Publications by authors named "Lindsey Uehlein Klebanow"
Separase is a key regulator of the metaphase to anaphase transition with multiple functions. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to promote exocytosis in mid-anaphase. The anaphase promoting complex/cyclosome (APC/C) activates separase by ubiquitinating its inhibitory chaperone, securin, triggering its degradation.
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- Separase is a protease important for chromosome separation during cell division, but it also has non-proteolytic roles in other organisms.
- Researchers created a transgenic line of the roundworm C. elegans that expresses a non-functional version of separase to study its effects on embryo development.
- The results showed that this non-functional separase leads to embryo death and does not help separase mutants, indicating it disrupts normal separase activity by potentially blocking its interaction with substrates.