Publications by authors named "Line Espenhain Landgrebe"
Article Synopsis
- The study investigates how high-fat and low-fat meals affect coagulation biomarkers in individuals with morbid obesity, focusing on factors like factor VII activation and thrombin levels post-meal.
- A controlled cross-over study with 20 obese participants showed significant increases in triglycerides and activated factor VII after high-fat meals, but no increase in thrombin formation was observed.
- Results suggest that the lack of thrombin formation despite increased factor VII activation may be due to inhibition from antithrombin, and the diversity of gut bacteria negatively correlated with certain postprandial coagulation changes.
The effects of sampling from a peripheral venous catheter compared to repeated venepunctures on markers of coagulation, inflammation, and endothelial function.
Line Espenhain Landgrebe Louise Schlosser Mose Yaseelan Palarasah Johannes Jakobsen Sidelmann Else-Marie Bladbjerg
Scand J Clin Lab Invest
December 2019
Article Synopsis
- Peripheral venous (PV) catheters are associated with increased markers of coagulation activation and inflammation compared to traditional venepunctures, although the reasons for this increase remain unclear.
- A study involving 10 healthy subjects compared the effects of blood collection from a PV catheter versus venepunctures, measuring various markers of coagulation, inflammation, and endothelial function.
- Results showed significant increases in certain coagulation markers when using a PV catheter, while measures related to endothelial function remained unchanged, suggesting that blood sampling methods impact coagulation differently and warrant further investigation.