Publications by authors named "Ling Ling Wang"

Objective: To evaluate the clinical therapeutic effect of depression treated by acupuncture and electroacupuncture combined with western medicine.

Methods: Seventy-five patients were randomly divided into 3 groups. In control group, 30 cases were treated by SSRI with oral administration; in observation group 1, 25 cases were treated by acupuncture therapy combined with SSRI, and Shenting (GV 24), Baihui (GV 20), Dazhui (GV 14), Shendao (GV 11) and Zhiyang (GV 9) etc.

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Purpose: To observe the effects of endothelial progenitor cells (EPCs) on bone formation of tissue engineered bone in dogs.

Methods: Bone marrow stromal cells (BMSCs) and EPCs were derived from dog bone marrow and cultured in different medium in vitro. They were seeded on demineralized bone matrix (DBM) to build tissue engineered bone, then the construct was implanted into the fasciae of latissimus dorsi muscle, the degree of bone formation was analyzed with imaging and histological methods at different time points.

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Four characteristics and five major superiorities of traditional Chinese acupuncture was expounded in this article. The four characteristics are (1) theoretical characteristic which focuses on meridians, acupoints, circulation of qi and blood; (2) effect mechanism of disease prevention and treatment based on external stimulation and internal regulation; (3) clinical diagnosis with the combination of differentiation of syndromes according to meridians and collaterals, zang-fu organs, eight principles and diagnosis based on acupoints; (4) technical characteristic of adoption of unique apparatus and special manipulations. The five superiorities are (1) diagnosis: simple, rapid and accurate; (2) technique: easy to study and manipulate; (3) therapeutic effect: quick and obvious effect, extensive indications; (4) safety: non-toxic and less side-effects; (5) cost: comparatively cheap.

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Treatment regimens of secondary hemophagocytic lymphohistiocytosis (sHLH) are complicated and individualized. CHOP regimen is well known for the treatment of adult sHLH, but it was not so effective for the 56-year-old male patient in our study. Splenomegaly, one of clinical manifestations of HLH, has urged us to investigate the role of splenectomy in HLH patients.

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Objective: To compare the therapeutic effect differences of chronic functional constipation treated with the combined therapy of grain-shaped moxibustion and acupuncture and simple acupuncture therapy.

Methods: One hundred cases of constipation were randomly divided into an acupuncture and moxibustion group and an acupuncture group by fifty-fifty. Both groups were treated by acupuncture therapy with acupoints of two groups alternatively.

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Objective: To explore the relationship between the effect of electroacupuncture (EA) and EA of different layer tissues of the acupoint area and different acupoints in upregulating mean arterial pressure (MAP) and heart rate (HR) in hypotension plus bradycardia rats.

Methods: A total of 200 SD rats were used in the present study. Bradycardia plus hypotension model was established by intravenous injection of 0.

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Based on the finite-difference time-domain method, we investigate the transmission resonances of compound metallic gratings with two subwavelength slits filled with different dielectrics inside each period in the visible and near infrared regions. The results show that the transmission spectrum is almost a compound of that of two corresponding simple gratings expect for the transmission feature at a certain resonant wavelength, where the Fabry-Pérot (FP)-like phenomena have been found both inside the two slits, but the orders of the FP-like modes are different. If the order of the FP-like mode inside one slit is one bigger than inside the other, the intensity of the transmission will be significantly weakened.

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To illustrate the theoretical basis of warming and dredging function of moxibustion from the treatment features, indications and effects. The causation of moxibustion is warming stimulation, and the mechanism of action is dredging meridians and collaterals. In a word, promoting the dredging function by warming is the main mechanism of therapeutic effect of moxibustion.

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Objective: To probe into the relevance between the parameters of mild moxibustion (persistent time, interval time, treatment session) and the efficacy, as well as the optimum treatment program of mild moxibustion in hypercholesterolemia.

Methods: The patients with hypercholesterolemia were selected as the observation objects. Mild moxibustion was applied to Shenque (CV 8) and Zusanli (ST 36).

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This study was aimed to investigate the therapeutic efficacy of HLH-2004 chemotherapy in patients with secondary hemophagocytic lymphohistiocytosis (sHLH). 10 cases of sHLH treated with HLH-2004 regimen at our department were analyzed retrospectively. The results showed that 7 patients had clinical response to HLH-2004 regimen, while other 3 patients had no clinical response.

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Clinical and experimental studies show that the onset of effect of acupuncture on depression is more rapid than selective serotonin reuptake inhibitors, a class of antidepressants. Acupuncture treatment is characterized by controlling anxiety and gastrointestinal discomfort. The onset time of acupuncture treatment for various pains is a week or so, which is the same as the rapid onset time of antidepressant effect of acupuncture, and the main pathway of acupuncture analgesia is through endogenous opioid system.

