Publications by authors named "Linda Studer"
Background: The International Collaboration on Cancer Reporting proposes histological tumour type, lymphovascular invasion, tumour grade, perineural invasion, extent, and dimensions of invasion as risk factors for lymph node metastases and tumour progression in completely endoscopically resected pT1 colorectal cancer (CRC).
Objective: The aim of the study was to propose a predictive and reliable score to optimise the clinical management of endoscopically resected pT1 CRC patients.
Methods: This multi-centric, retrospective International Budding Consortium (IBC) study included an international pT1 CRC cohort of 565 patients.
Article Synopsis
- Computer-aided diagnostics in histopathology rely on digitized glass slides, but differences in images from various scanners can negatively affect algorithm performance.
- The study assessed the impact of scanner variability on lymph node segmentation in colorectal cancer using 100 scanned slides, with three segmentation methods evaluated: HCT, HAC, and U-Net.
- Results indicated that fine-tuning models and using domain adversarial learning techniques significantly improved segmentation accuracy across different scanners, with U-Net and HAC achieving the highest performance metrics.
Article Synopsis
- * Traditional pre-trained networks often don't perform well when faced with new domains due to variations in tissue characteristics, while existing domain adaptation methods usually depend on fully labeled datasets.
- * The proposed method, Self-Rule to Multi-Adapt (SRMA), uses self-supervised learning to adapt across domains without needing fully labeled source data, demonstrating improved classification of colorectal tissue types and offering an open-source solution.
Tumour budding in colorectal cancer, defined as single tumour cells or small clusters containing four or fewer tumour cells, is a robust and independent biomarker of aggressive tumour biology. On the basis of published data in the literature, the evidence is certainly in favour of reporting tumour budding in routine practice. One important aspect of implementing tumour budding has been to establish a standardised and evidence-based scoring method, as was recommended by the International Tumour Budding Consensus Conference (ITBCC) in 2016.
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