Publications by authors named "Ling Ling Li"

We present a case of rosacea recurrence in a 37-year-old woman associated with the intake of compound vitamin tablets during the preconception period, with a Naranjo score of 7. These tablets, commonly used for nutritional supplementation to prevent anemia, contain a variety of vitamins, minerals, and trace elements. Despite their widespread use, reports of such supplements causing rosacea recurrence are rare.

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Eupalinolide B (EB), a primary bioactive compound isolated from Eupatorium lindleyanum DC., has exhibited various pharmacological properties, such as antitumor, anti-inflammatory, and notably, neuroprotective effects in neurodegenerative diseases. However, the in-depth studies on the antidepressant potential of EB and its underlying mechanisms are still lacking.

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Background: Aquaporin 1 (AQP1) is a promising target for regulating fibroblast-like synoviocyte (FLS) behaviors in rheumatoid arthritis (RA). Bacopaside I (BSI), the main active compound of the herbal medicine Bacopa monnieri with anti-RA effects, inhibits tumor cell growth by blocking AQP1, but its potential use in RA is unclear.

Purpose: To address BSI's anti-RA effects and elucidate its underlying mechanisms.

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Background: Rheumatoid arthritis (RA) is an inflammatory disease of the joints mediated by immune cells. As an immune-related mode of cell death, pyroptosis has yet to be fully understood in RA. This research identified novel pyroptosis-related markers in RA and confirmed its functional significance in RA.

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The excessive proliferation of fibroblast-like synoviocytes (FLS) leads to synovial hyperplasia, a key pathological hallmark of rheumatoid arthritis (RA). Eupalinolide B (EB), a sesquiterpene lactone of Eupatorium lindleyanum DC., has anti-inflammatory effects and anti-proliferative activity in tumor cells.

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Objective: Fibroblast-like synoviocytes (FLS) are key players in rheumatoid arthritis (RA) by resisting apoptosis via increased autophagy. Elevated synovial aquaporin 1 (AQP1) affects RA FLS behaviors, but its relationship with FLS autophagy is unclear. We aim to clarify that silencing AQP1 inhibits autophagy to exert its anti-RA effects.

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Article Synopsis
  • - The study investigates the relationship between nutritional markers and the risk of Parkinson's disease (PD) and Alzheimer's disease (AD) among 424 PD patients, 314 AD patients, and 388 healthy controls.
  • - Key findings reveal that higher levels of apolipoprotein B (ApoB), low-density lipoprotein (LDL), and total cholesterol (TC) are linked to a lower risk of PD, while homocysteine (HCY) levels increase the risk; for AD, ApoA1 shows protective effects, while HCY acts as a risk factor.
  • - The results highlight the significance of lipid and one-carbon metabolism in the development of PD and AD, emphasizing the nutritional aspects that could influence these
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This study aimed to perform exhaustive bioinformatic analysis by using GSE29221 micro-array maps obtained from healthy controls and Type 2 Diabetes (T2DM) patients. Raw data are downloaded from the Gene Expression Omnibus database and processed by the limma package in R software to identify Differentially Expressed Genes (DEGs). Gene ontology functional analysis and Kyoto Gene Encyclopedia and Genome Pathway analysis are performed to determine the biological functions and pathways of DEGs.

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Objective: To analyze the factors affecting overall survival (OS) of adult patients with core-binding factor acute myeloid leukemia (CBF-AML) and establish a prediction model.

Methods: A total of 216 newly diagnosed patients with CBF-AML in the First Affiliated Hospital of Zhengzhou University from May 2015 to July 2021 were retrospectively analyzed. The 216 CBF-AML patients were divided into the training and the validation cohort at 7∶3 ratio.

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Bioaugmentation techniques still show drawbacks in the cleanup of total petroleum hydrocarbons (TPHs) from petroleum-contaminated site soil. Herein, this study explored high-performance immobilized bacterial pellets (IBPs) embed Microbacterium oxydans with a high degrading capacity, and developed a controlled-release oxygen composite (CROC) that allows the efficient, long-term release of oxygen. Tests with four different microcosm incubations were performed to assess the effects of IBPs and CROC on the removal of TPHs from petroleum-contaminated site soil.

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  • The study investigates the role of circUBE2D2 in promoting ovarian cancer progression by upregulating HMGB1 and inhibiting miR-885-5p.
  • Researchers used various assays to assess cell functions, confirming that circUBE2D2 acts as a sponge for miR-885-5p, which directly targets HMGB1.
  • Findings suggest that targeting circUBE2D2 may offer a novel treatment approach for ovarian cancer by reducing tumor growth and altering cell behaviors.
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Background: Bronchiectasis has high rates of hemoptysis and recurrent hemoptysis, which is inconsistent among various etiologies. Idiopathic bronchiectasis and post-tuberculous bronchiectasis are two important etiologies in China, but the differences in clinical features and risk factors of recurrent hemoptysis have not been elucidated.

Methods: Patients hospitalized for idiopathic bronchiectasis or post-tuberculosis bronchiectasis were included.

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Photothermal therapy is favored by cancer researchers due to its advantages such as controllable initiation, direct killing and immune promotion. However, the low enrichment efficiency of photosensitizer in tumor site and the limited effect of single use limits the further development of photothermal therapy. Herein, a photo-responsive multifunctional nanosystem was designed for cancer therapy, in which myeloid-derived suppressor cell (MDSC) membrane vesicle encapsulated decitabine-loaded black phosphorous (BP) nanosheets (BP@ Decitabine @MDSCs, named BDM).

