Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study.

Purpose: To evaluate the role of corneal hysteresis (CH) as a risk factor for the rate of visual field progression in a cohort of patients with glaucoma followed prospectively over time.

Design: Prospective observational cohort study.

Participants: The study group included 114 eyes of 68 patients with glaucoma followed for an average of 4.

The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells.

Purpose: To investigate the relationship between cup-to-disc ratio (CDR) and estimates of retinal ganglion cell (RGC) number.

Methods: This cross-sectional study included 156 healthy eyes, 53 glaucoma suspects, and 127 eyes with glaucoma. All eyes had standard automated perimetry (SAP), Cirrus SD-OCT, and stereoscopic optic disc photography within 6 months.

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.

Purpose: To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.

Methods: The study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session.

Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence.

Purpose: To evaluate the reproducibility of measurements of area of β-zone parapapillary atrophy (β-PPA) using blue laser fundus autofluorescence (FAF) and confocal scanning laser ophthalmoscopy reflectance (CSLO) measurements and to assess agreement between the two imaging modalities.

Methods: Sixty-five eyes of 45 patients (mean age, 68.2 ± 11.

The rate of structural change: the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study.

Purpose: To compare rates of topographic change in ocular hypertensive eyes that develop primary open-angle glaucoma (POAG) compared to eyes that do not, and to identify factors that influence the rate of change.

Design: Longitudinal, randomized clinical trial.

Methods: Four hundred forty-one participants (832 eyes) in the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study were included.

Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma.

Importance: It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the patient with slowly progressing damage. However, to our knowledge, this hypothesis has not been investigated in the literature.

Objective: To evaluate the association between binocular rates of visual field change and VRQOL in patients with glaucoma.

Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma.

Purpose: To estimate retinal ganglion cell (RGC) losses associated with the earliest development of visual field defects in glaucoma.

Design: Observational cohort study.

Participants: The study group included 53 eyes of 53 patients with suspected glaucoma who were followed as part of the Diagnostic Innovations in Glaucoma (DIGS) study.

A combined index of structure and function for staging glaucomatous damage.

Objectives: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage.

Methods: Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects. All the eyes were tested with standard automated perimetry and spectral domain optical coherence tomography within 6 months.

The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change.

Purpose: To evaluate the relationship between change in estimated retinal ganglion cell (RGC) counts and change in measures of functional and structural damage in glaucoma, from cross-sectional data.

Methods: The study included 397 eyes of 397 patients with glaucoma, suspects, and healthy individuals. All eyes underwent testing with standard automated perimetry (SAP) and spectral-domain optical coherence tomography (SD-OCT).

Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography.

Purpose: To evaluate the diagnostic accuracy of spectral domain optical coherence tomography (SD-OCT) for detection of preperimetric glaucoma and compare it with the performance of confocal scanning laser ophthalmoscopy (CSLO).

Design: Cohort study.

Participants: A cohort of 134 eyes of 88 glaucoma suspects based on the appearance of the optic disc.

Estimating the rate of retinal ganglion cell loss in glaucoma.

Purpose: To present and evaluate a new method of estimating rates of retinal ganglion cell (RGC) loss in glaucoma by combining structural and functional measurements.

Design: Observational cohort study.

Methods: The study included 213 eyes of 213 glaucoma patients followed up for an average of 4.

A combined index of structure and function for staging glaucomatous damage.

Objectives: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage.

Methods: Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects.All the eyes were tested with standard automated perimetry and spectral domain optical coherence tomography within 6 months.

Progression of patterns (POP): a machine classifier algorithm to identify glaucoma progression in visual fields.

Purpose: We evaluated Progression of Patterns (POP) for its ability to identify progression of glaucomatous visual field (VF) defects.

Methods: POP uses variational Bayesian independent component mixture model (VIM), a machine learning classifier (MLC) developed previously. VIM separated Swedish Interactive Thresholding Algorithm (SITA) VFs from a set of 2,085 normal and glaucomatous eyes into nine axes (VF patterns): seven glaucomatous.

Localized glaucomatous change detection within the proper orthogonal decomposition framework.

Purpose: To detect localized glaucomatous structural changes using proper orthogonal decomposition (POD) framework with false-positive control that minimizes confirmatory follow-ups, and to compare the results to topographic change analysis (TCA).

Methods: We included 167 participants (246 eyes) with ≥4 Heidelberg Retina Tomograph (HRT)-II exams from the Diagnostic Innovations in Glaucoma Study; 36 eyes progressed by stereo-photographs or visual fields. All other patient eyes (n = 210) were non-progressing.

Arterial spin labeling fMRI measurements of decreased blood flow in primary visual cortex correlates with decreased visual function in human glaucoma.

