Running Gait Complexity During an Overground, Mass-Participation Five-Kilometre Run.

Human locomotion contains innate variability which may provide health insights. Detrended fluctuation analysis (DFA) has been used to quantify the temporal structure of variability for treadmill running, although it has been less commonly applied to uncontrolled overground running. This study aimed to determine how running gait complexity changes in response to gradient and elapsed exercise duration during uncontrolled overground running.

Runners' responses to a biofeedback intervention aimed to reduce tibial acceleration differ within and between individuals.

An increment in peak tibial acceleration (PTA) may be related to an increased risk of running-rated injury. Many authors believe that reducing PTA through improved shock-absorption could, therefore, help prevent injury. The aim of the current study was, therefore, to investigate the individual responses of participants to a biofeedback intervention aimed at reducing PTA.

A Single-Sensor Approach to Quantify Gait in Patients with Hereditary Spastic Paraplegia.

Hereditary spastic paraplegia (HSP) is characterised by progressive lower-limb spasticity and weakness resulting in ambulation difficulties. During clinical practice, walking is observed and/or assessed by timed 10-metre walk tests; time, feasibility, and methodological reliability are barriers to detailed characterisation of patients' walking abilities when instrumenting this test. Wearable sensors have the potential to overcome such drawbacks once a validated approach is available for patients with HSP.

A Double-Blind, Randomized, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease.

Background: Rescue of mitochondrial function is a promising neuroprotective strategy for Parkinson's disease (PD). Ursodeoxycholic acid (UDCA) has shown considerable promise as a mitochondrial rescue agent across a range of preclinical in vitro and in vivo models of PD.

Objectives: To investigate the safety and tolerability of high-dose UDCA in PD and determine midbrain target engagement.

Technical validation of real-world monitoring of gait: a multicentric observational study.

Introduction: Existing mobility endpoints based on functional performance, physical assessments and patient self-reporting are often affected by lack of sensitivity, limiting their utility in clinical practice. Wearable devices including inertial measurement units (IMUs) can overcome these limitations by quantifying digital mobility outcomes (DMOs) both during supervised structured assessments and in real-world conditions. The validity of IMU-based methods in the real-world, however, is still limited in patient populations.

The use of biofeedback for gait retraining: A mapping review.

Background: Biofeedback seems to be a promising tool to improve gait outcomes for both healthy individuals and patient groups. However, due to differences in study designs and outcome measurements, it remains uncertain how different forms of feedback affect gait outcomes. Therefore, the aim of this study is to review primary biomechanical literature which has used biofeedback to alter gait-related outcomes in human participants.

Real-time feedback to improve gait in children with cerebral palsy.

Real-time feedback may be useful for enhancing information gained from clinical gait analysis of children with cerebral palsy (CP). It may also be effective in functional gait training, however, it is not known if children with CP can adapt gait in response to real-time feedback of kinematic parameters. Sixteen children with cerebral palsy (age 6-16; GMFCS I-III), walking with a flexed-knee gait pattern, walked on an instrumented treadmill with virtual reality in three conditions: regular walking without feedback (NF), feedback on hip angle (FH) and feedback on knee angle (FK).

Non-primary breast malignancies: a single institution's experience of a diagnostic challenge with important therapeutic consequences-a retrospective study.

Background: Breast cancer is a common malignancy, but metastases to the breast of extramammary malignancies are very rare. Treatment and prognosis are different. The aim of the study is to report the incidence of lymphomas and metastases to the breast of extramammary malignancies in our 30-year archive.

Biomechanical organization of gait initiation depends on the timing of affective processing.

Gait initiation (GI) from a quiet bipedal posture has been shown to be influenced by the emotional state of the actor. The literature suggests that the biomechanical organization of forward GI is facilitated when pleasant pictures are shown, as compared to unpleasant pictures. However, there are inconsistencies in the literature, which could be due to the neural dynamics of affective processing.