Promotion of mature angiogenesis in ischemic stroke by Taohong Siwu decoction through glycolysis activation.

Mature angiogenesis plays a critical role in improving cerebral ischemia-reperfusion injury (CIRI). Glycolysis serves as the primary energy source for brain microvascular endothelial cells (BMECs), whereas other vascular cells rely on aerobic respiration. Therefore, intercellular variations in energy metabolism could influence mature angiogenesis.

Treating ischemic stroke by improving vascular structure and promoting angiogenesis using Taohong Siwu Decoction: An integrative pharmacology strategy.

Ethnopharmacological Relevance: Neovessels represent a crucial therapeutic target and strategy for repairing ischemic tissue. Taohong Siwu Decoction (THSWD) exhibits potential in promoting angiogenesis to address ischemic stroke (IS). However, its impact on neovessel structure and function, alongside the underlying molecular mechanisms, remains elusive.

Probiotic Consortia Protect the Intestine Against Radiation Injury by Improving Intestinal Epithelial Homeostasis.

Purpose: Radiation-induced intestinal injury (RIII) commonly occur during abdominal-pelvic cancer radiation therapy; however, no effective prophylactic or therapeutic agents are available to manage RIII currently. This study aimed to clarify the potential of probiotic consortium supplementation in alleviating RIII.

Methods And Materials: Male C57BL/6J mice were orally administered a probiotic mixture comprising Bifidobacterium longum BL21, Lactobacillus paracasei LC86, and Lactobacillus plantarum Lp90 for 30 days before exposure to 13 Gy of whole abdominal irradiation.

Ultra-performance liquid chromatography-quadrupole time-of-flight mass combined with UNIFI to study the mechanism of Tao Hong Si Wu Decoction in the treatment of postpartum blood stasis.

Postpartum hemorrhage can lead to a variety of maternal complications. Tao Hong Si Wu Decoction (THSWD) is a traditional Chinese medicine used for treating gynecological diseases. However, the active ingredients of THSWD and its pharmacological mechanism of treatment for postpartum blood stasis still remained unclear.

Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo.

The small intestine exhibits remarkable sensitivity to ionizing radiation (IR), which significantly hampers the effectiveness of radiotherapy in the treatment of abdominal and pelvic tumors. Unfortunately, no effective medications are available to treat radiation-induced intestinal damage (RIID). Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside), is a coumarin derivative extracted from the Chinese herb Cortex Fraxini.

Occurrence, behaviors, and fate of per- and polyfluoroalkyl substances (PFASs) in typical municipal solid waste disposal sites.

Per- and polyfluoroalkyl substances (PFASs) have become a crucial environmental concern owing to their exceptional persistence, ability to bioaccumulate within ecosystems, and potential to adversely affect biota. Products and materials containing PFASs are usually discarded into municipal solid waste (MSW) at the end of their life cycle, and the fate of PFASs may differ when different disposal methods of MSWs are employed. To date, limited research has focus on the occurrence, behaviors, and fate of PFASs emitted from various MSW disposal sites.

Traumatic main airway rupture successfully rescued by extracorporeal membrane oxygenation: A case report.

The chest is a common site for traumatic injury; however, rupture of the main airway after chest trauma is a rare and potentially fatal condition. The present study demonstrated that extracorporeal membrane oxygenation (ECMO) may serve a crucial role in the effective conventional treatment of patients with severe chest trauma, ECMO was used before tracheal repair surgery to prevent hypoxia during surgery. When effective ventilation of the patient cannot occur without assistance, ECMO support is considered to be essential in ensuring effective gas exchange.

[Active components and potential mechanism of Taohong Siwu Decoction in regulating ischemic stroke based on target cell trapping combined with network pharmacology, molecular docking, and experimental validation].

The potential anti-stroke active components in Taohong Siwu Decoction(THSWD) were identified by target cell trapping coupled with ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry(UPLC-Q-TOF-MS). The underlying mechanism of active components in THSWD in the treatment of ischemic stroke(IS) was explored by network pharmacology, molecular docking, and experimental validation. The UPLC-Q-TOF-MS technology combined with the UNIFI data analysis platform was used to analyze the composition of the cellular fragmentation fluid after co-incubation of THSWD with target cells.

Honokiol prevents lung metastasis of triple-negative breast cancer by regulating polarization and recruitment of macrophages.

Metastasis is the leading cause of breast cancer-associated death. Lung metastasis commonly occurs in triple-negative breast cancer (TNBC) metastasis, worsening the TNBC prognosis. Considering their role in tumor progression and metastasis, tumor-associated macrophages (TAMs) are essential therapeutic targets in cancer therapy.

Perillaldehyde Mitigates Ionizing Radiation-Induced Intestinal Injury by Inhibiting Ferroptosis via the Nrf2 Signaling Pathway.

Scope: Gastrointestinal toxicity is one of the major side effects of abdominopelvic tumor radiotherapy. Studies have shown that perillaldehyde (PAH) has antioxidant, antiinflammatory, antimicrobial activity, and antitumor effects. This study aims to determine whether PAH has radioprotective effects on radiation-induced intestinal injury and explore the underlying mechanisms.

Age is Not the Most Important Factor in the Prognosis of Femoral Neck Fracture: An Analysis of Long-Term Clinical Follow-Up.

Objective: The prognosis of femoral neck fractures is affected by factors including age and type of fracture. This study aimed to explore the associations among postsurgical outcomes of internal fixation for femoral neck fracture (healing rate, necrosis rate, and joint function score) and age and type of fracture.

Methods: We retrospectively analyzed 297 cases of femoral neck fracture treated with internal fixation between February 2008 and October 2018.

