Antenatal thiopurine exposure in women with IBD is associated with intrahepatic cholestasis of pregnancy.

Background: Pregnant women with inflammatory bowel disease (IBD) continue thiopurines to maintain remission. Other studies have reported intrahepatic cholestasis of pregnancy (ICP) in IBD pregnancies exposed to thiopurines. We aimed to investigate whether thiopurines are associated with an increased risk of ICP.

Is sleep deficit associated with infertility and recurrent pregnancy losses? Results from a prospective cohort study.

Introduction: Biological rhythms, the innate cycle of changes in the body's physiological functions, are circadian if they have a 24-hour period. It is known that sleep is a key feature of human circadian rhythm but the relation between sleep and female fertility is largely unknown. This paucity of research is surprising given that circadian rhythms are paramount to human physiology and sleep is related to major female reproductive events.

The increasing incidence of foetal echogenic congenital lung malformations: an observational study.

Objectives: The aim of this study was to investigate the incidence of congenital lung malformations over the past 19 years. Congenital lung malformations (CLM) are a heterogeneous group of lung abnormalities. The antenatal diagnosis is important for foetal and neonatal management but there have been no studies examining whether the reported incidence of this abnormality is constant.

Influence of shift work on early reproductive outcomes: a systematic review and meta-analysis.

Objective: To determine whether an association exists between shift work and early reproductive outcomes.

Data Sources: MEDLINE, Embase, and Web of Science were searched. Additional sources included Google Scholar, the Cochrane Library, online publications of national colleges, the ClinicalTrials.

Are skin scar characteristics associated with the degree of pelvic adhesions at laparoscopy?

Objective: To investigate whether individual or a combination of abdominal surgical scar characteristics can predict the severity and extent of intra-abdominal adhesions.

Design: A prospective cohort study.

Setting: A tertiary referral center in the United Kingdom.