Publications by authors named "Ling Lu"

Objective: Epithelial-mesenchymal transition (EMT) of alveolar epithelial cells is an important mechanism for the onset and development of broncho-pulmonary dysplasia (BPD).The role of FGF-2 in BPD is currently unclear. The aim of our study is to investigate the expression of FGF-2 in lung tissue of BPD mice, to further clarify the effect of FGF-2 on EMT in alveolar epithelial cells and to actively search for possible signaling pathways.

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Hearing loss, affecting over 466 million people worldwide, poses significant challenges for affected individuals, their families, and healthcare providers alike [...

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Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions. However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. Distinguishing specific TI-Treg subpopulations from peripheral Tregs and intratumoral conventional T cells (Tconvs) has recently emerged as an important topic in antitumor therapy.

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Well-conserved mitogen-activated protein kinase (MAPK) cascades are essential for orchestrating of a wide range of cellular processes in plants, including defense responses against pathogen attack. NAC transcription factors play important roles in plant immunity, but their targets and how they are regulated remain largely unknown. Here, we identified the transcription factor OsNAC29 as a key component of a MAPK signaling pathway involved in rice (Oryza sativa) disease resistance.

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Based on the data of China's listed companies from 2000 to 2022, this study investigates how company misconduct affect company survival risk through survival analysis. The research results show that company misconduct significantly increases company survival risk. After considering endogeneity issues and conducting robustness tests, this conclusion still holds.

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  • Polycystic ovary syndrome (PCOS) affects 8-13% of women in their reproductive years and is commonly treated with off-label drugs that can have side effects; this study investigates curcumin's therapeutic effects in a PCOS rat model.
  • The PCOS model was created using dehydroepiandrosterone (DHEA), followed by curcumin treatment, which assessed changes in ovarian morphology, hormone levels, and oxidative stress markers.
  • Results showed that curcumin improved hormone levels, restored normal ovarian function, and reduced oxidative stress, suggesting its potential as a treatment for PCOS by enhancing PPAR-γ levels.
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Objective: This systematic review and meta-synthesis aimed to explore the experiences of parents making end-of-life decisions in Neonatal Intensive Care Unit (NICU).

Methods: We searched nine databases up to December 2023, including qualitative studies focused on parents' experiences with end-of-life decisions in NICU. Methodological quality was assessed using the Joanna Briggs Institute critical appraisal tool for qualitative research.

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Objective: Hec1 is a component of the Ndc80 kinetochore complex and is frequently upregulated in various cancers. However, the clinical significance of Hec1 in cervical cancer remains largely unknown. This study aimed to investigate the expression patterns of Hec1 in cervical cancer and its relationship with the clinicopathological characteristics of patients diagnosed with the disease.

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Background: Acute pancreatitis (AP) is a rare but serious complication in patients diagnosed with hemorrhagic fever with renal syndrome (HFRS). When AP complicates HFRS, the clinical outcome significantly worsens and the risk of mortality increases. However, the incidence of AP in HFRS patients and its associated mortality risk remain unclear.

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Macrophages are essential for the development of steatosis, hepatic inflammation, and fibrosis in metabolic dysfunction-associated steatohepatitis(MASH). However, the roles of macrophage E2F2 in the progression of MASH have not been elucidated. This study reveals that the expression of macrophage E2F2 is dramatically downregulated in MASH livers from mice and humans, and that this expression is adversely correlated with the severity of the disease.

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Exosome-like nanovesicles (ELNs) derived from plants are nanoscale vesicles isolated from edible plant sources. Murray (LRM) has garnered growing attention for its dietary value and therapeutic benefits. In this study, a PEG6000-based method was developed to isolate LRM-ELNs.

