Two-year outcome of phacogoniotomy for advanced primary angle-closure glaucoma with cataracts: a multicentre study.

Purpose: To report the 2-year effective and safety profile of integrated phacoemulsification with intraocular lens implantation (PEI), goniosynechialysis (GSL) and 120° goniotomy (GT) in advanced primary angle-closure glaucoma (PACG) and cataracts.

Design: Multicentre prospective study.

Methods: 201 eyes of 196 patients who received combined PEI+GSL+ GT were assessed at baseline and re-evaluated at days 1, 7, and at 1, 3, 6, 12 and 24 months postsurgery.

Integrated physiological characterisation and transcriptomics reveals drought tolerance differences between two cultivars of A. sinensis at seedling stage.

Background: Drought can adversely affect the growth and development of Angelica sinensis (Oliv.) Diels seedlings. M1 and M2 are two cultivars of A.

Multidimensional comparative analysis of wild and cultivated based on electronic intelligent sensory technology and chemical composition.

, is a renowned traditional Chinese medicine, has been widely utilized in various pharmaceutical applications. The increasing demand for this material has led to the widespread cultivation of the plant. However, the differences in chemical constituents between wild and cultivated remain unclear.

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research.

Shotgun metagenomics has become a pivotal technology in microbiome research, enabling in-depth analysis of microbial communities at both the high-resolution taxonomic and functional levels. This approach provides valuable insights of microbial diversity, interactions, and their roles in health and disease. However, the complexity of data processing and the need for reproducibility pose significant challenges to researchers.

An mRNA vaccine encoding proteasome-targeted antigen enhances CD8 T cell immunity.

The efficient induction of antigen-specific CD8 T cell activation is crucial in the development of mRNA tumor vaccines. Endogenous antigens are primarily degraded through the ubiquitin-proteasome system, followed by antigen presentation via major histocompatibility complex class I (MHC-I) molecules, leading to the activation of CD8 T cells. Therefore, in this study, a novel mRNA vaccine was developed by fusing the mRNA sequence encoding the antigen with a proteasome-targeting peptide (PTP), aiming to enhance proteasomal targeting of the antigen and facilitate its degradation through the ubiquitin-proteasome system, thereby inducing a stronger CD8 T cell immune response.

Palladium-Catalyzed Intermolecular 1,3-Dienylation of Propargyl Esters Involving the Insertion of SO.

A palladium-catalyzed three-component 1,3-dienylation of propargylic esters with DABSO and aryl iodides has been developed. This novel reductive cross-coupling reaction produces 2-sufonylated 1,3-dienes as single products in the presence of reductive metal Mn with high regio- and chemoselectivities. Control experiments demonstrated that the transformation may undergo a radical process.

Transcriptomic and metabolomic study of the biosynthetic pathways of bioactive components in Amomum tsaoko fruits.

Amomum tsaoko is a significant medicinal and edible plant with documented efficacy in the treatment of various diseases. Additionally, it is a crucial food additive and spice. 1,8-cineole and curcumin are the main bioactive compounds of A.

Exhaled breath is feasible for mild cognitive impairment detection: A diagnostic study with portable micro-gas chromatography.

BackgroundMild cognitive impairment (MCI) is an important prodromal stage of Alzheimer's disease (AD), affecting 69 million individuals worldwide. At present, there is a lack of a community-applicable tool for MCI screening. Exhaled breath volatile organic compounds (VOCs) have been used to distinguish MCI from cognitively normal (CN) individuals only in small sample size studies and the efficacy has not been compared with blood biomarkers.

Translocation, Transformation, and Phytotoxicity of Sulfadiazine and -Acetylsulfadiazine in Rice Plants.

This study investigates the uptake, biotransformation, and phytotoxicity of sulfadiazine (SDZ) and its acetyl derivative -acetylsulfadiazine (NASDZ) in rice. Results showed that rice was more tolerant to NASDZ, with lower malondialdehyde and reactive oxygen species levels but higher antioxidant enzyme activities (SOD, POD, and CAT). The maximum accumulations of SDZ in roots and shoots were 19.

