Publications by authors named "Lindsay Thornton"

Hepatocellular carcinoma, historically, has had a poor prognosis with very few systemic options. Furthermore, most patients at diagnosis are not surgical candidates. Therefore, locoregional therapy (LRT) has been widely used, with strong data supporting its use.

View Article and Find Full Text PDF

Introduction: Ultrasound-guided vascular access is an increasingly popular technique due to its reduced complication and higher success rates. Commercially bought training phantoms allow providers to develop tactile skills in a low-risk setting, but are also expensive and poorly accessible. This study analyzes the efficacy of homemade, low-cost, gelatin-based central line vascular models to teach vascular anatomy and intravascular access techniques in training physicians.

View Article and Find Full Text PDF
Article Synopsis
  • Recent studies on transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) using Yttrium-90 (Y-90) microspheres emphasize the importance of dosimetry from bremsstrahlung SPECT/CT, but often overlook volumetric metrics crucial in radiation oncology.* -
  • Researchers investigated 51 TARE treatments and found that three-dimensional (3D) isodose coverage of the gross tumor volume (GTV) is critical for treatment success, using advanced dosimetry techniques to evaluate Y-90 delivery.* -
  • Results showed that patients with better dosing to the GTV had significantly longer median survival (22.5 months for responders vs. 7
View Article and Find Full Text PDF

Yttrium-90 (Y-90) trans-arterial radioembolization (TARE) is used in the management of unresectable hepatocellular carcinoma (HCC). During the last 5 years, dosimetry software has been developed to allow for a more rigorous approach of dose prescription in Y-90 TARE. We present here a case study of a 77-year-old woman diagnosed with HCC, who underwent a Y-90 TARE as a bridge procedure to liver resection.

View Article and Find Full Text PDF

Purpose: To retrospectively analyze adverse events (AE) in patients with hepatocellular carcinoma (HCC) treated with yttrium-90 radioembolization in the setting of angiographically apparent arterioportal shunts (APSs).

Materials And Methods: Thirty-two patients with HCC underwent radioembolization with APSs from January 2011 to September 2016, totaling 34 administrations using resin (6) and glass (28) microspheres. APSs were graded angiographically as segmental (9), ipsilobar (15), contralobar (7), or main portal (2), according to portal perfusion.

View Article and Find Full Text PDF

Aim: To retrospectively compare the initial response, local recurrence, and complication rates of radiofrequency ablation (RFA) vs microwave ablation (MWA) when combined with neoadjuvant bland transarterial embolization (TAE) or drug-eluting microsphere chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC).

Methods: A total of 35 subjects with Barcelona Clinic Liver Cancer (BCLC) very early and early-stage HCC (range: 1.2-4.

View Article and Find Full Text PDF

Background: To apply quantitative whole-brain T1 -rho (T1ρ ) and T2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS).

Methods: Twenty-three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age-matched healthy controls were imaged at 3 Tesla. An axial T1ρ -weighted three-dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used.

View Article and Find Full Text PDF