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  • Researchers developed a CuSe@LYC composite, using lycorine and CuSe nanoparticles, which can generate reactive oxygen species (ROS) when exposed to near-infrared-II (NIR-II) light.
  • Treatment with the composite and NIR-II significantly reduced scar-related markers and induced cell death in hypertrophic scar fibroblasts, showing promise for safe clinical applications in managing scars.
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Cancer has become an important public health problem worldwide, and there is currently a lack of effective treatment and prevention strategies. Natural plant active ingredients have been proven to be a safe and highly promising method for preventing and treating cancer. It has been found that diallyl trisulfide have anticancer effects in multiple types of cancer via inhibiting cancer proliferation, enhancing chemotherapy sensitivity, inducing apoptosis/autophagy, suppressing invasion/migration, regulating microenvironment.

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  • - Accurate measurement of cerebral ascorbic acid (AA) is essential for studying ischemic stroke, but traditional methods face challenges due to proteins in brain tissue interfering with the measurements
  • - The study develops a modified carbon fiber microelectrode (CFE) using a new material, PFC-71, which improves the sensor's performance by reducing protein adsorption and allowing for sensitive detection of AA
  • - The modified CFE shows enhanced capability to measure AA levels accurately in a model of stroke, demonstrating a ratiometric electrochemical method that works even in complex biological environments
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Plants need to fine-tune defense responses to maintain a robust but flexible host barrier to various pathogens. Helix-loop-helix/basic helix-loop-helix (HLH/bHLH) complexes play important roles in fine-tuning plant development. However, the function of these genes in plant immunity and how they are regulated remain obscure.

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  • * The research showed that α-arbutin enhances antioxidant levels and impacts mitochondrial health by increasing specific proteins (SIRT3 and PGC-1α) in both human skin cells and mice exposed to UVA radiation.
  • * Ultimately, α-arbutin offers protection against UVA damage by activating the SIRT3/PGC-1α signaling pathway, reducing skin damage caused by UV exposure.
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Cancer, including gastric cancer, has become a serious disease that jeopardizes public life. Currently, the main treatment methods are surgery, radiation therapy, and chemotherapy. One of the primary causes of death for patients with gastric cancer is drug resistance.

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Current research reports that lactate affects Treg metabolism, although the precise mechanism has only been partially elucidated. In this study, we presented evidence demonstrating that elevated lactate levels enhanced cell proliferation, suppressive capabilities, and oxidative phosphorylation (OXPHOS) in human Tregs. The expression levels of Monocarboxylate Transporters 1/2/4 (MCT1/2/4) regulate intracellular lactate concentration, thereby influencing the varying responses observed in naive Tregs and memory Tregs.

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The airborne fungus Aspergillus fumigatus is a major pathogen that poses a serious health threat to humans by causing aspergillosis. Azole antifungals inhibit sterol 14-demethylase (encoded by cyp51A), an enzyme crucial for fungal cell survival. However, the most common mechanism of azole resistance in A.

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Pneumocandin B (PB) is a lipopeptide produced by the fungus Glarea lozoyensis. The existing challenges with the low-yield and the extended-fermentation cycle emphasize necessity for strain improvement. In this study, we optimized conditions to obtain high-quality protoplasts and screened effective selection markers, leading to the construction of three CRISPR/Cas9 gene editing systems.

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Among the many far-reaching consequences of the potential existence of a magnetic monopole, it induces a topological zero mode in the Dirac equation, which was derived by Jackiw and Rebbi 48 years ago and has been elusive ever since. Here, we show that the monopole and multi-monopole solutions can be constructed in the band theory by gapping the three-dimensional Dirac points in hedgehog mass configurations. We then experimentally demonstrate such a monopole bound state in an optimized Dirac acoustic crystal structurally modulated in full solid angles.

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  • This study investigates the role of ATG7, a protein involved in autophagy, in women with and without polycystic ovary syndrome (PCOS).
  • It found that women with PCOS had significantly lower serum ATG7 levels compared to healthy women, which indicates an increased risk of developing the condition.
  • The research suggests that ATG7 could be a potential biomarker for diagnosing and managing PCOS, especially in combination with HOMA-IR measurements.
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The COVID-19 pandemic introduced an urgent need for rapid and high-throughput testing for SARS-CoV-2. RNA extraction is a major bottleneck for RT-qPCR. We describe a semi-automated, extraction-free RT-qPCR assay for detection of SARS-CoV-2 in nasal swab and saliva samples on a single platform.

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