Calycosin alleviates ovariectomy-induced osteoporosis by promoting BMSCs autophagy via the PI3K/Akt/mTOR pathway.

Calycosin, the main extract from the traditional Chinese medicine (TCM) Astragalus membranaceus, has demonstrated anti-osteoporotic properties in ovariectomized (OVX) mice. However, the specific pathways through which it prevents osteoporosis remain unexplored. This study aimed to investigate the pathways by which calycosin promotes autophagy in bone marrow mesenchymal stem cells (BMSCs) and alleviates ovariectomy-induced osteoporosis.

A Novel 3D-Printing Model Resin with Low Volumetric Shrinkage and High Accuracy.

This study aims to assess and compare the shrinkage, accuracy, and accuracy stability of a novel 3D-printing model resin and eight commercially available 3D-printing model resin materials. The experimental model resin was developed by our 3D-printing proprietary resin technology. Eight commercially available 3D-printing model resins were included for comparison.

Microwave Absorption Properties of Graphite Nanosheet/Carbon Nanofiber Hybrids Prepared by Intercalation Chemical Vapor Deposition.

Carbon-based microwave absorption materials have garnered widespread attention as lightweight and efficient wave absorbers, emerging as a prominent focus in the field of functional materials research. In this work, FeNi nanoparticles, synthesized in situ within graphite interlayers, were employed as catalysts to grow carbon nanofibers in situ via intercalation chemical vapor deposition (CVD). We discovered that amorphous carbon nanofibers (CNFs) can exfoliate and separate highly conductive graphite nanosheets (GNS) from the interlayers.

Association of the various physical activity patterns with low bone mineral density in Americans aged 20-60.

Unlabelled: Through analyzing the data of the NHANES 2007-2020 cycle, this study concluded that high-intensity exercise 1-2 sessions a week can help maintain bone mass, and there is no significant difference from regular exercise more than 3 times a week.

Purpose: This study aims to explore the relationship between the various physical activity(PA) patterns and the risk of low bone mineral density(BMD) in Americans of working age.

Method: A total of 6482 participants aged 20-60 were selected from the National Health and Nutrition Survey (NHANES) conducted from 2007 to 2020.

Advancing the Fight Against Cervical Cancer: The Promise of Therapeutic HPV Vaccines.

Human papillomavirus (HPV) is a major global health issue and is recognized as the leading cause of cervical cancer. While prophylactic vaccination programs have led to substantial reductions in both HPV infection rates and cervical cancer incidence, considerable burdens of HPV-related diseases persist, particularly in developing countries with inadequate vaccine coverage and uptake. The development of therapeutic vaccines for HPV represents an emerging strategy that has the potential to bolster the fight against cervical cancer.

A Simple Nomogram for Predicting the Development of ARDS in Postoperative Patients with Gastrointestinal Perforation: A Single-Center Retrospective Study.

Background: Acute respiratory distress syndrome (ARDS) is a severe form of organ dysfunction and a common postoperative complication. This study aims to develop a predictive model for ARDS in postoperative patients with gastrointestinal perforation to facilitate early detection and effective prevention.

Methods: In this single-center retrospective study, clinical data were collected from postoperative patients with gastrointestinal perforation admitted to the ICU in Hebei Provincial People's Hospital from October 2017 to May 2024.

Mechanical Properties and Degree of Conversion of a Novel 3D-Printing Model Resin.

The aim of this study was to evaluate the mechanical properties and degree of conversion of a novel 3D-printing model resin and compare it to eight commercially available model resins. An experimental resin formulated by our proprietary resin technology along with DentaModel, NextDent 2, KeyModel Ultra, Rodin Model, Die and Model 2, DMR III, LCD Grey, and Grey Resin were used in this study. Parallelepiped specimens (2 × 2 × 25 mm, n = 5) were printed and measured for their flexural strength (FS), flexural modulus (FM), and modulus of resilience (MR) in accordance with ISO-4049.

Unveiling miRNA30b's Role in Suppressing ADAM12 to Combat Triple-Negative Breast Cancer.

Triple-negative breast cancer, a subtype of breast cancer, is characterized by a poor prognosis. Recent studies have shown that miRNA30b acts as an oncogene and is vital for the proliferation of malignancies across various systems. This study aimed to elucidate the impact of miRNA30b on the proliferation, migration, and invasion capabilities of breast cancer cells .

Patterns in coarse root decomposition of woody plants: effects of climate, root quality, mycorrhizal associations and phylogeny.

Coarse roots represent a globally important belowground carbon pool, but the factors controlling coarse root decomposition rates remain poorly understood relative to other plant biomass components. We compiled the most comprehensive dataset of coarse root decomposition data including 148 observations from 60 woody species, and linked coarse root decomposition rates to plant traits, phylogeny and climate to address questions of the dominant controls on coarse root decomposition. We found that decomposition rates increased with mean annual temperature, root nitrogen and phosphorus concentrations.

Performance of urinary C-C motif chemokine ligand 14 and the renal resistive index in predicting persistent AKI.

Objectives: The purpose of this study was to evaluate the performance of urinary C-C motif chemokine ligand 14 (CCL14) and the renal resistive index (RI) in predicting persistent AKI in unselected critically ill patients.

Methods: This prospective observational study was conducted in a tertiary hospital's general intensive care unit (ICU). Consecutive adults who were admitted to the ICU were enrolled, with a primary endpoint of AKI lasting 48 h or longer.

Hierarchical Interfacial Construction by Grafting Cellulose Nanocrystals onto Carbon Fiber for Improving the Mechanical Performance of Epoxy Composites.

