Publications by authors named "Lindsay B Volk"
Article Synopsis
- * The mechanisms by which arsenic causes cancer are intricate and not fully understood, involving its metabolism and its targeting of multiple cellular pathways.
- * Future research aimed at improving models and examining human tumors related to arsenic exposure is essential to deepen the understanding of how arsenic induces cancer.
Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic.
Toxicol Appl Pharmacol
January 2022
Arsenic is a naturally occurring element present in food, soil and water and human exposure is associated with increased cancer risk. Arsenic inhibits DNA repair at low, non-cytotoxic concentrations and amplifies the mutagenic and carcinogenic impact of other DNA-damaging agents, such as ultraviolet radiation (UVR). Arsenic exposure leads to oxidation of zinc coordinating cysteine residues, zinc loss and decreased activity of the DNA repair protein poly(ADP)ribose polymerase (PARP)-1.
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