Sepsis Education and Successful Implementation of a Sepsis Recognition and Management Workflow in an Inpatient Pediatric Hematologic Oncologic Unit.

Sepsis is a leading cause of morbidity, mortality, and healthcare utilization for children worldwide. Forty-nine percent of pediatric sepsis patients have an underlying condition rendering them more susceptible to infection. One in six severe sepsis patients has an underlying neoplastic disease and has a 30% higher risk of death compared to other severe sepsis patients.

Complex patterns of protease inhibitor resistance among antiretroviral treatment-experienced HIV-2 patients from Senegal: implications for second-line therapy.

Protease inhibitor (PI)-based antiretroviral therapy (ART) can effectively suppress HIV-2 plasma load and increase CD4 counts; however, not all PIs are equally active against HIV-2, and few data exist to support second-line therapy decisions. To identify therapeutic options for HIV-2 patients failing ART, we evaluated the frequency of PI resistance-associated amino acid changes in HIV-2 sequences from a cohort of 43 Senegalese individuals receiving unboosted indinavir (n = 18 subjects)-, lopinavir/ritonavir (n = 4)-, or indinavir and then lopinavir/ritonavir (n = 21)-containing ART. Common protease substitutions included V10I, V47A, I54M, V71I, I82F, I84V, L90M, and L99F, and most patients harbored viruses containing multiple changes.