Carbon fiber-reinforced composites have been widely used in the aerospace industry because of their superior comprehensive performance, including high strength, low density, fatigue resistance, long service life, etc. The interface between the fiber reinforcement and the matrix is one of the key factors that determines the performance of the composites. The construction of covalent bonding connections between the components has proven to be an effective strategy for improving the interfacial bonding strength but always reduces the toughness.

CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis.

Circulating tumor cells (CTCs) are cancer cells that detach from the primary tumor and enter the bloodstream, where they can seed new metastatic lesions in distant organs. CTCs are often associated with white blood cells (WBCs), especially neutrophils, the most abundant and versatile immune cells in the blood. Neutrophils can interact with CTCs through various mechanisms, such as cell-cell adhesion, cytokine secretion, protease release, and neutrophil extracellular traps (NETs) formation.

Mahuang Fuzi Xixin decoction: A potent analgesic for neuropathic pain targeting the NMDAR2B/CaMKIIα/ERK/CREB pathway.

Neuropathic pain (NeP) is a condition charactesized by nervous system injury or dysfunction that affects a significant portion of the population. Current treatments are ineffective, highlighting the need for novel therapeutic approaches. Mahuang Fuzi Xixin decoction (MFXD) has shown promise for treating pain conditions in clinical practice; however, its potential against NeP and the underlying mechanisms remain unclear.

A Newly Formulated Vinyl Polysiloxane Impression Material with Improved Mechanical Properties.

Aim: To evaluate the mechanical properties of a newly formulated vinyl polysiloxane (VPS) impression material.

Materials And Methods: Experimental, Capture (S&C Polymer), Express, Imprint 3 and Imprint 4 (3M ESPE), Start VPS (Danville), Honigum (DMG), Virtual (Ivoclar Vivadent), Elite HD+ (Zhermack) were evaluated for tear strength, tensile strength, and elongation at break. Un-nicked specimens with a 90° angle on one side (type C) for tear strength were prepared and tested according to ASTM-D624.

Smart Microneedle Arrays Integrating Cell-Free Therapy and Nanocatalysis to Treat Liver Fibrosis.

Liver fibrosis is a chronic pathological condition lacking specific clinical treatments. Stem cells, with notable potential in regenerative medicine, offer promise in treating liver fibrosis. However, stem cell therapy is hindered by potential immunological rejection, carcinogenesis risk, efficacy variation, and high cost.

A robust, eco-friendly, and biodegradable cellulose nanofiber composite film for highly effective formaldehyde removal at room temperature.

Formaldehyde (HCHO) poses a significant threat as a common indoor air pollutant, leading to various health issues. However, effectively addressing HCHO removal at room temperature remains a considerable challenge. This paper presents the preparation of a robust, eco-friendly, and biodegradable composite cellulose nanofiber film, incorporating CeO-Ag@MnO catalysts and TEMPO-oxidized cellulose nanofiber (TOCNF), for high-efficiency HCHO removal at room temperature.

Preparation of a self-matting, anti-fingerprint and skin-tactile wood coating via biomimetic self-wrinkling patterns.

Inspired by natural wrinkled surfaces, artificial surfaces with biomimetic wrinkled structures have been widely used to improve optical properties, wettability, and antibacterial properties. However, the preparation of wrinkled structures has the disadvantages of long-time consumption and complex processes. Herein, we prepared a self-wrinkling polyurethane-acrylate (PUA) wood coating via biomimetic self-wrinkling patterns by using a light-emitting diode (LED)/excimer/mercury lamp curing system, which was capable of self-matting, anti-fingerprint and skin-tactile performance.

Tumor Stiffness Measurement at Multifrequency MR Elastography to Predict Lymphovascular Space Invasion in Endometrial Cancer.

Background Pathologic lymphovascular space invasion (LVSI) is associated with poor outcome in endometrial cancer. Its relationship with tumor stiffness, which can be measured with use of MR elastography, has not been extensively explored. Purpose To assess whether MR elastography-based mechanical characteristics can aid in the noninvasive prediction of LVSI in patients with endometrial cancer.

Cardiopulmonary Coupling Spectrogram as an Ambulatory Method for Assessing Sleep Disorders in Patients With Autoimmune Encephalitis.

Background And Objectives: Sleep disorders are a common and important clinical feature in patients with autoimmune encephalitis (AE); however, they are poorly understood. We aimed to evaluate whether cardiopulmonary coupling (CPC), an electrocardiogram-based portable sleep monitoring technology, can be used to assess sleep disorders in patients with AE.

Methods: Patients fulfilling the diagnostic criteria of AE were age- and sex-matched with recruited healthy control subjects.

Kurarinone, a flavonoid from Radix Sophorae Flavescentis, inhibits RANKL-induced osteoclastogenesis in mouse bone marrow-derived monocyte/macrophages.

Inflammation-induced osteoclast proliferation is a crucial contributor to impaired bone metabolism. Kurarinone (KR), a flavonoid extracted from the Radix Sophorae Flavescentis, exhibits notable anti-inflammatory properties. Nevertheless, the precise influence of KR on osteoclast formation remains unclear.

Experimental and Simulation Investigation on Fatigue Performance of H13 Steel Tools in Friction Stir Welding of Aluminum Alloys.

As the central component in friction stir welding, the design and manufacture of welding tools for aluminum alloys have garnered substantial attention. However, the understanding of tool reliability during the welding process, especially in terms of fatigue performance, remains unclear. This paper focuses on the welding of AA2219-T4 as a case study to elucidate the predominant failure mode of the tool during the friction stir welding (FSW) of aluminum alloys.