Improved analysis with spectral-domain optical coherence tomography angiography for evaluating vascular damage in exfoliation syndrome.

Purpose: To assess microvascular damage in exfoliation syndrome (XFS) patients with spectral-domain optical coherence tomography (OCT) and the correlations between OCT angiography (OCTA) parameters and systemic blood parameters in XFS.

Methods: Twenty-one XFS eyes and 23 healthy eyes were included in this cross-sectional study. The foveal avascular zone (FAZ) area, vessel density (VD), thickness of the layers of the ganglion cell complex (GCC), homocysteine (Hcy) level, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were compared between the two groups.

Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study.

Rationale: Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established method to validate endpoints for clinical trials and cardiovascular epidemiology cohorts; however, a protocol to adjudicate hospitalizations for COVID-19 among epidemiology cohorts was lacking.

Objectives: We developed a protocol to ascertain and adjudicate hospitalized COVID-19 across a meta-cohort of 14 US prospective cohort studies.

Transcriptomic and metabolomic analyses reveal the mechanism of color difference between two kinds of before and after drying.

Introduction: Cistanche deserticola is an important traditional Chinese herbal medicine. The fresh cistanche squamous stem is typically yellow-white and brown after drying. Oil cistanche is a cistanche variant with a purple squamous stem that turns black after drying.

Health effects of astaxanthin in the intestinal tract of yellow-feathered broilers.

Astaxanthin (AST), a keto carotenoid, is widely recognized for its antioxidant, anti-inflammatory, and apoptosis-regulating properties, but its effects on intestinal health have not been elucidated. Therefore, this experiment aimed to investigate the effects of astaxanthin on intestinal morphology, barrier function, mucosal immunity, and cecal flora in yellow-feathered broilers, and to explore the potential mechanisms. A total of 288 male yellow-feathered broilers (1-day-old) were randomly allocated to four groups with six replicates of 12 birds each.

Incidence trends of pediatric psoriasis in 1990-2021: findings from the Global Burden of Disease Study 2021.

Background: Pediatric psoriasis is a chronic inflammatory skin disease that poses unique challenges in diagnosis and management. While studies from high-income countries have reported rising incidence trends, global data on the incidence of pediatric psoriasis remain scarce.

Objective: To provide a comprehensive description of pediatric psoriasis incidence at the global, regional, and national levels.

Impacts of climate change on the suitable habitat of Angelica sinensis and analysis of its drivers in China.

Climate change is shifting optimal habitats for medicinal plants, potentially compromising the efficacy and therapeutic value of herbal remedies. Global warming and increased extreme weather events threaten the sustainability and pharmaceutical integrity of Angelica sinensis (Oliv.) Diels (A.

Role of drug induced nuclear CTSL (nCTSL) in DNA damage response in cancer- therapeutic implications.

In our efforts to enhance sensitivity to PARP inhibitors, we identified clofarabine (CLF) as a potential therapy for drug-resistant ovarian cancer and nuclear trafficking of Cathepsin L (CTSL) as a treatment- responsive biomarker. Using PARP inhibitor-sensitive and -resistant OC cell lines, ex vivo cultures of patient-derived ovarian ascites (OVA), primary ovarian tumors, and xenografts (PDX), we found that CLF monotherapy induces nuclear CTSL (nCTSL) in CLF-responsive cells (CLF-r) and sensitizes them to PARP inhibitors olaparib and rucaparib. In CLF non-responsive cells (CLF-nr), a combination of CLF with olaparib is necessary for nCTSL trafficking and synergy.

Effects of Dietary Nano-Composite of Copper and Carbon on Antioxidant Capacity, Immunity, and Cecal Microbiota of Weaned Ira White Rabbits.