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  • The study aimed to assess the impact of noninvasive brain stimulation (NIBS) on enhancing upper extremity motor function and daily activities in stroke patients, while also evaluating various stimulation protocols for better clinical recommendations.
  • A systematic review of randomized controlled trials (RCTs) from several databases was conducted, resulting in the inclusion of 94 trials with 5546 patients, which demonstrated significant improvements in various motor function assessments, like the Fugl-Meyer assessment and MBI scores.
  • The network meta-analysis ranked interventions for improving FMA scores, showing that anodal-transcranial direct current stimulation (tDCS) was the most effective, followed closely by cathodal-tDCS, providing a clearer
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Objective: We aimed to investigate the value of contrast-enhanced ultrasound (CEUS) in the preoperative prediction of the histological grades and molecular subtypes of breast cancer.

Methods: A total of 183 patients with pathologically confirmed breast cancer were included. Contrast enhancement patterns and quantitative parameters were compared in different groups.

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The Purpose of the present study was to quantify the responses of ten cell lines (HeLa, HepG2, HEK293, MDA-MB-231, A498, A549, A357, 3 T3, BALB-C3 T3, and NIH-3 T3) to spent fluid catalytic cracking catalysts (SFCCCs) from different petroleum refineries, and relate these responses to metal concentrations of SFCCC leachates (SFCCCLs). Cytotoxicity of SFCCCs were significantly different depending on cell lines. A357 and 3 T3 cell were the most sensitive, and A498 and HeLa cells were the least sensitive.

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The present study evaluated the potential of endogenous enzymes and probiotics in transforming bioactive metabolites to reduce the purgative effect and improve the functional activity of Cassiae Semen and verified and revealed the biotransformation effect of endogenous enzymes. Although probiotics, especially , exerted the transformation effect, the endogenous enzymes proved to be more effective in transforming the components of Cassiae Semen. After biotransformation by endogenous enzymes for 12 h, the levels of six anthraquinones in Cassiae Semen increased by at least 2.

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Introduction: In light of the significant impact that teachers have on education quality and student growth, their mental health warrants special attention. With the increasing popularity of Information and Communication Technology (ICT) and the rise of online teaching during the pandemic, teachers have become a group prone to developing problematic smartphone use (PSU). Psychological need thwarting (PNT) has been shown to be closely related to PSU, psychological distress, and perceived administrative support.

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Previous studies have suggested that ischemic stroke can result in white matter fiber injury and modifications in the structural brain network. However, the relationship with balance function scores remains insufficiently explored. Therefore, this study aims to explore the alterations in the microstructural properties of brain white matter and the topological characteristics of the structural brain network in postischemic stroke patients and their potential correlations with balance function.

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In this study, an adapted bioleaching strain of Acidithiobacillus caldus UVS10 was successfully developed. Batch tests and tests in bioreactor were conducted to evaluate the metals bioleaching performance of A. caldus UVS10 to spent FCC catalyst (SFCCC).

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  • The study aimed to assess the effectiveness of measuring PCT, CRP, and FIB levels in distinguishing between severe bacterial and viral pneumonia.
  • A cohort of 100 patients with severe pneumonia, consisting of equal groups for viral and bacterial infections, was analyzed alongside a healthy control group, focusing on the differences in biomarker levels.
  • Results showed that combined detection of PCT, CRP, and FIB provided higher sensitivity and specificity for diagnosing bacterial versus viral pneumonia compared to single tests, indicating its potential for better clinical diagnosis.
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Bronchoscopic lung volume reduction (BLVR) is a feasible, safe, effective and minimally invasive technique to significantly improve the quality of life of advanced severe chronic obstructive pulmonary disease (COPD). In this study, three-dimensional computed tomography (3D-CT) automatic analysis software combined with pulmonary function test (PFT) was used to retrospectively evaluate the postoperative efficacy of BLVR patients. The purpose is to evaluate the improvement of lung function of local lung tissue after operation, maximize the benefits of patients, and facilitate BLVR in the treatment of patients with advanced COPD.

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Background: In recognizing the need for a reliable and valid instrument to assess psychological distress among children and adolescents, the present study translated the newly developed Depression Anxiety Stress Scale for Youth (DASS-Y) into Chinese, while also comparing its psychometric properties with those of the well-established DASS-21 within a primary and middle school demographic.

Methods: Utilizing a combination of convenience sampling and purposive sampling, a cohort comprising 1,507 primary and 1,131 middle school students was recruited. Rasch analysis, confirmatory factor analysis (CFA), and structural equation modeling (SEM) were used in the data analysis.

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  • Alternation of generations in plants influences natural selection in both the gametophyte and sporophyte phases, potentially leading to varied evolutionary rates for specific genes.
  • The study examines how antagonistic and synergistic selections between these generations affect the ratio of nonsynonymous to synonymous divergence (Ka/Ks), revealing different outcomes based on the type of selection.
  • Factors like selfing, genetic drift, and gene flow also influence the effectiveness of selection and the genetic diversity observed, complicating the understanding of natural selection in plants.
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  • The study evaluated the effectiveness and safety of probiotics in treating urticaria using randomized controlled trial data published before May 2019.
  • A total of nine studies were analyzed, revealing that single probiotics showed a significant therapeutic effect compared to placebo and antihistamines, while multiple probiotics did not demonstrate a statistically significant improvement.
  • The incidence of side effects was comparable between the probiotic and control groups, indicating that probiotics are generally safe for use in urticaria treatment.
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