Purpose: Altered metabolic activity has been identified as a potential contributing factor to the neurodegeneration associated with primary open angle glaucoma (POAG). Consequently, we sought to determine whether there is a relationship between the loss of visual function in human glaucoma and resting blood perfusion within primary visual cortex (V1).

Methods: Arterial spin labeling (ASL) functional magnetic resonance imaging (fMRI) was conducted in 10 participants with POAG.

Predicting glaucomatous progression in glaucoma suspect eyes using relevance vector machine classifiers for combined structural and functional measurements.

Purpose: The goal of this study was to determine if glaucomatous progression in suspect eyes can be predicted from baseline confocal scanning laser ophthalmoscope (CSLO) and standard automated perimetry (SAP) measurements analyzed with relevance vector machine (RVM) classifiers.

Methods: Two hundred sixty-four eyes of 193 participants were included. All eyes had normal SAP results at baseline with five or more SAP tests over time.

Incorporating risk factors to improve the assessment of rates of glaucomatous progression.

Purpose: To present and evaluate a new method of integrating risk factors into the analysis of rates of visual field progression in glaucoma.

Methods: The study included 352 eyes of 250 glaucoma patients followed up for an average of 8.1 ± 3.

Combining structural and functional measurements to improve estimates of rates of glaucomatous progression.

Purpose: To evaluate whether a combination of topographic optic disc measurements and visual field data may improve the estimation of rates of structural and functional progression in glaucoma and the prediction of future outcomes in the disease.

Design: Observational cohort study.

Methods: The study included 242 eyes of 179 glaucoma patients followed for an average of 6.

Integrating event- and trend-based analyses to improve detection of glaucomatous visual field progression.

Purpose: To present and evaluate a new method of integrating event- and trend-based analyses of visual field progression in glaucoma.

Design: Observational cohort study.

Participants: The study included 711 eyes of 357 glaucoma patients or suspects followed up for an average of 5.

Association between corneal biomechanical properties and glaucoma severity.

Purpose: To investigate the association between corneal biomechanical parameters using the Ocular Response Analyzer (ORA) and glaucoma severity.

Design: Observational cross-sectional study.

Methods: Two hundred ninety-nine eyes of 191 patients with confirmed or suspect glaucoma were recruited at the University of California, San Diego.

African descent and glaucoma evaluation study: asymmetry of structural measures in normal participants.

Purpose: The purpose of the study is to determine the degree of intereye asymmetry of optic disc topography and retinal nerve fiber layer (RNFL) thickness in healthy individuals of African descent (AD) and European descent (ED).

Design: Observational, clinical study.

Methods: Five hundred nineteen healthy individuals (AD, n=262, mean age=44.

Detection of retinal nerve fibre layer progression: comparison of the fast and extended modes of GDx guided progression analysis.

Purpose: To compare detection of retinal nerve fibre layer changes using GDx guided progression analysis (GPA) fast mode (which assumes fixed variability of a reference population) and extended mode (which measures individual variability), and to determine how they compare with photography and conventional visual field-based methods for identifying glaucoma progression.

Methods: 172 eyes from 117 participants in the Diagnostic Innovations in Glaucoma Study (12 healthy, 108 glaucoma suspects and 52 glaucoma eyes) with ≥ 4 GDx VCC visits and ≥ 3 good quality GDx VCC scans at each visit were included.

Results: Agreement between the GDx GPA fast mode and GDx GPA extended mode was limited.

Structure-function relationships using the Cirrus spectral domain optical coherence tomograph and standard automated perimetry.

Purpose: To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP).

Methods: Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study and from the African Descent and Glaucoma Evaluation Study. All eyes underwent testing with the Cirrus SDOCT and SAP within a 6-month period.

Comparison of visual field severity classification systems for glaucoma.

Purpose: To compare categorical severity classification systems for glaucoma.

Methods: This cross-sectional study included 1,921 eyes (49.5% right eye) from 1,137 participants from the Diagnostic Innovations in Glaucoma Study and African Descent and Glaucoma Evaluation Study.

Structure-function relationship in glaucoma using spectral-domain optical coherence tomography.

Objectives: To determine the structure-function relationship in glaucoma using spectral-domain optical coherence tomography (SDOCT)-derived structural measurements and to evaluate this relationship using a linear model.

Methods: In a cross-sectional study, structure-function relationships were determined for all the participants in the DIGS (Diagnostic Innovations in Glaucoma Study) and the ADAGES (African Descent and Glaucoma Evaluation Study) who had undergone standard automated perimetry (SAP) and SDOCT within 6 months of each other. Strength of relationship was reported as coefficient of determination (R(2)).