Publications by authors named "Ling Pan"

Luminescent silver clusters that are confined inside porous zeolites have attracted great research interest due to the combined advantages of high quantum yield, tunable emission, excellent chemical stability, and desirable adoption ability of this micronano-composite. In this research, a series of Ag-exchanged R-LTA/Ag (R = Li, Na, K) zeolites were synthesized, in which the silver clusters showed blue-shifted excitation in the UV region, red-shifted emission in the visible region, and decreased emission intensity when taking Li, Na, and K as the extra-framework cations, respectively. The [Ag(HO)R-sod] ( = 2, 4; R = Li, Na, K) structures were constructed, and the TD-DFT method was further carried out to study the influence of extra-framework cations on the luminescence performance of [Ag] clusters, in which the substitution of Al for Si and the reasonable hydrate levels were both taken into consideration.

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Paspalum vaginatum, valued for its salt tolerance, is a vital species in the turfgrass and agricultural industries. Despite its significance, there are still gaps in its genetic composition, particularly in the mitochondrial (mtDNA) and chloroplast (cpDNA) genomes. Our study aimed to fill these knowledge gaps by investigating the evolutionary relationships within the paspalum family and examining the functions of organelle-encoded genes as well as the critical role of reactive oxygen species (ROS) in organelle-nucleus communication.

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The main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs). In addition to this, it has been observed that tRNAs undergo precise cleavage at specific loci, giving rise to an extensive array of distinct small RNAs, termed tRNA-derived small RNAs (tsRNAs). Existing studies have shown that tsRNAs are widely present across various organisms and comprehensively regulate gene expression, aberrant expression of tsRNAs is inextricably linked to tumorigenesis and development, thus, a systematic understanding of tsRNAs is necessary.

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As a significant variant of the Michael reaction, the 1,6-addition reaction has undergone considerable development over the past decade. This effective strategy enables the synthesis of a variety of novel and potentially bioactive functional molecules. In this review, we summarize the recent progress in NHC-catalyzed 1,6-addition reactions, highlighting their efficiency in the rapid synthesis of complex functional molecules.

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Article Synopsis
  • People with diabetes have a significantly higher risk of developing acute kidney injury (AKI), and low levels of vitamin D (25(OH)D) further increase this risk.
  • A study of 347 diabetes patients found that those with higher baseline 25(OH)D levels had a much lower risk of AKI and needing dialysis compared to those with low levels.
  • Additionally, AKI patients with vitamin D deficiency faced a much greater risk of progressing to end-stage renal disease or even death within six months.
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The cell transition from an inflammatory phase to a subsequent proliferative phase is crucial for wound healing, yet the driving mechanism remains unclear. By profiling lncRNA expression changes during human skin wound healing and screening lncRNA functions, we identify SNHG26 as a pivotal regulator in keratinocyte progenitors underpinning this phase transition. Snhg26-deficient mice exhibit impaired wound repair characterized by delayed re-epithelization accompanied by exacerbated inflammation.

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Article Synopsis
  • - The study aims to explore mRNA biomarkers and the mechanisms behind acute cognitive impairment in elderly patients, particularly through a mouse model, due to the lack of standardized diagnostic tools.
  • - Researchers performed bioinformatics analysis on mouse brain injury data, identifying 102 upregulated and 32 downregulated genes related to immune response and cytokine interactions, indicating their potential role in cognitive impairment.
  • - Five significant hub genes (Cxcl10, Cxcl12, Cxcr3, Gbp2, and Ifih1) were linked to immune cell types, highlighting immune cell infiltration—specifically M1 macrophages and various T cells—as influential factors in the development of cognitive impairment.
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: The aim of the present study was to conduct a meta-analysis of observational studies to explore the latest evidence on the influence of whole grain and fiber consumption on total chronic liver diseases. : We searched the PubMed and Web of Science online databases and reference lists of eligible articles up to June, 2024. : The odds ratio (OR) between whole grain intake and total chronic liver disease risk was 0.

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Background: Chromosomal 1q gains and amplifications (+1q21) are frequently observed in patients with newly diagnosed multiple myeloma (NDMM). However, the interpretation of the high-risk (HR) prognostic implications stemming from 1q21 abnormalities remain challenging to implement effectively.

Methods: In a comprehensive analysis of 367 consecutive patients with symptomatic MM, we assessed the prognostic significance of +1q21 using FISH with a threshold of 7.

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Purpose: The purpose of this study was to investigate the correlation between podocyte related biomarker cofilin-1 and renal function, and explore the value of cofilin-1 in predicting the risk of renal adverse prognosis in IgA nephropathy (IgAN).

