Publications by authors named "Lindsey Brinkley"

Cholera is a diarrhoeal disease caused by . It remains a major public health challenge in the endemic region around the Bay of Bengal. Over decadal time scales, one lineage typically dominates the others and spreads in global pandemic waves.

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  • A study examined factors connected to long-term neurodevelopmental delays in children who underwent heart transplants, using data from over 3,800 pediatric patients.
  • Results showed that those with definitive motor or cognitive delays had higher rates of congenital heart disease, needed ventilator support during transplant, and had a history of stroke before discharge.
  • Patients with neurodevelopmental delays also experienced worse survival outcomes, with significant correlations found between pre-existing stroke conditions and the likelihood of developing these delays post-transplant.
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Hypercyanotic spells are one of the defining clinical features of Tetralogy of Fallot (TOF). Limited data exist on peak Doppler right ventricular outflow tract (RVOT) gradient as a risk factor for the development of hypercyanotic spells, frequency of prophylactic use of propranolol based on peak RVOT gradient, and its impact on preventing the occurrence of hypercyanotic spells. We aimed to quantify peak RVOT gradients as measured on transthoracic echocardiography in infants with unrepaired TOF and assess for correlation with clinical symptoms of hypercyanotic spells.

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  • Nitric oxide (NO) is a natural gas produced in the body that helps relax smooth muscles and has several protective functions, including improving blood flow and reducing clot formation.
  • Inhaled nitric oxide has been used since the 1990s as a treatment for respiratory issues, with FDA approval for use in neonates with hypoxic respiratory failure, and off-label for other conditions like COVID-19.
  • The article aims to review the biological actions and therapeutic applications of NO, as well as recent findings on its use in cardiopulmonary procedures and potential future uses.
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A Vibrio cholerae O1 outbreak emerged in Haiti in October 2022 after years of cholera absence. In samples from a 2021 serosurvey, we found lower circulating antibodies against V. cholerae lipopolysaccharide in children <5 years of age and no vibriocidal antibodies, suggesting high susceptibility to cholera, especially among young children.

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Despite an increasingly detailed picture of the molecular mechanisms of phage-bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. Here we report a year-long, nation-wide study of diarrheal disease patients in Bangladesh. Among cholera patients, we quantified (prey) and its virulent phages (predators) using metagenomics and quantitative PCR, while accounting for antibiotic exposure using quantitative mass spectrometry.

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After three years with no confirmed cholera cases in Haiti, an outbreak of O1 emerged in October 2022. Levels of pre-existing antibodies provide an estimate of prior immunologic exposure, reveal potentially relevant immune responses, and set a baseline for future serosurveillance. We analyzed dried blood spots collected in 2021 from a population-weighted representative cross-sectional serosurvey in two communes in the Ouest Department of Haiti.

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The antibiotic formulary is threatened by high rates of antimicrobial resistance (AMR) among enteropathogens. Enteric bacteria are exposed to anaerobic conditions within the gastrointestinal tract, yet little is known about how oxygen exposure influences AMR. The facultative anaerobe was chosen as a model to address this knowledge gap.

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