The Optimization of Culture Conditions for Injectable Recombinant Collagen Hydrogel Preparation Using Machine Learning.

Injectable recombinant collagen hydrogels (RCHs) are crucial in biomedical applications. Culture conditions play an important role in the preparation of hydrogels. However, determining the characteristics of hydrogels under certain conditions and determining the optimal conditions swiftly still remain challenging tasks.

Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L.

Ethnopharmacological Relevance: Sumu (Lignum sappan), the dry heartwood of Caesalpinia sappan L., is a traditional Chinese medicine used as an analgesic and anti-inflammatory agent.

Aim Of The Study: The study aspired to discover natural phosphodiesterase 4 (PDE4) inhibitors with dual anti-inflammatory and antioxidant activities from Sumu for the treatment of chronic obstructive pulmonary disease (COPD).