Publications by authors named "Lindsay A Catlin"
Applied metagenomics is a powerful emerging capability enabling the untargeted detection of pathogens, and its application in clinical diagnostics promises to alleviate the limitations of current targeted assays. While metagenomics offers a hypothesis-free approach to identify any pathogen, including unculturable and potentially novel pathogens, its application in clinical diagnostics has so far been limited by workflow-specific requirements, computational constraints, and lengthy expert review requirements. To address these challenges, we developed UltraSEQ, a first-of-its-kind accurate and scalable metagenomic bioinformatic tool for potential clinical diagnostics and biosurveillance utility.
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- The OCWMN initially focused on tracking COVID-19 using quantitative qPCR but expanded to include genomic sequencing for detecting variants as the pandemic progressed.
- Recent studies tested various genomic methods for wastewater monitoring to effectively detect and analyze reportable and novel pathogens, including leveraging advanced sequencing technology for better variant detection.