Myeloma cell intrinsic ANXA1 elevation and T cell dysfunction contribute to BCMA-negative relapse after CAR-T therapy.

Multiple myeloma (MM) relapse still occurs after a durable response to anti-BCMA chimeric antigen receptor-engineered T (CAR-T) cell therapy with less-defined factors. Herein, we investigated a CAR-T-exposed MM patient who relapsed after 12 months of remission by single-cell transcriptome sequencing. The bone marrow CAR-T population at relapse exhibited exhaustion and proliferation attenuation.

Effect of early application of a sodium-glucose cotransporter-2 inhibitor on ventricular remodelling and prognosis in patients with anterior wall acute myocardial infarction.

Background: The role of sodium-glucose cotransporter-2 inhibitors in patients with acute myocardial infarction remains elusive.

Aim: To evaluate the effect of early application of a sodium-glucose cotransporter-2 inhibitor on ventricular remodelling and prognosis in patients with anterior wall acute myocardial infarction.

Methods: In this prospective study, 102 patients diagnosed with anterior wall acute myocardial infarction were enrolled and divided into intervention and control groups according to the use of dapagliflozin within 24hours after admission.

Multi-scale carbon@Sb mesoporous composites activated by localized electrochemical pulverization as high-rate and long-life anode materials for potassium-ion batteries.

Hard carbon and antimony (Sb) are two promising anode candidates for future potassium-ion batteries. Herein, we successfully solve the low-capacity problem of highly conductive carbon and poor cycling stability of high-capacity Sb through uniformly dispersing and embedding sub-nano and nanoscale Sb particles (∼36.4 wt%) inside nitrogen-doped two-dimensional hard carbon nanosheets to form a multi-scale carbon@Sb mesoporous composite, denoted as Sb@HCNS.

TERT-TP53 mutations: a novel biomarker pair for hepatocellular carcinoma recurrence and prognosis.

Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, and ranks among the most lethal malignancies globally, primarily due to its high rates of recurrence and metastasis. Despite the urgency, no reliable biomarkers currently exist for predicting tumor recurrence in HCC. Telomerase reverse transcriptase (TERT) promoter mutations (TERTpm) and cellular tumor antigen p53 mutations (TP53m) have been frequently documented in HCC, but their combined clinical significance remains undefined.

Controlins I-X, Resin Glycosides from the Seeds of and Their Biological Activities.

Ten new resin glycosides, controlins I-X (-), were isolated from the seeds of . Their structures were established by spectroscopic analysis as well as by chemical means. Compounds were identified as glycosidic acid methyl esters, considered as artifacts generated via transesterification with MeOH from natural resin glycosides.

Effect of Feeding Mice Soluble Metals and Heavy Metal Contaminated Soil on Feces Metal Concentrations.

The effect of heavy metal availability and interaction in feed on feces heavy metal excretion in mice has rarely been investigated. In this work, feed containing a polluted soil (total Cd = 6.34, total Pb = 387 mg kg) amended with phosphate, bentonite and lime, or feed spiked with soluble Pb and Cd were fed to mice for 10 days.

Inhibition of Endothelial-Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats.

Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage to heart valves. Recently, endothelial‒mesenchymal transition (EndMT), in which activin plays an important role, has been shown to be an important factor in RHD valvular injury. However, the mechanism of activin activity and EndMT in RHD valvular injury is not clear.

Ursonic Acid Ameliorates HO-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.

Growing evidence suggests that plant compounds are emerging as a tremendous source for slowing the onset and progression of Alzheimer's disease (AD). Ursonic acid (UNA) is a naturally occurring pentacyclic triterpenoid with some hypoglycemic, anticancer, and antiinflammatory activities. However, the pharmacological effects of UNA on AD are still unknown.

Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure.

Background: Despite the insights into the role of aldehyde dehydrogenase 1 family member A1 (ALDH1A1) in various liver diseases, the expression and its prognostic significance in patients with hepatitis E virus-related acute liver failure (HEV-ALF) remain unclear. This study delved into the assessment of serum exosome-derived ALDH1A1 expression and its prognostic implications for HEV-ALF patients.

Methods: Between January 2018 and December 2023, a total of 226 individuals with acute hepatitis E (AHE) and 210 patients with HEV-ALF were recruited from member units of Chinese Consortium for the Study of Hepatitis E.

Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps.

Our previous study has shown that neutrophil extracellular traps (NETs) were associated with idiopathic inflammatory myopathy-related interstitial lung disease (IIM-ILD). Colchicine plays an anti-inflammatory role mainly by inhibiting the activity and chemotaxis of neutrophils. This study aims to verify therapeutic effects and mechanism of colchicine in IIM-ILD.

