Malignancies after mitoxantrone for multiple sclerosis: A retrospective cohort study.

Objective: To assess the therapy-related risk of malignancies in mitoxantrone-treated patients with multiple sclerosis.

Methods: This retrospective observational cohort study included all mitoxantrone-treated patients with multiple sclerosis seen at our department between 1994 and 2007. We collected follow-up information on medically confirmed malignancies, life status, and cause of death, as of 2010.