DRLIE: Flexible Low-Light Image Enhancement via Disentangled Representations.

Low-light image enhancement (LIME) aims to convert images with unsatisfied lighting into desired ones. Different from existing methods that manipulate illumination in uncontrollable manners, we propose a flexible framework to take user-specified guide images as references to improve the practicability. To achieve the goal, this article models an image as the combination of two components, that is, content and exposure attribute, from an information decoupling perspective.

Fenton micro-reactor on a bubble: A novel microbubble-triggered simultaneous capture and catalytic oxidation strategy for recalcitrant organic pollutant removal.

A novel catalyst-functionalized microbubble system was developed to trigger both of the Fenton reaction and the flotation separation on the gas-liquid interface of bubbles for efficiently removing the recalcitrant organic pollutants from waters. The Fe(II)-functionalized colloidal microbubbles (FCMBs) were featured as large specific surface area, great bubble density and high ·OH activation capacity. Approximately 98.

(-)-Epigallocatechin-3-Gallate (EGCG) Modulates the Composition of the Gut Microbiota to Protect Against Radiation-Induced Intestinal Injury in Mice.

The high radiosensitivity of the intestinal epithelium limits the outcomes of radiotherapy against abdominal malignancies, which results in poor prognosis. Currently, no effective prophylactic or therapeutic strategy is available to mitigate radiation toxicity in the intestine. Our previous study revealed that the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) attenuates radiation-induced intestinal injury (RIII).

Bioprinting small-diameter vascular vessel with endothelium and smooth muscle by the approach of two-step crosslinking process.

Three-dimensional bioprinting shows great potential for autologous vascular grafts due to its simplicity, accuracy, and flexibility. The 6-mm-diameter vascular grafts are used in clinic. However, producing small-diameter vascular grafts are still an enormous challenge.

Dysbiosis of Gut Microbiota Is Associated With the Progression of Radiation-Induced Intestinal Injury and Is Alleviated by Oral Compound Probiotics in Mouse Model.

The acute radiation-induced intestinal injury (RIII) has raised much concerns and is influenced by non-cytocidal radiation effects including the perturbations in gut microbiota. Although a number of studies have reported alteration in gut microbiota following radiation, little is known about its dynamic variation in the progression of acute RIII. In this study, mouse model were treated with total body irradiation (TBI) of 0, 4, 8 and 12 Gy, and the intestinal tissues and fecal samples were collected at 6 h, 3.

Removal of micron-scale microplastic particles from different waters with efficient tool of surface-functionalized microbubbles.

Microplastic (MP) contamination in water has garnered significantly global concerns. The MP removal particularly challenges when the particle size decreases to several microns and other contaminants co-exist. This study used the coagulative colloidal gas aphrons (CCGAs) to simultaneously remove the micron-scale MP particles (~5 µm in diameter) and dissolved organic matter (DOM).

Lability-specific enrichment of typical engineered metal (oxide) nanoparticles by surface-functionalized microbubbles from waters.

Enrichment of metallic engineered nanoparticles (MENPs) from environmental waters is a prerequisite for their removal, reliable analyses, and environmental process interpretations. This work investigated the enrichment of typical MENPs with different degrees of lability using surface-functionalized microbbubles. During the process, the transformation/dissolution characteristics of MENPs were considered, and the impact of surfactant or coagulant dose, pH of MENP suspensions, and water matrix was systematically investigated.

What occurs in colloidal gas aphron-induced separation of titanium dioxide nanoparticles? Particle fate analysis by tracking technologies.

As an important method of enriching, separating and removing nanoparticles, colloidal gas aphrons (CGAs) need to be investigated for the fate and interfacial behaviors of particles during the process. It is beneficial to sufficiently interpreting the process performance and mechanisms. This study employed complementary tracking technologies to analyze the extensively-used engineered nanoparticles - TiO nanoparticles (TiO-NPs) in effluent and floats of CGA process.

Comparison of coagulative colloidal microbubbles with monomeric and polymeric inorganic coagulants for tertiary treatment of distillery wastewater.

The flotation using coagulative colloidal gas aphrons (CCGAs) is of great potential in effectively removing the recalcitrant dissolved organic matter (DOM) and colorants from the bio-chemically treated cassava distillery wastewater. As bubble modifier, the monomeric and polymeric inorganic coagulants need to be studied considering their distinct influence on the surfactant/coagulant complex, the properties of colloidal aphrons as well as the process performance and mechanisms. Such studies help to create robust CCGAs with high flotation potential.

Combination free foot flaps for digit reconstruction: A retrospective analysis of 37 cases.

Combination foot flaps for digit reconstruction was previously introduced by our group as an alternative method for toe-to-hand transfer. The aim of this study was to analyze our experience with the combination foot flaps and to present the surgical refinements that were introduced. A prospective study was conducted including all combination foot flaps performed at our hospital since September 2009.

A flap based on the plantar digital artery arch branch to improve appearance of reconstructed fingers: Anatomical and clinical application.

Aim: To investigate blood supply features of the flap based on the plantar digital artery arch and arch branch artery, and the treatment of outcomes of reconstructed fingers by the plantar digital artery arch branch island flap.

Methods: Eight fresh foot specimens were employed with red emulsion infusion and microdissection. The vascular organization was observed in the second toe, such as initiation site, the course, and the number of the plantar digital artery arch branch.

Replantation or revascularization for the treatment of hand degloving injuries.

Purpose: The purpose of this study was to explore effective strategies of replantation or revascularization for the treatment of hand degloving injuries.

Methods: Ten patients who had received replantation or revascularization surgery for hand degloving injury between 2002 and 2014 were included for this study. The average age at the time of surgery was 34.