Publications by authors named "Lindsey S Gaston"
Article Synopsis
- The hypothalamic-pituitary-adrenal (HPA) axis is key in stress responses, with Crh from the hypothalamus triggering cortisol release from the adrenal gland, influencing anxiety behaviors in mice.
- A study showed that deleting Crh in the hypothalamus reduced anxiety in mice, but this effect was not observed in cases of primary adrenal insufficiency or after treatment with dexamethasone.
- Despite different genetic backgrounds and DEX treatments, all mouse groups demonstrated similar anxiety levels, suggesting that changes in Crh expression might not significantly impact anxiety in conditions like adrenal insufficiency or glucocorticoid therapy.
Premature adrenarche in Prader-Willi syndrome is associated with accelerated pre-pubertal growth and advanced bone age.
J Pediatr Endocrinol Metab
February 2023
Objectives: Prader-Willi syndrome (PWS) is characterized by obesity, growth hormone deficiency, hypogonadism, and a high prevalence of premature adrenarche despite reported hypothalamic-pituitary-adrenal axis dysfunction. While idiopathic premature adrenarche is associated with accelerated pre-pubertal growth and advanced bone age, the consequences of elevated adrenal androgens on growth and bone maturation in PWS remain unknown. This study therefore sought to describe age-related changes in dehydroepiandrosterone sulfate (DHEAS) and their effects on growth and bone maturation in PWS.
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