Two new amino acid-derived oximes from the mangrove-sediment-derived fungus SCSIO 41702.

Two new amino acid-derived oximes -(2-hydroxyimino-4-methyl-pentanoyl)--isoleucine () and -(2-hydroxyimino-4-methyl-pentanoyl)--leucine (), along with two known analogues ()--(2-hydroxyimino-3-phenylpropanoyl)--phenylalanine () and methyl ()-- (2-hydroxyimino-3-phenylpropanoyl)--phenylalaninate (), were isolated from the mangrove-sediment-derived fungus SCSIO 41702. Their structures were determined by spectroscopic analysis. The absolute configurations of and were determined by Marfey's method.

Biomimetic wrinkled prebiotic microspheres with enhanced intestinal retention for hyperphosphatemia and vascular calcification.

It is urgent for patients with chronic kidney disease (CKD) to develop a robust and facile therapy for effective control of serum phosphate and reasonable regulation of gut microbiota, which are aiming to prevent cardiovascular calcification and reduce cardiovascular complications. Here, bioinspired by intestinal microstructures, we developed biomimetic wrinkled prebiotic-containing microspheres with enhanced intestinal retention and absorption for reducing hyperphosphatemia and vascular calcification of CKD model rats. The resultant CSM@5 microspheres exhibited favorable phosphate binding capacity in vitro and could effectively reduce serum concentration of phosphorous in vivo.

Lecanicilliums A-F, Thiodiketopiperazine-Class Alkaloids from a Mangrove Sediment-Derived Fungus .

Six new thiodiketopiperazine-class alkaloids lecanicilliums A-F were isolated from the mangrove sediment-derived fungus SCSIO41702, together with thirteen known analogues. Their structures were determined by spectroscopic analysis. The absolute configurations were determined by quantum chemical calculations.

Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation.

Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata.