Two-year survival after scheduled extubation in patients with pneumonia or ARDS: a prospective observational study.

Purpose: To report two-year survival after scheduled extubation in patients with pneumonia or acute respiratory distress syndrome (ARDS).

Methods: This was a prospective observational study performed in a respiratory ICU of a teaching hospital. Pneumonia or ARDS patients who successfully completed a spontaneous breathing trial were enrolled.

PaCO is nonlinearly associated with NIV failure in patients with hypoxemic respiratory failure.

Objective: To explore the association between PaCO and noninvasive ventilation (NIV) failure in patients with hypoxemic respiratory failure.

Methods: A retrospective study was performed in a respiratory ICU of a teaching hospital. Patients admitted to ICU between 2011 and 2019 were screened.

A Novel Scale to Assess Humidification during Noninvasive Ventilation: A Prospective Observational Study.

Objective: To develop a novel scale to assess humidification during noninvasive ventilation (NIV).

Methods: This study was performed in an ICU of a teaching hospital. Three ICU practitioners with more than 10 years of clinical experience developed an oral humidification scale with a range of 1-4 points.

Prediction of noninvasive ventilation failure using the ROX index in patients with de novo acute respiratory failure.

Background: The ratio of SpO/FiO to respiratory rate (ROX) index is commonly used to predict the failure of high-flow nasal cannula. However, its predictive power for noninvasive ventilation (NIV) failure is unclear.

Methods: This was a secondary analysis of a multicenter prospective observational study, intended to update risk scoring.

An updated HACOR score for predicting the failure of noninvasive ventilation: a multicenter prospective observational study.

Background: Heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) have been used to predict noninvasive ventilation (NIV) failure. However, the HACOR score fails to consider baseline data. Here, we aimed to update the HACOR score to take into account baseline data and test its predictive power for NIV failure primarily after 1-2 h of NIV.

Weak cough is associated with increased mortality in COPD patients with scheduled extubation: a two-year follow-up study.

Background: Cough strength is associated with short-term outcome in patients with scheduled extubation who successfully complete a spontaneous breathing trial (SBT). However, the long-term outcome is unclear.

Methods: This was a prospective observational study performed in a respiratory ICU of a teaching hospital.

Early assessment of the efficacy of noninvasive ventilation tested by HACOR score to avoid delayed intubation in patients with moderate to severe ARDS.

Background: Use of noninvasive ventilation (NIV) in patients with moderate to severe ARDS is controversial. We aimed to use HACOR (combination of heart rate, acidosis, consciousness, oxygenation and respiratory rate) score to comprehensively assess the efficacy of NIV in ARDS patients with PaO/FiO ⩽ 150 mmHg.

Methods: Secondary analysis was performed using the data collected from two databases.

Predictors of the Failure of Noninvasive Ventilation in Patients With Acute Respiratory Failure Caused by Severe Acute Pancreatitis: A Prospective Observational Study.

Objective: The aim of the study was to identify risk factors associated with the failure of noninvasive ventilation (NIV) in patients with severe acute pancreatitis (SAP).

Methods: Patients who received NIV as a first-line therapy because of acute respiratory failure caused by SAP were enrolled.

Results: A total of 133 patients were enrolled.

Impact of HACOR Score on Noninvasive Ventilation Failure in Non-COPD Patients with Acute-on-Chronic Respiratory Failure.

Background: A rating scale that takes into account heart rate, acidosis, consciousness, oxygenation, and respiratory rate (the HACOR score) has been used to predict noninvasive ventilation (NIV) failure in patients with chronic obstructive pulmonary disease (COPD). However, the HACOR score has not been used to predict NIV failure in non-COPD patients with acute-on-chronic respiratory failure.

Methods: This study was performed in the respiratory intensive care unit of a teaching hospital.

Association between ARDS Etiology and Risk of Noninvasive Ventilation Failure.

The etiology of acute respiratory distress syndrome (ARDS) may play an important role in the failure of noninvasive ventilation (NIV). To explore the association between ARDS etiology and risk of NIV failure. A multicenter prospective observational study was performed in 17 intensive care units in China from September 2017 to December 2019.

Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: a prospective observational study.

Background: Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes of delirium in NIV patients.

Methods: A prospective observational study was performed in an intensive care unit (ICU) of a teaching hospital.

Head-To-Head Comparison of Treatment Failure and Costs among COPD Patients Who Used Noninvasive Ventilation in the Ward versus in the ICU: A Propensity-Matched Cohort Study.

