In vivo effect of 2,4-dinitro-phenyl-substituted sugar hydrazones and phenylosazone against Trichomonas vaginalis and Tritrichomonas foetus.

Antitrichomonal activity of selected 2,4-dinitro-phenylhydrazones and phenylosazones of sugars was investigated in vitro and in vivo and compared with the activity of tinidazole, an effective therapeutic agent. In experimental infections with Trichomonas vaginalis and Tritrichomonas foetus in mice glycolaldehyde-2,4-dinitro-phenylhydrazone acetate and 2,3-diacetylglycerolaldehyde-2,4-dinitro-phenylhydrazone exhibited an antiparasitic effect slightly inferior to that of tinidazole. Structure-activity relationships are discussed.

Antiprotozoal effects of some hydrazones.

Antiprotozoal effects of hydrazones derived from compounds with 1 to 4 carbon atoms were studied on the model organism Trichomonas vaginalis isolated from a female patient with acute urogenital trichomoniasis.

Antimicrobial effect of sugar osazones and anhydro sugars.

The antimicrobial effect of 14 sugar osazones and anhydro sugars was studied with model strains of Micrococcus luteus, Bacillus licheniformis, Escherichia coli and strains Staphylococcus aureus and Pseudomonas aeruginosa isolated from clinical material. The relationship between the structure of these compounds, their solubility in water and 1-octanol and antimicrobial effect was investigated.

Antitrichomonadal and other biological effects of sugar hydrazones and phenylosazones.

When investigating the possible antitrichomodal effect of 41 phenylsazones, nitro- and dinitro-phenylhydrazones a significant inhibitory effect on multiplication of Trichomonas foetus could be detected in 14 derivatives; eight derivatives were ineffective, other derivatives exhibited only a slight effect. The inhibitory effect of most compounds increased after acetylation. Toxicity of seven effective compounds was determined in vivo.

2-Deoxy-D-lyxo-hexonic acid from 2-deoxy-D-lyxo-hexose by Pseudomonas aeruginosa fermentation.

Aerobic fermentation of media or solutions containing 2-deoxy-D-lyxo-hexose and calcium carbonate by bacterial cells capable of oxidizing aldoses to aldonic acids was used to prepare 2-deoxy-D-lyxo-hexonic acid; the acid was isolated in a 62% yield in the form of its 1,4-lactone.

Biochemical dehydrogenations of saccharides. VII. 2-Deoxy-D-gluconic acid from 2-deoxy-D-glucose.

Fermentation of a medium containing 5% 2-deoxy-D-glucose and barium carbonate by a strain of Pseudomonas aeruginosa yielded barium 2-deoxy-D-gluconate. The yield was 77% theoretical. The strain in question makes it possible to prepare directly calcium, magnesium, manganese and ferrous salts of 2-deoxy-D-gluconic acid.