.

View Article and Find Full Text PDF

RNA splicing is a dynamic molecular process in response to environmental stimuli and is strictly regulated by the spliceosome. Sm proteins, constituents of the spliceosome, are key components that mediate splicing reactions; however, their potential role in hepatocellular carcinoma (HCC) is poorly understood. In the study, SNRPD2 (PD2) is found to be the most highly upregulated Sm protein in HCC and to act as an oncogene.

View Article and Find Full Text PDF
Article Synopsis
  • Three chromomycin derivatives were identified from soil bacteria, specifically chromomycins A and monodeacetylchromomycin A, with their structures and absolute configurations analyzed using advanced techniques like NMR.
  • These compounds demonstrated strong cytotoxic effects against various non-small-cell lung cancer (NSCLC) cells and were found to lower the protein levels of c-FLIP in one of the cancer cell lines.
  • In animal studies, the chromomycins were more effective at inhibiting tumor growth in specific conditions, indicating that c-FLIP plays a significant role in the anticancer activity of these compounds.
View Article and Find Full Text PDF

Background: L-Theanine, a nonproteinogenic amino acid derived from green tea, is being recognized as an anti-cancer candidate. However, it's roles in the development of cancer chemoresistance is still unknown and the molecular mechanism is urgently to be explored.

Methods: The effects of L-Theanine on lung cancer chemoresistance were validated by Cell Counting Kit-8 (CCK-8) assay, transwell assay, and tumor spheroid formation assay; the expression of proteins was detected by using polymerase chain reaction (PCR) and western blotting.

View Article and Find Full Text PDF

Grapevine () is one of the major economic fruit crops but suffers many diseases, causing damage to the quality of grapes. Strain G166 was isolated from the rhizosphere of grapevine and was found to exhibited broad-spectrum antagonistic activities against fungal pathogens on grapes in vitro, such as , and . Whole-genome sequencing revealed that G166 contained a 6,613,582 bp circular chromosome with 5749 predicted coding DNA sequences and an average GC content of 60.

View Article and Find Full Text PDF
Article Synopsis
  • * It involved two stages: one for developing the indicators through literature reviews and expert consultations, and another for analyzing the weights of these indicators using expert opinions and analytical methods.
  • * The finalized set includes three main indicators, with 'Organizational performance' being the most important, while continuous evaluation of these indicators requires ongoing data collection for optimization.
View Article and Find Full Text PDF

XPS, GPC, FT-IR, and GC-MS analyses were conducted on corn straw tar and 70# petroleum asphalt. The results indicate that the sulfur content in corn straw tar is lower than that in petroleum asphalt, potentially mitigating the volatilization of harmful substances upon substituting petroleum asphalt. This finding serves as evidence for the substantial presence of phenolic substances in corn straw tar.

View Article and Find Full Text PDF

Background: Methylmalonic aciduria (MMA) is a group of rare genetic metabolic disorders resulting from defects in methylmalonyl coenzyme A mutase (MCM) or intracellular cobalamin (cbl) metabolism. MMA patients show diverse clinical and genetic features across different subtypes and populations.

Methods: We retrospectively recruited 60 MMA patients from a single center and diagnosed them based on their clinical manifestations and biochemical assays.

View Article and Find Full Text PDF

Background: Men who have sex with men (MSM) is one main type of high-risk activities facilitating HIV-1 transmission in Sichuan province. Previous works on HIV-1 incidence and prevalence among MSM only concentrated before 2018, the situation after that is unknown. In addition, the distribution of hot-spots related to current HIV-1 epidemic is also rarely known among MSM in Sichuan.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined newly diagnosed HIV patients and ART failure patients in rural Sichuan, a region with a severe HIV epidemic in China, aiming to analyze HIV-1 molecular networks and factors influencing network entry.
  • Researchers used advanced genetic analysis methods to assess 530 blood samples, ultimately producing 518 valid sequences that revealed six HIV genotypes, with the most common being CRF01_AE.
  • Findings highlighted that individuals over 50 years old and certain HIV subtypes presented varying risks of network entry, indicating a need for targeted prevention strategies in the diverse HIV infection landscape of rural Sichuan.
View Article and Find Full Text PDF

Primary cilia are enriched in signaling receptors, and defects in their formation or function can induce conditions such as polycystic kidney disease, postaxial hexadactyly, and microphthalmia. Mammalian Hedgehog (Hh) signaling is important in the development of primary cilia, and TMEM216, a transmembrane protein that localizes to the base of cilia, is also implicated in ciliogenesis in zebrafish. Here, we found that -deficient mice had impaired Hh signaling and displayed typical ciliopathic phenotypes.

View Article and Find Full Text PDF

Background: Delirium is a common and severe complication in intensive care unit (ICU) patients with acute ischemic stroke, exacerbating cognitive and physical impairments. It prolongs hospitalization, increases healthcare costs, and raises mortality risk. Early prediction is crucial because it facilitates prompt interventions that could possibly reverse or alleviate the detrimental consequences of delirium.

View Article and Find Full Text PDF

This study estimated and compared mortality risks among people living with HIV (PLWH) under the real-world and hypothetical scenarios of PM concentrations and HIV severity. An open cohort from all PLWH receiving antiretroviral therapy in Sichuan during 2010-2019 was constructed, resulting in 541,515 person-years. Annual mean concentrations of PM were estimated and linked to PLWH by their residential address.

View Article and Find Full Text PDF

This study's objective was to examine the protective effect and mechanism of a novel polysaccharide (AYP) from var. Li. on alcoholic liver disease in mice.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionc99u6afha6k1o51elfb2v8pu4t1o3u66): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once