Investigation of Functionally Graded Adherents on Failure of Socket Joint of FRP Composite Tubes.

Fiber-reinforced polymer (FRP) matrix materials are quickly being investigated for application in concrete construction repair, reinforcement, and refurbishment. The technology has progressed to the point that its future acceptance is mainly reliant on the availability of established design guidelines based on recognized performance criteria, as well as the cost competitiveness of these technologies in contrast to conventional rehabilitation methods. The goal of this study is to evaluate the different functional grades of adhesives throughout bond length for bonded socket joints of laminated FRP composite pipes.

Investigating the Efficacy of Adhesive Tape for Drilling Carbon Fibre Reinforced Polymers.

In the present research work, an effort has been made to explore the potential of using the adhesive tapes while drilling CFRPs. The input parameters, such as drill bit diameter, point angle, Scotch tape layers, spindle speed, and feed rate have been studied in response to thrust force, torque, circularity, diameter error, surface roughness, and delamination occurring during drilling. It has been found that the increase in point angle increased the delamination, while increase in Scotch tape layers reduced delamination.

A Comparative Analysis of Laser Additive Manufacturing of High Layer Thickness Pure Ti and Inconel 718 Alloy Materials Using Finite Element Method.

Investigation of the selective laser melting (SLM) process, using finite element method, to understand the influences of laser power and scanning speed on the heat flow and melt-pool dimensions is a challenging task. Most of the existing studies are focused on the study of thin layer thickness and comparative study of same materials under different manufacturing conditions. The present work is focused on comparative analysis of thermal cycles and complex melt-pool behavior of a high layer thickness multi-layer laser additive manufacturing (LAM) of pure Titanium (Ti) and Inconel 718.

Elucidating the Role of Interfacial Hydrogen Bonds on Glass Transition Temperature Change in a Poly(Vinyl Alcohol)/SiO Polymer-Nanocomposite by Noncovalent Interaction Characterization and Atomistic Molecular Dynamics Simulations.

A thorough experimental investigation of polymer-glass transition temperature (T ) is performed on poly(vinyl alcohol) (PVA) and fumed silica nanoparticle (SiNP) composite. This is done together with atomistic molecular dynamics simulations of PVA systems in contact with bare and fully hydroxylated silica. Experimentally, PVA-SiNP composites are prepared by simple solution casting from aqueous solutions followed by its characterization using Fourier-transform infrared spectroscopy (FTIR), dynamic mechanical analysis (DMA), and dynamic scanning calorimetry (DSC).

Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy.

Background: Midline gliomas like diffuse intrinsic pontine glioma (DIPG) carry poor prognosis and lack effective treatment options. Studies have implicated amplifications in the phosphatidylinositol 3-kinase (PI3K) signaling pathway in tumorigenesis; compensatory activation of parallel pathways (eg, mitogen-activated protein kinase [MEK]) may underlie the resistance to PI3K inhibition observed in the clinic.

Methods: Three patient-derived cell lines (SU-DIPG-IV, SU-DIPG-XIII, and SF8628) and a mouse-derived brainstem glioma cell line were treated with PI3K (ZSTK474) and MEK (trametinib) inhibitors, alone or in combination.

A Murine Model for Quantitative, Real-Time Evaluation of Convection-Enhanced Delivery (RT-CED) Using an [F]-Positron Emitting, Fluorescent Derivative of Dasatinib.

The blood brain barrier can limit the efficacy of systemically delivered drugs in treating neurological malignancies; therefore, alternate routes of drug administration must be considered. The Abl-kinase inhibitor, dasatinib, is modified to give compound ([F]-) so that F-positron emission tomography (PET) and fluorescent imaging can both be used to observe drug delivery to murine orthotopic glioma. Western blotting, binding studies (IC = 22 ± 5 nmol/L), and cell viability assays (IC = 46 ± 30 nmol/L) confirm nanomolar, effectiveness of [F]-, a dasatinib derivative that is visible by F-PET and fluorescence.

Hyperlensing at NIR frequencies using a hemispherical metallic nanowire lens in a sea-urchin geometry.

Label-free and real time far-field super-resolution imaging (hyperlensing) at the nanoscale is of significant interest where sub-λ imaging remains a constraint because of Abbe's diffraction limit. Though by utilizing anisotropic permittivities, metal-dielectric multilayers have been successful in reconstructing high-frequency components of sub-λ objects, yet they remain cumbersome and expensive to make. Most of the multilayer structures require multiple vacuum deposition cycles and are plagued by stringent requirements on the surface roughness of metallic layers.