Publications by authors named "Line Fich"
Background: Pregnancy is a complex biological process and serious complications can arise when the delicate balance between the maternal and semi-allogeneic fetal immune systems is disrupted or challenged. Gestational diabetes mellitus (GDM), pre-eclampsia, preterm birth, and low birth weight pose serious threats to maternal and fetal health. Identification of early biomarkers through an in-depth understanding of molecular mechanisms is critical for early intervention.
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- The study investigates the presence and duration of SARS-CoV-2 antibodies (IgA and IgG) in the breastmilk and blood serum of mothers infected during pregnancy, focusing on data collected three and six months after childbirth.
- Results show variation in antibody frequency and concentration, with the highest breastmilk IgA found six months postpartum in mothers infected during the third trimester, and detectable serum IgA lasting over 400 days post-infection.
- No correlation was found between serum and breastmilk IgA or IgG, highlighting complexities in how maternal antibodies are transferred and maintained in breastmilk.
Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Although the exact physiological function of GDF15 is not yet fully comprehended, the significant elevation of circulating GDF15 levels during gestation suggests a potential role for this hormone in pregnancy. This is corroborated by genetic association studies in which GDF15 and the GDF15 receptor, GDNF family receptor alpha like (GFRAL) have been linked to morning sickness and hyperemesis gravidarum (HG) in humans.
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