Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Hyperlipidemia is a major risk factor for hypertension, coronary heart disease, diabetes and stroke, triggering an intensified research efforts into its prevention and treatment. Tetrahydroberberrubine (THBru) is a derivative of berberine (BBR) that has been shown to have higher bioavailability and lower toxicity compared to its parent compound. However, its impact on hyperlipidemia has not been fully explored.

Effect of catalase on CPC production during fermentation of Acremonium chrysogenum.

Cephalosporin C (CPC) is a critical raw material for cephalosporin antibiotics produced by Acremonium chrysogenum. During fermentation, the oxygen supply is a crucial factor limiting the efficient biosynthesis of CPC. This study demonstrated that the addition of exogenous surfactants significantly increased the dissolved oxygen (DO) level, extracellular catalase content, and final CPC titer.

Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation.

Organ transplantation is the last-resort option to treat organ failure. However, less than 10% of patients benefit from this only option due to lack of major histocompatibility complex (MHC)-matched donor organs and 25%-80% of donated organs could not find MHC-matched recipients. T cell allorecognition is the principal mechanism for allogeneic graft rejection.

Atorvastatin Attenuates Endothelial Cell Injury in Atherosclerosis Through Inhibiting ACSL4-Mediated Ferroptosis.

This study is aimed at investigating the effects of atorvastatin (ATV) on endothelial cell injury in atherosclerosis (AS) through inhibiting acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis. Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL) to establish an in vitro model of AS. The cell viability, lactate dehydrogenase (LDH) release, apoptosis, and expression levels of apoptotic proteins were assessed.

Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.

Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China.

Quantitative electroencephalography predicts postoperative delirium in adult cardiac surgical patients from a prospective observational study.

The diagnostic and prognostic value of quantitative electroencephalogram (qEEG) in the the onset of postoperative delirium (POD) remains an area of inquiry. We aim to determine whether qEEG could assist in the diagnosis of early POD in cardiac surgery patients. We prospectively studied a cohort of cardiac surgery patients undergoing qEEG for evaluation of altered mental status.

Determination and Prediction of Available Energy in 13 Cereal Feed Ingredients for Growing Pigs.

This study was conducted to develop equations to predict the digestible (DE) and metabolizable energy (ME) for growing pigs by using the chemical compositions of five corn, two wheat and six rice samples. A total of 13 castrated boars were chosen and fed 13 diets formulated with different cereal feed ingredients according to a 13 × 6 Youden square design. The DE and ME contents, the ratio of ME to DE, and the nutrient digestibility among the 13 cereal feed ingredients were different ( < 0.

Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study.

Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.

Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).

A Recombinant Human Collagen and RADA-16 Fusion Protein Promotes Hemostasis and Rapid Wound Healing.

In this study, we designed a fusion protein, rhCR, by combining human collagen with the self-assembling peptide RADA-16 using genetic engineering technology. The rhCR protein was successfully expressed in . The rhCR can self-assemble into a three-dimensional nanofiber network under physiological conditions.

[Determination of 12 halogenated organic pollutants in edible fish by ultra performance liquid chromatography-high resolution mass spectrometry combined with ultrasound-assisted extraction and gel permeation chromatography purification].

Halogenated organic pollutants (HOPs) have attracted considerable attention owing to their persistence, bioaccumulation, and toxicity. The development of methods to detect HOPs in fish is challenging owing to the compositional complexity of fish matrices, which contain high levels of lipids and relatively low concentrations of HOPs. In addition, the lipophilicity of most HOPs renders their extraction difficult.

Sex-specific effects of triphenyltin on gut microbiota and intergenerational effects in marine medaka (Oryzias melastigma).

In this study, a mixed model was applied to the marine medaka to investigate the intergenerational effects of parental exposure to Triphenyltin (TPT) and the subsequent perturbations in parental gut microbiota on the gut microbiota of offspring. In addition, "microgenderome" has been focused on elucidating the different responses of males and females to environmental stress. The results indicated that TPT exhibited androgenic effects and long-term toxicological consequences, influencing the internal steroid hormone levels of the offspring and leading to their abnormal growth and development.

Baihu Jia Renshen Decoction may improve skeletal muscle and adipose tissue functions of type I diabetic rats by affecting pancreatic β-cell function.

Background: Baihu Jia Renshen Decoction (BJRD) is used for diabetes mellitus (DM) management in clinics.

Objective: To elucidate the potential mechanism of BJRD in treating type 1 DM (T1DM).

Methods: T1DM models were established via intraperitoneal injection of streptozotocin (STZ).

Biotransport and toxic effects of micro- and nanoplastics in fish model and their potential risk to humans: A review.

The growing body of scientific evidence suggests that micro- and nanoplastics (MPs/NPs) pose a significant threat to aquatic ecosystems and human health. These particles can enter organisms through ingestion, inhalation, dermal contact, and trophic transfer. Exposure can directly affect multiple organs and systems (respiratory, digestive, neurological, reproductive, urinary, cardiovascular) and activate extensive intracellular signaling, inducing cytotoxicity involving mechanisms such as membrane disruption, extracellular polymer degradation, reactive oxygen species (ROS) production, DNA damage, cellular pore blockage, lysosomal instability, and mitochondrial depolarization.