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Calcyclin-binding protein (CacyBP) is a tumor suppressor in gastric and renal cell carcinoma, but an oncogene in pancreatic cancer. However, the function of CacyBP in breast cancer has not been well elucidated. In this study, we explored the clinical relevance of CacyBP and investigated the relationship between CacyBP and COX-2 in breast cancer.

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Postoperative cognitive dysfunction (POCD) is characterized by the progressive deterioration of intellectual/cognitive function following surgery. It has been suggested that the senile brain, which characteristically expresses higher levels of central proinflammatory cytokines, interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α, is more susceptible to additional insult following surgery. The authors of this study investigated the expression of central cytokines IL-1β, IL-6 and TNF-α and hippocampal glial cell activation in aged and adult rats following partial hepatectomy.

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Objective: To observe the effect of electroacupuncture (EA) on the profiles of hippocampal whole-genome expression in depression rats so as to study its underlying mechanism in relieving depression.

Methods: Thirty male SD rats were randomized into normal, model and EA groups (n = 10/group). Depression model was established by chronic unpredictable stress stimulation (forced ice-water swimming, electric shock, tail-clamping, etc.

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Based on the serum pharmacochemistry technique and high-performance liquid chromatography/diode-array detection (HPLC/DAD) coupled with electrospray tandem mass spectrometry (HPLC/ESI-MS/MS), a method for screening and analysis of the multiple absorbed bioactive components and metabolites of Jitai tablets (JTT) in orally dosed rat plasma was developed. Plasma was treated by methanol precipitation prior to liquid chromatography, and the separation was carried out on a Symmetry C(18) column, with a linear gradient (0.1% formic acid/water/acetonitrile).

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We propose a compound metallic grating with perpendicular cuts in each slit and investigate its optical transmission property theoretically. The odd and even waveguide modes exhibit different behaviors when the cuts are set asymmetrically in the slits. Particularly, it is shown that the transmission dips of transmission spectrum for this compound periodic structure can be realized alternately by shifting the position of cuts in the slit.

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Objective: To investigate the status of Notch signaling pathway in small cell lung cancer (SCLC).

Methods: Expression plasmids of pEFBOS-NIC-MYC and pEFBOS-neo were transfected into NCI-H446 cells. Stably transfected cell lines were selected and their growth rates were examined by MTT method.

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Objective: To discuss the effect of acupuncture for treatment of chronic functional constipation (CFC).

Methods: Ninety cases were treated with acupuncture. The following two groups of acupoints were used alternatively once every other day.

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The authors set up two groups, the treatment group and the control group, to observe the influence of electro-acupuncture on the side effects produced by fluoxetine in the treatment of depression. The result showed that electro-acupuncture had a certain action in reducing the side effects of fluoxetine and it is more effective along with the prolonging of the administration duration.

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Through combing the academic development of acupuncture in recent ten years, objectively reflects the real development status of acupuncture subject on these aspects sucl as basis, clinic, equipment, teaching and standardization, etc., shows the scientific and technological achievements and the highlights of the acupuncture academic development, analyzes the bottleneck and dilemma of the acupuncture academic development. It is indicated that there are several problems existed in acupuncture researche at present, such as the scale and the input of the acupuncture theory research are not enough, the basic research and clinical application is disjointed, the correlation between the acupoints and viscera need more systematic and further researches, the design level of clinical research on acupoints' main indications should be improved.

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Herein, we prepared water-soluble fluorescent carbon dots with diameter about 1.5 nm from cheap commercial lampblack. These fluorescent carbon nanoparticles are stable toward photobleaching and stable in water for more than half a year without fluorescence decrease.

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Objective: To investigate the expression of CD147 and E-cadherin in gastric carcinoma and their correlation with clinicopathological features.

Methods: The expression of CD147 and E-cadherin in gastric cancer tissue chip (TC) was detected by in situ hybridization (ISH) and immunohistochemistry in 220 cases of gastric carcinoma and 31 cases with normal gastric mucosa.

Results: The expression rates of CD147 mRNA, E-cadherin mRNA and E-cadherin protein were 50.

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Objective: To observe the therapeutic effect of digital acupoint pressure for treatment of the nerve root type of cervical spondylosis.

Methods: Four hundred cases were randomly divided into a digital acupoint pressure group (DAP group) and a medicine group, 200 cases in each group. Acupoints of Quepen (ST 12), Jianjing (GB 21) and Tianzong (ST 11) etc.

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