This experiment investigated the effects of dietary supplementation with nano-composites of copper and carbon (NCCC) on antioxidants, immune functions, and the cecum microbiota of weaned Ira white rabbits. A total of 240 weaned 35-day-old Ira white rabbits were randomly allocated to five dietary treatments ( = 6 per treatment, each replicate consisted of eight rabbits) that included the control group (CON) with a basal diet, the SAL group with 60 mg/kg salinomycin (SAL) in addition to the basal diet, and the NCCC I, II, III groups, which were supplemented with 50, 100, and 200 mg/kg NCCC, respectively, in addition to the basal diet. The test lasted for 28 d.

Neoplasms in the Nasal Cavity Identified and Tracked with an Artificial Intelligence-Assisted Nasal Endoscopic Diagnostic System.

Objective: We aim to construct an artificial intelligence (AI)-assisted nasal endoscopy diagnostic system capable of preliminary differentiation and identification of nasal neoplasia properties, as well as intraoperative tracking, providing an important basis for nasal endoscopic surgery.

Methods: We retrospectively analyzed 1050 video data of nasal endoscopic surgeries involving four types of nasal neoplasms. Using Deep Snake, U-Net, and Att-Res2-UNet, we developed a nasal neoplastic detection network based on endoscopic images.

Longitudinal Changes of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in Highly Myopic Glaucoma: A 3-Year Cohort Study.

Purpose: To describe the longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGC-IPL) thicknesses in highly myopic eyes with and without glaucoma and to investigate the effects of high myopia (HM) on the sectoral patterns of pRNFL and mGC-IPL thinning.

Design: Longitudinal cohort study.

Participants: A total of 243 eyes from 243 individuals with 3-year follow-up were included in this study: 109 eyes in the HM group, 64 eyes in the open-angle glaucoma (OAG) group, and 70 eyes in the highly myopic glaucoma (HMG) group.

Unlocking emotional well-being: Evaluation of a stress mindset intervention with a metacognitive approach.

Although there is a growing body of research on the effects of a stress mindset on health and well-being, knowledge of the effectiveness of stress mindset interventions in real-world situations is limited and primarily supported by evidence from Western cultural contexts. We examined the effects of a stress mindset intervention with a metacognitive approach on emotional well-being (negative affect, positive affect, anxious affect, and life satisfaction) over 4 months (i.e.

Evaluating the Relationship between Cathepsins and Papillary Thyroid Carcinoma: A Mendelian Randomization Study.

Background: Papillary Thyroid Carcinoma (PTC) is the most common thyroid cancer, with an etiology and progression that are not fully understood. Research suggests a link between cathepsins and PTC, but the causal nature of this link is unclear. This study uses Mendelian Randomization (MR) to investigate if cathepsins causally influence PTC risk.

Heterogeneity in racist events and posttraumatic mental health among Black, Indigenous, People of Color (BIPOC) first responders.

Black, Indigenous, People of Color (BIPOC) first responders in Canada report experiencing racism and an increased risk of trauma-related mental health symptoms. Using a BIPOC first responder sample in Canada, the present study examined subgroups of BIPOC first responders based on the frequency of different types of racist events, and their relations with mental health symptoms (posttraumatic stress disorder [PTSD] symptom clusters of intrusion, avoidance, negative alterations in cognitions and mood [NACM], and alterations in arousal and reactivity [AAR]; depression severity; anxiety severity). The sample included 196 BIPOC first responders who reported more than one traumatic experience (= 35.

Unraveling the Relationship Between English Learning Burnout and Academic Achievement: The Mediating Role of English Learning Resilience.

Although burgeoning research has been conducted on the role of negative emotions (e.g., English learning burnout) in affecting students' academic achievement, there are limited studies on the intricate working mechanism between these two factors.

KPNA2/KPNB1 promotes the malignant progression of gastric cancer induced by M2 macrophage polarization.

Macrophages in the tumor microenvironment (TME) regulated gastric cancer progression, but the mechanism of macrophage polarization in gastric cancer progression remained unclear. This study mainly explored the molecular mechanism of macrophage polarization in the tumor microenvironment and its impact on the progression of gastric cancer. KPNA2 and KPNB1 expressions in cancer tissues and adjacent non-cancerous tissues were quantified via RT-qPCR and western blot.