Background: Head-to-head comparison of treatment failure and costs among chronic obstruct pulmonary disease (COPD) patients who used noninvasive ventilation (NIV) in the ward versus in the ICU is lacking.

Methods: This retrospective study was performed in a department of respiratory and critical care medicine in a teaching hospital. COPD patients who used NIV in the respiratory ward or respiratory ICU were screened.

Risk Factors Associated with Late Failure of Noninvasive Ventilation in Patients with Chronic Obstructive Pulmonary Disease.

Background: Risk factors for noninvasive ventilation (NIV) failure after initial success are not fully clear in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).

Methods: Patients who received NIV beyond 48 h due to acute exacerbation of COPD were enrolled. However, we excluded those whose pH was higher than 7.

Correlation between the variables collected at admission and progression to severe cases during hospitalization among patients with COVID-19 in Chongqing.

Mortality is high among severe patients with 2019 novel coronavirus-infected disease (COVID-19). Early prediction of progression to severe cases is needed. We retrospectively collected patients with COVID-19 in two hospital of Chongqing from 1st January to 29th February 2020.

Role of Rs763361 Polymorphism in Susceptibility to Multiple Autoimmune Diseases.

: Gly307Ser (rs763361) polymorphism in () gene has been implicated in susceptibility to autoimmune diseases (ADs) with controversial results. This study aimed to conduct a meta-analysis for examining the relationship between rs763361 polymorphism and ADs risk. : a literature search was performed to identify relevant studies published in Embase, PubMed, Wanfang, and China National Knowledge Infrastructure.

Early prediction of noninvasive ventilation failure in COPD patients: derivation, internal validation, and external validation of a simple risk score.

Background: Early identification of noninvasive ventilation (NIV) failure is a promising strategy for reducing mortality in chronic obstructive pulmonary disease (COPD) patients. However, a risk-scoring system is lacking.

Methods: To develop a scale to predict NIV failure, 500 COPD patients were enrolled in a derivation cohort.

Association between T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Genetic Polymorphisms and Susceptibility to Autoimmune Diseases.

: Polymorphisms in T-cell immunoglobulin and mucin domain 3 (TIM-3) gene have been implicated in susceptibility to autoimmune diseases (ADs) with inconsistent results. The aim of this study was to perform meta-analyses for clarifying the relationship between them. : All relevant case-control studies were searched in PubMed, Embase, Wanfang, and China National Knowledge Infrastructure.

Resource use, characteristics and outcomes of prolonged non-invasive ventilation: a single-centre observational study in China.

Objective: To report the resource use, characteristics and outcomes of patients with prolonged non-invasive ventilation (NIV).

Design: A single-centre observational study.

Setting: An intensive care unit of a teaching hospital.

Decreasing re-intubation using prophylactic noninvasive ventilation in elderly patients: A propensity-matched study.

Purpose: Prophylactic noninvasive ventilation (NIV) reduces re-intubation in high-risk patients. However, its effects in elderly patients remain unclear. Here, we investigated the efficacy of prophylactic NIV in elderly patients after a planned extubation.

Noninvasive ventilation failure in pneumonia patients ≥65years old: The role of cough strength.

Purpose: To explore the association between cough strength and outcomes in elderly patients who received noninvasive ventilation (NIV) due to acute respiratory failure caused by pneumonia.

Materials And Methods: We enrolled patients ≥65years old with acute respiratory failure caused by pneumonia. Just before NIV treatment, cough strength was assessed on a cough-strength scale graded from 0 to 5.

Use of Cough Peak Flow Measured by a Ventilator to Predict Re-Intubation When a Spirometer Is Unavailable.

Background: A ventilator includes the function to measure flow velocity. We aimed to compare the predictive accuracy for re-intubation diagnosed by cough peak flow (CPF) measured by a spirometer and a ventilator.

Methods: Endotracheally intubated subjects who passed a spontaneous breathing trial were enrolled.

Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients.

Purpose: To develop and validate a scale using variables easily obtained at the bedside for prediction of failure of noninvasive ventilation (NIV) in hypoxemic patients.

Methods: The test cohort comprised 449 patients with hypoxemia who were receiving NIV. This cohort was used to develop a scale that considers heart rate, acidosis, consciousness, oxygenation, and respiratory rate (referred to as the HACOR scale) to predict NIV failure, defined as need for intubation after NIV intervention.

Noninvasive ventilation for avoidance of reintubation in patients with various cough strength.

Background: Reintubation is associated with high mortality. Identification of methods to avoid reintubation is needed. The aim of this study was to assess whether prophylactic noninvasive ventilation (NIV) would benefit patients with various cough strengths.