High-intensity focused ultrasound (HIFU) assisted by a rectal Foley catheter for the treatment of recurrent mucinous ovarian cancer: a case report and literature review.

​Mucinous ovarian cancer (MOC) is characterized by high malignancy, poor prognosis and a high recurrence rate. Surgical adjuvant chemotherapy is the main treatment for MOC. The recurrence rate of advanced mucinous ovarian cancer following surgery is significantly high, with limited efficacious treatment options available.

Perceptions, beliefs, and anticipations regarding living wills among Master's degree nursing students in China: an exploratory qualitative study.

Background: Steeped in cultural heritage, the Chinese traditionally equate death with misfortune. This deeply rooted belief has led to a low rate of living will signings and poses challenges for implementing death education. Master's degree nursing students are instrumental in facilitating and promoting the adoption of living wills, leveraging their specialized knowledge in providing compassionate care.

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing.

Old age is associated with a decline in cognitive function and an increase in neurodegenerative disease risk. Brain ageing is complex and is accompanied by many cellular changes. Furthermore, the influence that aged cells have on neighbouring cells and how this contributes to tissue decline is unknown.

Effects of Extrusion on the Available Energy and Nutrient Digestibility of Soybean Meal and Its Application in Weaned Piglets.

Experiments were conducted to investigate the effects of extrusion devices on the available energy and nutrient digestibility of soybean meal (SBM), and further to investigate the impact of different levels of extruded SBM on the growth performance and nutrient digestibility of weaned piglets. In Exp. 1, eighteen crossbreed growing pigs with an initial body weight (BW) of 32.

An Additive-Fabricated Biphasic Scaffold for Procedurally Promoting Bone Regeneration via Antioxidant and Osteogenesis.

The repair process of bone tissue includes the early inflammatory response period and the late tissue repair period. It has been widely approved to be beneficial to the repair of bone injury by procedurally inhibiting the inflammatory response in the early stage and promoting bone regeneration in the late stage. In this study, the nano-hydroxyapatite/Poly(glycolide-co-caprolactone) (n-HA/PGCL) scaffold loaded with icariin was fabricated by fused deposition modeling technique, and the quercetin-loaded GelMA was further filled into the scaffold pores via light-curing methods to form a biphasic scaffold loaded with dual molecules (PHI + GQ scaffold).

Chemical Upcycling of Thermoplastics Towards Thermosets Based on Dynamic Dimethylglyoxime-Urethane Moiety.

Huge annual consumption of thermoplastics results in the generation of large amounts of waste after their service life. Currently, the most popular recycling method based on mechanically melt-reprocessing deteriorates the material performance and is economically unattractive, which makes it unviable to be implemented in large scale. Herein, we present a chemical upcycling strategy that can transform dimethylglyoxime-urethane based thermoplastic waste into thermoset product with superior mechanical properties and higher economic values than the initial one.

Flexible Phase-Change Films with Exceptional Water and Temperature Resistance for Smart Personal Thermal Protection.

Personal thermal protection is crucial in extreme temperature environments, and the rising global temperatures present significant challenges in managing heat stress for individuals. Phase-change materials (PCMs) can absorb or release heat during phase transition to maintain a constant temperature, thus making them ideal innovative thermal protection materials. However, it is currently a bottleneck issue for using PCMs in wearable thermal protection systems due to a balance between the mechanical properties, latent heat, temperature resistance, and rapid response on demand.

Physiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF.

Background: Prone positioning (PP) improves oxygenation in awake patients with acute hypoxemic respiratory failure (AHRF). However, the underlying mechanisms remain unclear in patients with diverse lung morphology. We aimed to determine the short-term effects of awake prone positioning (APP) in AHRF patients with focal and non-focal lung morphology.

SPTLC2 drives an EGFR-FAK-HBEGF signaling axis to promote ovarian cancer progression.

The epidermal growth factor receptor (EGFR) signaling pathway is frequently associated with ovarian cancer (OC) progression. However, inhibition of EGFR signaling in OC patients achieved limited therapeutic effects, highlighting the need to define the mechanism of EGFR deregulation in OC development. Herein we showed that serine palmitoyltransferase long chain base subunit 2 (SPTLC2) acts as a positive regulator in the EGFR signaling pathway in OC.

Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs: A WEB prediction approach.

A new round of monkeypox virus has emerged in the United Kingdom since July 2022 and rapidly swept the world. Currently, despite numerous research groups are studying this virus and seeking effective treatments, the information on the open reading frame, inhibitors, and potential targets of monkeypox has not been updated in time, and the comprehension of monkeypox target ligand interactions remains a key challenge. Here, we first summarized and improved the open reading frame information of monkeypox, constructed the monkeypox inhibitor library and potential targets library by database research as well as literature search, combined with advanced protein modeling technologies (Sequence-based and AI algorithms-based homology modeling).