Publications by authors named "Lindsay M Scheetz"
Article Synopsis
- Cancer stem cells (CSCs) play a significant role in tumor growth, spread, and recurrence, but effective targeting methods remain unclear.
- Researchers have found that aldehyde dehydrogenase (ALDH) is a key marker for isolating CSCs and have developed a vaccination approach targeting ALDH.
- The study shows that using synthetic high-density lipoprotein nanodiscs for vaccination can enhance immune responses against ALDH CSCs, and when combined with anti-PD-L1 therapy, it leads to strong antitumor effects and longer survival in mouse models, opening new possibilities for cancer immunotherapy.
Colon carcinomas comprise over two-thirds of all colorectal cancers with an overall 5-year survival rate of 64%, which rapidly decreases to 14% when the cancer becomes metastatic. Depending on the stage of colon carcinoma at diagnosis, patients can undergo surgery to attempt complete tumor resection or move directly to chemotherapy with one or a combination of drugs. As with most cancers, colon carcinomas do not always respond to chemotherapies, so targeted therapies and immunotherapies have been developed to aid chemotherapy.
View Article and Find Full Text PDFNanoplatforms for biomolecule delivery to the lymph nodes have attracted considerable interest as vectors for immunotherapy. Core-shell iron oxide nanoparticles are particularly appealing because of their potential as theranostic magnetic resonance imaging (MRI)-trackable vehicles for biomolecule delivery. The key challenge for utilizing iron oxide nanoparticles in this capacity is control of their coating shells to produce particles with predictable size.
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