Publications by authors named "Linfeng Le"
Given the complexity and heterogeneity of Alzheimer's disease (AD) pathology, targeted monotherapy drugs may not be effective. Therefore, synergistic combination therapy of curcumin and Mito Q was proposed and evaluated in a triple-transgenic AD model mice (3 × Tg-AD mice). The cognitive ability was assessed using behavioral tests and typical pathological changes were observed through Western blotting and histological analysis.
View Article and Find Full Text PDFZinc exacerbates tau-induced Alzheimer-like pathology in C57BL/6J mice.
Int J Biol Macromol
July 2023
The pathogenesis of Alzheimer's disease (AD) is highly complex and multifactorial. Compared with Aβ, the pathological changes associated with tau are more related to the clinical symptoms and more indicative of the severity of AD. Studies have shown that the direct interaction between tau and Zn plays an important role in tau toxicity, however, the mechanism by which Zn contributes to tau-induced neurotoxicity is not fully understood.
View Article and Find Full Text PDFEbselen Interferes with Alzheimer's Disease by Regulating Mitochondrial Function.
Antioxidants (Basel)
July 2022
Article Synopsis
- This study examines the effects of Ebselen, a compound previously shown to improve cognition in mice with Alzheimer's, at a lower concentration to avoid toxicity.
- Behavioral experiments, along with various biochemical assessments, were conducted to evaluate the impact of Ebselen on cognitive function and AD-related pathology in triple-transgenic mice.
- Results revealed that Ebselen not only enhanced cognitive abilities and reduced toxic protein levels but also repaired mitochondrial function, suggesting that its therapeutic effect may be linked to mitochondrial protection in Alzheimer’s disease.