Publications by authors named "Lindsey A Bordone"
Article Synopsis
- - Central centrifugal cicatricial alopecia (CCCA) primarily affects Black women and is characterized by scarring that leads to hair loss; conventional treatments focus on inflammation rather than the underlying fibrotic issues.
- - A study was conducted to assess the effects of low-dose oral metformin, an antidiabetic drug with antifibrotic properties, on clinical symptoms and gene expression in CCCA patients unresponsive to standard treatments.
- - Results from 12 participants showed that after at least 6 months of metformin treatment, many experienced symptom improvement and some showed hair regrowth, with gene analysis indicating beneficial changes in pathways related to skin and hair development.
Opportunities to improve the clinical management of skin disease are being created by advances in genomic medicine. Large-scale sequencing increasingly challenges notions about single-gene disorders. It is now apparent that monogenic etiologies make appreciable contributions to the population burden of disease and that they are underrecognized in clinical practice.
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- CD1a, located on skin Langerhans cells, presents lipid antigens, and this study investigates its role in recognizing microbial lipids from skin bacteria.
- Researchers found that T cells respond to the bacterial lipid phosphatidylglycerol (PG) and its modified form, lysylPG, especially abundant in Staphylococcus aureus.
- The results suggest that in patients with atopic dermatitis, there's an increase in T cells that respond to PG-related lipids, indicating a potential link between these lipids and the development of atopic dermatitis.
The primary forms of cicatricial (scarring) alopecia (PCA) are a group of inflammatory, irreversible hair loss disorders characterized by immune cell infiltrates targeting hair follicles (HFs). Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and centrifugal cicatricial alopecia (CCCA) are among the main subtypes of PCAs. The pathogenesis of the different types of PCAs are poorly understood, and current treatment regimens yield inconsistent and unsatisfactory results.
View Article and Find Full Text PDFLichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are scarring alopecias that cause significant distress and psychological morbidity. Limited studies have been performed examining the epidemiology of FFA and LPP. We performed a retrospective case cohort analysis by querying for patients with the ICD 10 code L66.
View Article and Find Full Text PDFBackground: Search algorithms used to identify patients with alopecia areata (AA) need to be validated prior to use in large databases.
Objectives: The aim of the study is to assess whether patients with an International Statistical Classification of Diseases and Related Health Problems (ICD) 9 or 10 code for AA have a true diagnosis of AA.
Materials And Methods: A multicenter retrospective review was performed at Columbia University Irving Medical Center, Brigham and Women's Hospital, and Massachusetts General Hospital to determine whether patients with an ICD 9 codes (704.
Lichen planopilaris (LPP) is an inflammatory cicatricial alopecia for which many different therapies are attempted with varying success. The Janus kinase (JAK) inhibitor, tofacitinib, has been shown to be effective in treating the noncicatricial alopecia, alopecia areata. As in alopecia areata, upregulation of interferon and JAK signaling may play a role in LPP.
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