Publications by authors named "Line Rahal"
Article Synopsis
- The study tackled the difficult task of imaging the trigeminal ganglion (TG), a small and deep-seated structure, by combining advanced imaging techniques to analyze blood flow and respond to orofacial stimuli in rats.
- Functional ultrasound imaging successfully captured strong hemodynamic responses in the TG, linked to various mechanical and chemical stimulations of nociceptive fibers in the face, highlighting the area’s sensitivity despite the limited number of sensory neurons.
- This innovative imaging method not only visualized the vasculature of the TG but also offers new insights for understanding the mechanisms of trigeminal pain, paving the way for future research in treatment options.
Article Synopsis
- Research on spinal cord functionality in chronic pain has been limited in scope, often due to the lack of advanced imaging techniques that can capture detailed spatial and temporal data.
- The study utilized functional ultrasound imaging (fUS) to analyze the spinal cord's blood flow responses to different types of sensory fiber stimulation, providing insights into its vascular structures and hemodyanmic properties.
- Findings indicated that spinal cord responses to stimulation are specific to fiber type, localized, and influenced by inflammatory conditions, which could enhance pain responses — stressing the role of NMDA receptors in the C-fiber response.
Article Synopsis
- * The study uses functional ultrasound imaging to explore alterations in brain connectivity associated with sustained inflammatory pain in a rat model, revealing significant disruptions in the somatomotor network.
- * Findings show that dynamic functional connectivity can reveal different brain states, with arthritic rats spending more time in states of asynchrony between sensory cortex fluctuations and overall network activity, potentially linking these changes to pain behavior.
Medical ultrasound is a widely used diagnostic imaging technique for tissues and blood vessels. However, its spatial resolution is limited to a sub-millimeter scale. Ultrasound Localization Microscopy was recently introduced to overcome this limit and relies on subwavelength localization and tracking of microbubbles injected in the blood circulation.
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