Effects of verapamil on pulmonary haemodynamics during hypoxaemia, at rest, and during exercise in patients with chronic obstructive pulmonary disease.

The haemodynamic effects of intravenous verapamil at rest, during hypoxaemia, and during progressive exercise were evaluated in 10 patients with chronic obstructive lung disease. Verapamil produced significant decreases in the peak heart rate and systemic blood pressure during exercise but exercise capacity and pulmonary gas exchange at exhaustion were unaffected. There were no significant changes in pulmonary artery pressure or total pulmonary vascular resistance during exercise or during the breathing of either air or a hypoxic gas mixture at rest.

Prevention of suctioning-related arterial oxygen desaturation. Comparison of off-ventilator and on-ventilator suctioning.

The purpose of this study was to determine the frequency and severity of arterial oxygen desaturation during and after endotracheal suctioning in a group of ventilator-dependent patients with acute respiratory failure (the majority of whom had underlying obstructive lung disease) and to evaluate the efficacy of several maneuvers designed to minimize desaturation. The adaptor method presented obviates both removal from and reconnection to the ventilator during suctioning, as well as the need to alter ventilator settings. It is concluded that on-ventilator adaptor suctioning is a simple and effective measure for minimizing suctioning-related arterial oxygen desaturation.

A comparative study of Danish (Statens Seruminstitut), Glaxo and Behringwerke vaccines--revaccination of schoolchildren.

Three BCG vaccines were studied for their capacity to evoke tuberculin reactivity and local reactions at revaccination. The vaccines were produced by Statens Seruminstitut in Denmark (vaccine based on the Danish strain 1331), by the Glaxo Laboratories in England (vaccine based on the British strain 1077) and by the Behringwerke in the Federal Republic of Germany (vaccine based on the Danish strain 1331). The study comprised three independent trials (in Gothenburg, Umeå-Skellefteå and Stockholm) in children aged 14-15 years who had been vaccinated with BCG at birth.

Practical considerations in the positioning of EEG electrodes.

Although the 10-20 system of the International Federation was originally proposed as a basis for discussion, there has been little published comment on its strengths and weaknesses or suggestions for its improvement. There are inherent ambiguities in the system, which cannot be applied strictly in accordance with the published specification unless the 4 measurements between the right and left preauricular points and the nasion and the inion are all equal. A study of the cranial measurements of 20 normal adults showed that this criterion was fulfilled to within a margin of 10% in less than half.

Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus, and Actinodendron plumosum.

Eight different polypeptide toxins from sea anemones of four different origins (Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus, and Actinodendron plumosum) have been studied. Three of these toxins are new; the purification procedure for the five other ones has been improved. Sea anemone toxins were assayed (i) for their toxicity to crabs and mice, (ii) for their affinity for the specific sea anemone toxin receptor situated on the Na+ channels of rat brain synaptosomes, and (iii) for their capacity to increase, in synergy with veratridine, the rate of 22Na+ entry into neuroblastoma cells via the Na+ channel.

[Effect of treatment technologies on the nitrate and nitrite content of milk].

The nitrate contents of some evaporated milks or dry skim milks are sometimes abnormally high. Industrial thermal processings increase the amount of nitrates like. After flash pasteurization the level is two fold higher, after pasteurization and sterilization, the level is four hold higher.

[Computer-aided reading of ECG (author's transl)].

Computer-aided reading of 12-lead scalar ECGs was performed in 1800 cardiovascular patients with a tracing-and processing-system of IBM, Periphere Computer Systeme and Schwarzer using the Bonner analysis program. After analog-to-digital conversion and storage on a floppy disk the ECG data were transferred by telefone during night because of lower rates to the IBM computer at Munich. In the same way the prints were received from there.

[Significance of pulmonary artery diastolic pressure after myocardial infarction for physical training (author's transl)].

Functional disorders of the left ventricle after myocardial infarction at rest and with exercise can be evaluated with right heart floating catheter by measuring pulmonary artery diastolic pressure. 45% of 200 patients with myocardial infarctions did not tolerate bicycle exercise test with a work load of 50 Watt during 6 minutes. A routine digitalisation of these patients without strict indication did not improve the results.

[Cow's milk alkaline phospharase. II. Subunit structure, metalloproteic nature and kinetic parameters (author's transl)].

Alkaline phosphatase (EC 3.1.3.

Dephosphorylation of bovine casein by milk alkaline phosphatase.

The pH of optimum activity of alkaline phosphatase from cow's milk depended on the substrate, being 10-1 for rho-nitrophenylphosphate, 8-6 for phosphoserine, 8-0 for phosvitin and 6-8 for casein. Individual casein components were dephosphorylated more rapidly than mixtures of alphas- and beta-caseins or of alphas-, beta-and kappa-caseins and micellar casein. Mixtures of 2 components involving kappa-casein were more readily dephosphorylated than alphas- and beta-casein mixtures.

Mitochondrial and cytoplasmic ribosomes and their activity in blood and culture form Trypanosoma brucei.

Ribosomes of Trypanosoma brucei, a parasitic, flagellated protozoan (order Kinetoplastida), were identified on sucrose density gradients by their radioactively labeled nascent peptides. Ultraviolet absorption revealed only cytoplasmic ribosomes which served as internal sedimentation markers. Synthesis on cytoplasmic ribosomes was completely inhibited by cycloheximide.

Bone induction in implants of decalcified bone and dentine.

The fate of decalcified bone and dentine implanted in muscle and beneath the kidney capsule has been studied in young rats. Quantitatively speaking there was a great deal of variation, but in general the implants became surrounded and invaded by young vascular connective tissue; then tunnels were eroded and cavities enlarged by multi-nucleated giant cells; then the matrix around erosion chambers became recalcified; and finally new bone was induced on the eroded recalcified surfaces. Erosion was much more extensive, and bone was much more readily induced in the intramuscular than in the subcapsular implants.

Cancer patterns in Alameda County, California.

There has been a general increase in the incidence of cancer of most major sites during the period 1960-69; this is true even when allowances are made for shifts in the age composition of the population. Improvements in diagnostic procedures may account for some of these increases but it is doubtful that they are solely responsible for the greater incidence recorded.A few sites stand out as being primarily responsible for the increase in the overall cancer incidence.