Prospectively Assessed Long-Term Outcomes of Patients with E-Cigarette- or Vaping-associated Lung Injury.

E-cigarette- or vaping-associated lung injury (EVALI) was first identified in 2019. The long-term respiratory, cognitive, mood disorder, and vaping behavior outcomes of patients with EVALI remain unknown. To determine the long-term respiratory, cognitive, mood disorder, and vaping behavior outcomes of patients with EVALI.

SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection.

COVID-19 causes severe disease with poor outcomes. We tested the hypothesis that early SARS-CoV-2 viral infection disrupts innate immune responses. These changes may be important for understanding subsequent clinical outcomes.

SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection.

To examine innate immune responses in early SARS-CoV-2 infection that may change clinical outcomes, we compared nasopharyngeal swab data from 20 virus-positive and 20 virus-negative individuals. Multiple innate immune-related and transcripts increased with infection and were strongly associated with increasing viral load. We found widespread discrepancies between transcription and translation.

Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death.

Unlabelled: Acetaminophen (APAP) is the leading cause of acute liver injury in the developed world. Timely administration of N-acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, whereas failure to administer N-Ac within a critical time frame allows disease progression and in the most severe cases may result in liver failure or death. In this situation, liver transplantation may be the only life-saving measure.

Validation of a single-stage submaximal treadmill walking test.

The single-stage treadmill walking test of Ebbeling et al. is commonly used to predict maximal oxygen consumption (.VO(2max)) from a submaximal effort between 50% and 70% of the participant's age-predicted maximum heart rate.