Publications by authors named "Lindsey M Christman"
Retraction of 'Dealcoholized muscadine wine was partially effective in preventing and treating dextran sulfate sodium-induced colitis and restoring gut dysbiosis in mice' by Hao Li , , 2023, , 5994-6011, https://doi.org/10.1039/D3FO00047H.
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- Muscadine wine contains beneficial compounds like anthocyanins and flavonols and this study investigates its effects on colitis in mice and the gut microbiome.
- Male C57BL/6 mice were fed a specific diet with dealcoholized muscadine wine during different phases (prevention, treatment, combined) while colitis was induced with DSS.
- Results showed that dealcoholized muscadine wine reduced inflammation, improved gut health, and enhanced the gut microbiome, particularly in the group that had both prevention and treatment.
Article Synopsis
- This study explored how muscadine grape polyphenols (MGP) and muscadine wine polyphenols (MWP) affect arthritis in mice, showing they can delay its onset and lessen severity.
- MGP and MWP decreased levels of inflammatory markers and improved joint health, reducing bone and cartilage damage in collagen-induced arthritis (CIA) mice.
- MWP was particularly effective in restoring gut microbiome balance, which is linked to inflammation and arthritis progression, suggesting dietary polyphenols could help manage arthritis in humans.
Inflammatory bowel diseases (IBD) are a group of chronic and recurring inflammatory conditions in the colon and intestine. Their etiology is not fully understood but involves the combination of gut dysbiosis, genetics, immune functions, and environmental factors including diet. Polyphenols from plant-based food synergistically interact with gut microbiota to suppress inflammation and alleviate symptoms of IBD.
View Article and Find Full Text PDFDiabetes affects at least 285 million people globally, and this number continues to increase. Clinical complications include impaired glucose metabolism, hyperglycemia, dyslipidemia, atherosclerosis and non-alcoholic fatty liver disease. Evidence has shown that natural phenolics play a protective effect on both the development and management of type 2 diabetes.
View Article and Find Full Text PDFUnlabelled: Peanut skins are a low-value byproduct of the peanut processing industry. Following their removal during the preparation of common peanut products, they are either discarded or used as a minor component of animal feed. Studies have found peanuts skins to be rich in health promoting phenolic compounds and thus have potential as a functional food ingredient.
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