Parallel gut-to-brain pathways orchestrate feeding behaviors.

The caudal nucleus of the solitary tract (cNTS) in the brainstem serves as a hub for integrating interoceptive cues from diverse sensory pathways. However, the mechanisms by which cNTS neurons transform these signals into behaviors remain debated. We analyzed 18 cNTS-Cre mouse lines and cataloged the dynamics of nine cNTS cell types during feeding.

A Randomized Double-blind Trial of 5% Dextrose Versus Corticosteroid Hydrodissection for Meralgia Paresthetica.

Background: Ultrasound-guided 5% dextrose (D5W) hydrodissection provides  favorable outcomes for treating peripheral entrapment neuropathies; its safety is well recognized. However, clinical evidence regarding the use of D5W hydrodissection for meralgia paresthetica (MP) is limited. Although corticosteroids are the most common injectates, the possible adverse effects are a big concern.

Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review.

Objective: Sarcopenia is a significant healthcare challenge in the aging population. Oxidative stress (OS) is acknowledged to play a pivotal role in the pathological progression of sarcopenia. Numerous studies have demonstrated that mitigating or eliminating OS can ameliorate the pathological manifestations associated with sarcopenia.

A novel mouse model of myositis-associated interstitial lung disease was established by using TLR9 agonist combined with muscle homogenate.

Our group previously demonstrated that NETs were involved in interstitial lung diseases (ILD) among patients with idiopathic inflammatory myopathies (IIM) and the experimental autoimmune myositis (EAM) mouse model and that NETs activated lung fibroblasts through the TLR9-miR7-Smad2 axis. This study aimed to establish a novel mouse model of myositis-associated interstitial lung disease (MAILD) by using a TLR9 agonist (ODN2395). ODN2395 and muscle homogenate were used to induce MAILD in BALB/c mice.

Amorphous Photonic Structure Patterns with Thin Film Interference Effects for Multilevel Anticounterfeiting.

Colloidal photonic structures with the ability to control and manipulate light propagation offer long-term color stability, low optical loss, and angle-dependent color properties, while combinations of different photonic structures across multiple scales provide an extensive color range and enhanced optical functionalities, presenting significant potential for advanced anticounterfeiting applications. However, the proper design or manufacture of such complex structures is still challenging. In this study, amorphous photonic structures (APSs) with thin film interference (TFI) effects were fabricated for multilevel anticounterfeiting.

Rapid fabrication of tunable structural color patterns by spray-coating.

Structural color, a color generated based on physical principles, has broad applications such as displays, optical sensors, and anti-counterfeiting. Traditional methods for producing structural colors are often complex and time-consuming, whereas spray-coating colloidal self-assembly offers a simple and controllable alternative. However, due to the high-pressure atomization process, colloidal inks often form amorphous photonic structures (APSs), making it challenging to precisely control the assembly of colloidal particles on substrates to achieve ordered structures.

Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer.

The presence of microplastics within the human body has raised significant concerns about their potential health implications. Numerous studies have supported the hypothesis that the accumulation of microplastics can trigger inflammatory responses, disrupt the microbiome, and provoke immune reactions due to their physicochemical properties. Chronic inflammation, characterized by tissue damage, angiogenesis, and fibrosis, plays a crucial role in cancer development.

CN/Se-CNTs as Advanced Metal-Free Catalysts for the Photoassisted Electrocatalytic Oxygen Evolution Reaction.

Photoassisted electrocatalysis is a frontier direction of electrocatalysis for promoting energy conversion. In this work, a metal-free CN/Se-CNTs is reported as a novel catalyst for photoassisted electrocatalytic oxygen evolution reaction (OER). CN has an appropriate bandgap, high specific surface area, and long-term stability.

Facile Synthesis of Soft Core-Shell Nanospheres for Constructing Multiresponsive Photonic Crystal Security Patterns.

Responsive photonic crystals (RPCs) presenting tunable structural colors under external stimuli are widely applied in the fields of dynamic displays, sensors, and anticounterfeiting. However, the development of multiresponsive photonic crystal (MRPC) films possessing versatile variable optical properties remains a significant challenge due to the tedious synthetic procedure of multifunctional building blocks and complex assembly processes, thereby constraining their extensive applications. In the present work, a series of soft nanospheres with a hydrophobic cores and responsive hydrophilic shells have been synthesized by a facile one-step surfactant-free emulsion polymerization method.