Evaluation of intrastromal lipid deposits after intacs implantation using in vivo confocal microscopy.

Purpose: To assess the structure and location of intrastromal lipid deposits after implantation of Intacs by using in vivo confocal microscopy.

Methods: Seven eyes of six patients were examined by in vivo confocal microscopy 5 years (n = 6) or 2 months (n = 1) after uncomplicated implantation of Intacs for the correction of mild myopia. Selected images from all corneal layers were qualitatively evaluated for structural changes, with special attention paid to areas surrounding the Intacs implants.

Confocal assessment of the effects of fourth-generation fluoroquinolones on the cornea.

Purpose: To evaluate the toxicity of fourth-generation fluoroquinolone antibiotic solutions on the rabbit corneal epithelium.

Methods: In vivo confocal microscopy was used to assess epithelial structure in 18 rabbits, and tight junction integrity of superficial epithelial cells was evaluated with ZO-1 labeling in 10 rabbits. Eyes were bathed with commercial solutions of moxifloxacin (Vigamox) or gatifloxacin (Zymar) solution for 3 minutes, rinsed with balanced salt solution, and immediately examined.