Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats.

It has been shown that the renin-angiotensin system (RAS) plays key roles in the development of fibrosis in numerous organs, including the liver. Other studies have suggested that the RAS also may play roles in diseases of chronic inflammation. However, whether the RAS also can mediate acute inflammation in liver is unclear.

Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice.

Background & Aims: Oxidative stress contributes to early alcohol-induced liver injury, and superoxide (O(2)*-) production from NADPH oxidase plays a key role. However, the production of the free radical nitric oxide (NO*) by inducible nitric oxide synthase (iNOS) could also be involved.

Methods: To test this hypothesis, iNOS knockout (B6.