Publications by authors named "Lindsay A Steele"
Article Synopsis
- Bioengineered allogeneic cellularised constructs (BACC) have been shown to enhance healing in burn wounds and may influence macrophage behavior towards a more reparative state.
- The study focused on how BACC affects M2b macrophages, which are relevant in the context of burn wounds, and found that BACC can boost healing-related genes while reducing inflammation, even in the presence of infection-related stimuli.
- Despite not preventing endotoxin tolerance, the BACC successfully promoted a reparative macrophage phenotype, indicating their potential therapeutic role in treating dysregulated macrophage responses in burn injuries.
The mechanisms behind the pro-healing effects of multicellular, bioengineered allogeneic cellularized constructs (BACC) are not known. Macrophages are key regulators of every phase of the wound healing process and the primary cells that mediate the response to biomaterials. It is hypothesized that cells within the BACC modulate macrophage behavior, which may contribute to the mechanism by which BACC promotes healing.
View Article and Find Full Text PDFBiomaterial-assisted macrophage cell therapy for regenerative medicine.
Adv Drug Deliv Rev
August 2023
Although most tissue types are capable of some form of self-repair and regeneration, injuries that are larger than a critical threshold or those occurring in the setting of certain diseases can lead to impaired healing and ultimately loss of structure and function. The immune system plays an important role in tissue repair and must be considered in the design of therapies in regenerative medicine. In particular, macrophage cell therapy has emerged as a promising strategy that leverages the reparative roles of these cells.
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- Citizen science allows non-scientists to contribute to research, particularly in addressing issues relevant to their communities, typically designed by experienced scientists.
- Challenges arise when citizens try to design their own research due to limited training and access to necessary tools, which can lead to overlooked community experiences in health research.
- This approach engages participants from Grade 5 to adults in studying diet and disease using the genetics of Drosophila, empowering them to lead research projects and incorporate community relevance into the findings.
Cyclic strain generated at the cell-material interface is critical for the engraftment of biomaterials. Mechanosensitive immune cells, macrophages regulate the host-material interaction immediately after implantation by priming the environment and remodeling ongoing regenerative processes. This study investigated the ability of mechanically active scaffolds to modulate macrophage function and .
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