A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study.

Objective: To test for a urate gene-by-diuretic interaction on incident gout.

Methods: The Atherosclerosis Risk in Communities Study is a prospective population-based cohort of 15 792 participants recruited from four US communities (1987-1989). Participants with hypertension and available single nucleotide polymorphism (SNP) genotype data were included.

Contribution of higher risk genes and European admixture to Crohn's disease in African Americans.

Background: African Americans (AAs) are an admixed population of West African (WA) and European ancestry (EA). Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution of European admixture and major established risk genes to AA CD.