Methods: Patients with primary IgAN diagnosed by initial renal biopsy performed in our hospital from January 2019 to February 2022 were included. This study was a prospective cohort study.

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Due to the repeated changes in the COVID-19 pandemic, we live in an era of various uncertainties that raise future anxiety and behavioral addiction problems. According to the Protection Motivation Theory (PMT), the present study attempted to explore the impact of COVID-19 intolerance of uncertainty (COVID-19 IU) on internet addiction (IA) among college students and the mediating role of future anxiety (FA) by constructing a mediating model. A questionnaire survey was conducted on 679 Chinese college students and PROCESS 3.

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Objective: The aim of this study was to investigate the characteristics and related functional pathways of the gut microbiota in patients with IgA nephropathy (IgAN) through metagenomic sequencing technology.

Methods: We enrolled individuals with primary IgAN, including patients with normal and abnormal renal function. Additionally, we recruited healthy volunteers as the healthy control group.

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Introduction: The mental health (MH) of college students has long been a crucial concern for families, educational institutions, and society. Extensive research has demonstrated the influential role of exercise motivation in shaping MH. However, further investigation is warranted to ascertain which types of exercise motivation may have more influence on the MH of college students.

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Although the significant strides in novel therapeutic approaches have prolonged the survival of multiple myeloma (MM) patients, the unfavorable prognosis of cytogenetically high-risk newly diagnosed MM (NDMM) remains intractable with the lack of consensus regarding the choice of maintenance regimens. Therefore, this study was initiated with the aim of examining the effectiveness of various maintenance treatments for this group of patients in jeopardy. Overall, 17 studies with 1937 high-risk NDMM patients were included in the network meta-analysis.

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The effects and underlying mechanisms of metformin which can improve glucose homeostasis of fish have rarely been explored. This experiment aimed to explore the influence of metformin on growth performance, body composition, liver health, hepatic glucolipid metabolic capacity and IR/PIK/AKT pathway in grass carp (Ctenopharyngodon idella) fed high-carbohydrate diets. A normal diet (Control) and high carbohydrate diets with metformin supplementation (0.

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Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has different epidemiology in Chinese vs. Western patients, but there are few studies of CLL/SLL in large populations of Chinese patients. ALPINE is a global phase 3 trial investigating Bruton tyrosine kinase inhibitors zanubrutinib vs.

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Background: The development of tyrosine kinase inhibitor (TKI) therapy has positively impacted the survival rates of patients with chronic myeloid leukemia (CML). It is common in medical practice to adjust the dosage of TKI downward because of TKI-associated adverse events, financial burden, comorbidity, or an attempt at treatment-free remission.

Objectives: This investigation sought to explore the feasibility of employing a reduced dosage of TKI for treating CML.

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Recent studies showed that patients with iron overload had increased risk of insulin resistance or diabetes. Ferroptosis is a new type of cell death mainly caused by iron-dependent oxidative damage. In the present study, we investigated potential mechanisms of iron overload induced hepatic ferroptosis and insulin resistance through in vivo and in vitro experiments.

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Rationale & Objective: The Kidney Failure Risk Equations have been proven to perform well in multinational databases, whereas validation in Asian populations is lacking. This study sought to externally validate the equations in a community-based chronic kidney disease cohort in China.

Study Design: A retrospective cohort study.

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Due to the refractory of 1 H-1,2,4-triazole (TZ), conventional anaerobic biological treatment technology is usually restricted by low removal efficiency and poor system stability. In this study, TZ biodegradation and nitrate reduction was coupled to improve the removal efficiency of TZ from polluted wastewater. Batch assay was performed with pure culture strain Raoultella sp.

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Article Synopsis
  • A study was conducted to compare therapy responses and outcomes among four medications (nilotinib, dasatinib, flumatinib, and imatinib) for newly diagnosed chronic myeloid leukemia (CML) in a practical setting.
  • Data from 2,496 patients across 77 centers in China were analyzed, and results showed that the newer treatments had similar effectiveness in terms of overall survival and progression-free survival, but better initial responses and failure-free survival compared to imatinib.
  • The findings suggest that while nilotinib, dasatinib, and flumatinib are more effective in achieving early treatment responses, all four medications ultimately offer comparable long-term survival outcomes, which can help
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Direct alkene C-H/N-H cross dehydrogenative coupling is an infrequent, highly challenging transformation. Herein, a photoredox radical-radical cross-coupling reaction between ketene dithioacetal as a persistent alkene radical cation and azole nitrogen center radical (NCR) was developed. This direct alkene amination proceeded through a synergistic photoredox and cobalt catalysis, with only H evolution.

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